Ultrasound-guided platelet-rich plasma injection for the treatment of recalcitrant rotator cuff disease in wheelchair users with spinal cord injury: A pilot study

Dyson-Hudson, Trevor; Hogaboom, Nathan; Nakamura, Reina; Terry, Alon; Malanga, Gerard A.

doi:10.1080/10790268.2020.1754676

Cited by 9 publications

(17 citation statements)

References 36 publications

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“…During the 24-week follow-up period, the wheelchair user shoulder pain index, pain NRS, and the physical examination scores showed a downward trend. The overall condition of the patient improved and no adverse events were reported ( 125 ). The efficacy of PRP has also been demonstrated in shoulder pain caused by biceps tendinopathy ( 126 ).…”

Section: Application Of Prp In Spine Surgerymentioning

confidence: 99%

Application of platelet-rich plasma in spinal surgery

et al. 2023

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With the aging of the population and changes in lifestyle, the incidence of spine-related diseases is increasing, which has become a major global public health problem; this results in a huge economic burden on the family and society. Spinal diseases and complications can lead to loss of motor, sensory, and autonomic functions. Therefore, it is necessary to identify effective treatment strategies. Currently, the treatment of spine-related diseases includes conservative, surgical, and minimally invasive interventional therapies. However, these treatment methods have several drawbacks such as drug tolerance and dependence, adjacent spondylosis, secondary surgery, infection, nerve injury, dural rupture, nonunion, and pseudoarthrosis. Further, it is more challenging to promote the regeneration of the interstitial disc and restore its biomechanical properties. Therefore, clinicians urgently need to identify methods that can limit disease progression or cure diseases at the etiological level. Platelet-rich plasma (PRP), a platelet-rich form of plasma extracted from venous blood, is a blood-derived product. Alpha granules contain a large number of cytokines, such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor, platelet factor 4 (PF-4), insulin-like growth factor-1 (IGF-1), and transforming growth factor-β (TGF-β). These growth factors allow stem cell proliferation and angiogenesis, promote bone regeneration, improve the local microenvironment, and enhance tissue regeneration capacity and functional recovery. This review describes the application of PRP in the treatment of spine-related diseases and discusses the clinical application of PRP in spinal surgery.

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Section: Application Of Prp In Spine Surgerymentioning

confidence: 99%

Application of platelet-rich plasma in spinal surgery

et al. 2023

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“…Six wheelchair patients (three paraplegia and three tetraplegia) who had chronic shoulder pain due to rotator cuff disease and failed conservative treatment for at least 6 months were treated with ultrasound-guided L-PRP and a stretching and strengthening exercise program was prescribed. They found that L-PRP was safe and provided improvements in shoulder pain outcomes at 24 weeks ( 71 ).…”

Section: Safety Of Prp Application In the Shouldermentioning

confidence: 99%

The role of platelet-rich plasma in shoulder pathologies: a critical review of the literature

Rosso

Morrey²,

Grezda

et al. 2023

EFORT Open Reviews

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Platelet-rich plasma (PRP) is a revolutionary treatment that harnesses the regenerative power of the body's own platelets to promote healing and tissue regeneration. While PRP therapy has emerged as a promising option for augmenting biologic healing in the shoulder, the complexity of shoulder disorders makes it difficult to draw definitive conclusions about the efficacy of PRP across different conditions and stages of disease. Our comprehensive review of twenty-four studies highlights the current state of PRP therapy in shoulder pathologies, revealing a wide variety of number of patients, control groups and results. Despite these challenges, the regenerative potential of PRP therapy is moderate in some conditions, with numerous studies demonstrating the positive effects. In conclusion, the authors of this study recommend the use of PRP therapy for adhesive capsulitis and rotator cuff repair of medium to large tears. However, they do not recommend the use of PRP for subacromial impingement or rotator cuff tears. It is up to the clinician's discretion to decide whether PRP therapy is appropriate for individual cases. However, there is still insufficient evidence to support the inclusion of PRP therapy in treatment protocols for other shoulder disorders. Therefore, further research is needed to fully explore the potential of PRP therapy in the treatment of various shoulder conditions.

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“…29 Few case reports have reported improvement in pain and function that was maintained for few months to a year. 30,31 Dyson-Hudson et al 16 and Hogaboom et al 15 both used ultrasound-guided injections into the shoulder in addition to a stretching and strengthening program. Dyson-Hudson et al 16 filtered PRP from participants' blood and then injected it into the supraspinatus tendon.…”

Section: Regenerative Medicinementioning

confidence: 99%

“…32 Participants of the study reported an improvement in their SP. 16 Hogaboom et al 15 harvested adipose tissue from the participant's abdomen, processed it into microfragmented adipose tissue, and injected the MFAT into the supraspinatus tendon and other individual structures in the shoulder that were degenerated. Adipose tissue is known to have potentially regenerative components and can provide cushioning in the joints.…”

Section: Regenerative Medicinementioning

confidence: 99%