Ultrasound-guided Microbubble in the Treatment of Cancer: A Mini Narrative Review

Rajendran, Minu Ambika

doi:10.7759/cureus.3256

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…Ultrasound and microbubbles have received a lot of attention to aid in TME penetration and actively promote drug delivery to the tumor [9,[316][317][318]. Microbubble cavitation has been investigated to actively cross the endothelium but the exact mechanical effects on the underlying tumor microenvironment remain largely unexplored [302].…”

Section: Tumor-specific Barriersmentioning

confidence: 99%

Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

Deprez

Lajoinie

Engelen

et al. 2021

Advanced Drug Delivery Reviews

125

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Section: Tumor-specific Barriersmentioning

confidence: 99%

Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

Deprez

Lajoinie

Engelen

et al. 2021

Advanced Drug Delivery Reviews

125

View full text Add to dashboard Cite

“…MBs are gas-filled, echogenic bubbles with a diameter typically comprised between 0.5 and 10 µm commonly used as contrast agents (CAs) in medical imaging and as carriers for targeted drug delivery, recently also gaining attention in the field of cancer diagnosis and treatment [94,95]. They consist of a low solubility complex gas, such as a perfluorocarbon (PFC) gas, surrounded by an external shell generally composed of phospholipids.…”

Section: Microbubbles In Diagnosis and Ctc Detectionmentioning

confidence: 99%

Nano Meets Micro-Translational Nanotechnology in Medicine: Nano-Based Applications for Early Tumor Detection and Therapy

et al. 2020

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Nanomaterials have great potential for the prevention and treatment of cancer. Circulating tumor cells (CTCs) are cancer cells of solid tumor origin entering the peripheral blood after detachment from a primary tumor. The occurrence and circulation of CTCs are accepted as a prerequisite for the formation of metastases, which is the major cause of cancer-associated deaths. Due to their clinical significance CTCs are intensively discussed to be used as liquid biopsy for early diagnosis and prognosis of cancer. However, there are substantial challenges for the clinical use of CTCs based on their extreme rarity and heterogeneous biology. Therefore, methods for effective isolation and detection of CTCs are urgently needed. With the rapid development of nanotechnology and its wide applications in the biomedical field, researchers have designed various nano-sized systems with the capability of CTCs detection, isolation, and CTCs-targeted cancer therapy. In the present review, we summarize the underlying mechanisms of CTC-associated tumor metastasis, and give detailed information about the unique properties of CTCs that can be harnessed for their effective analytical detection and enrichment. Furthermore, we want to give an overview of representative nano-systems for CTC isolation, and highlight recent achievements in microfluidics and lab-on-a-chip technologies. We also emphasize the recent advances in nano-based CTCs-targeted cancer therapy. We conclude by critically discussing recent CTC-based nano-systems with high therapeutic and diagnostic potential as well as their biocompatibility as a practical example of applied nanotechnology.

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“…The sudden expansion in maximum radial of oscillation may lead to forceful rapture due to the increase in inertial forces. This occurrence has been proven to be useful in local drugs release and gene release into microvessel walls and cell membrane [29,30].…”

Section: Maximum Radiusmentioning

confidence: 99%

Nonlinear dynamics of a shell encapsulated microbubble near solid boundary in an ultrasonic field

Ali¹,

Dzaharudin²,

Alias³

2020

JMES

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Microbubbles have the potential to be used for diagnostic imaging and therapeutic delivery. However, the transition from microbubbles currently being used as ultrasound contrast agents to achieve its’ potentials in the biomedical field requires more in depth understanding. Of particular importance is the influence of microbubble encapsulation of a microbubble near a vessel wall on the dynamical behaviour as it stabilizes the bubble. However, many bubble studies do not consider shell encapsulation in their studies. In this work, the dynamics of an encapsulated microbubble near a boundary was studied by numerically solving the governing equations for microbubble oscillation. In order to elucidate the effects of a boundary to the non-linear microbubble oscillation the separation distances between microbubble will be varied along with the acoustic driving. The complex nonlinear vibration response was studied in terms of bifurcation diagrams and the maximum radial expansion. It was found that the increase in distance between the boundary and the encapsulated bubble will increase the oscillation amplitude. When the value of pressure amplitude increased the single bubble is more likely to exhibit the chaotic behaviour and maximum radius also increase as the inter wall-bubble distance is gradually increased. While, with higher driving frequency the maximum radial expansion decreases and suppress the chaotic behaviour.

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Ultrasound-guided Microbubble in the Treatment of Cancer: A Mini Narrative Review

Cited by 10 publications

References 15 publications

Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

Nano Meets Micro-Translational Nanotechnology in Medicine: Nano-Based Applications for Early Tumor Detection and Therapy

Nonlinear dynamics of a shell encapsulated microbubble near solid boundary in an ultrasonic field

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