Ultrasound-Guided Minimally Invasive Autopsy of Respiratory Muscles as a Safe and Cost-Effective Technique in COVID-19 Pandemic Era

Nucci, Ricardo Aparecido Baptista; Dolhnikoff, Marisa; Saldiva, Paulo; Jacob‐Filho, Wilson

doi:10.1159/000514222

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Considering the respiratory muscles, and in particular the diaphragm, the application of ultrasound imaging (US) techniques to assess muscular dysfunction, morphological changes and/or responses to rehabilitation, are a valid strategy [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Two main ultrasound approaches to image the diaphragm have been consistently reported in the literature: the mid-axillary intercostal approach at the zone of apposition, and the subcostal approach using the liver or spleen as an acoustic window [28,30] (Figure 2).…”

Section: Ultrasound Imaging Techniquesmentioning

confidence: 99%

The Possible Impact of COVID-19 on Respiratory Muscles Structure and Functions: A Literature Review

et al. 2022

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The impact of SARS-CoV-2 infection on respiratory muscle functions is an important area of recent enquiry. COVID-19 has effects on the respiratory muscles. The diaphragm muscle is perturbed indirectly due to the mechanical-ventilation-induced-disuse, but also by direct mechanisms linked with SARS-CoV-2 viral infection. In this sense, a deeper understanding of the possible links between COVID-19 and alterations in structure and functions of the respiratory muscles may increase the success rate of preventive and supportive strategies. Ultrasound imaging alongside respiratory muscle strength tests and pulmonary function assessment are valid approaches to the screening and monitoring of disease, for mild to severe patients. The aim of the present review is to highlight the current literature regarding the links between COVID-19 and respiratory muscle functions. We examine from the pathophysiological aspects of disease, up to approaches taken to monitor and rehabilitate diseased muscle. We hope this work will add to a greater understanding of the pathophysiology and disease management of respiratory muscle pathology subsequent to SARS-CoV-2 infection.

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Section: Ultrasound Imaging Techniquesmentioning

confidence: 99%

The Possible Impact of COVID-19 on Respiratory Muscles Structure and Functions: A Literature Review

et al. 2022

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“…Thirteen studies (65%) used imaging methods to guide MITS; most of them (10/13; 77%) used ultrasound guidance. Two studies (10%) included only limited sampling of 1 specific type of tissue [ 46 , 47 ], and did not include lungs or other organs key to cause-of-death attribution. In 11 studies (55%), the sampling was mainly limited to the lungs or to the lungs plus liver and/or heart.…”

Section: Resultsmentioning

confidence: 99%

Minimally Invasive Tissue Sampling as an Alternative to Complete Diagnostic Autopsies in the Context of Epidemic Outbreaks and Pandemics: The Example of Coronavirus Disease 2019 (COVID-19)

Bassat

Varo

Hurtado

et al. 2021

Clinical Infectious Diseases

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Background Infectious diseases’ outbreak investigation requires, by definition, conducting a thorough epidemiological assessment while simultaneously obtaining biological samples for an adequate screening of potential responsible pathogens. Complete autopsies remain the gold-standard approach for cause-of-death evaluation and characterization of emerging diseases. However, for highly transmissible infections with a significant associated lethality, such as COVID-19, complete autopsies are seldom performed due to biosafety challenges, especially in low-resource settings. Minimally invasive tissue sampling (MITS) is a validated new approach based on obtaining postmortem samples from key organs and body fluids, a procedure that does not require advanced biosafety measures or a special autopsy room. Methods We aimed to review the use of MITS or similar procedures for outbreak investigation up to 27 March 2021 and their performance for evaluating COVID-19 deaths. Results After a literature review, we analyzed in detail the results of 20 studies conducted at international sites, whereby 216 COVID-19–related deaths were investigated. MITS provided a general and more granular understanding of the pathophysiological changes secondary to the infection and high-quality samples where the extent and degree of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–related damage could be evaluated. Conclusions MITS is a useful addition in the investigation and surveillance of infections occurring in outbreaks or epidemics. Its less invasive nature makes the tool more acceptable and feasible and reduces the risk of procedure-associated contagion, using basic biosafety measures. Standardized approaches protocolizing which samples should be collected—and under which exact biosafety measures—are necessary to facilitate and expand its use globally.

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Ultrasound-Guided Minimally Invasive Autopsy of Respiratory Muscles as a Safe and Cost-Effective Technique in COVID-19 Pandemic Era

Cited by 2 publications

References 14 publications

The Possible Impact of COVID-19 on Respiratory Muscles Structure and Functions: A Literature Review

The Possible Impact of COVID-19 on Respiratory Muscles Structure and Functions: A Literature Review

Minimally Invasive Tissue Sampling as an Alternative to Complete Diagnostic Autopsies in the Context of Epidemic Outbreaks and Pandemics: The Example of Coronavirus Disease 2019 (COVID-19)

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