Ultrasound-Guided Fine-Needle Capillary Biopsy of Thyroid Nodules, Coupled with On-Site Cytologic Review, Improves Results

Ceresini, Graziano; Corcione, Luigi; Morganti, S.; Milli, Bruna; Bertone, Luca; Prampolini, R.; Petrazzoli, S.; Saccani, Martina; Ceda, Gian Paolo; Valenti, Giorgio

doi:10.1089/105072504774193230

Cited by 49 publications

(50 citation statements)

References 26 publications

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“…Thorough physical examination, multiple passes to cover all areas of interest, and ultrasound-guided aspiration may reduce sampling errors. 19,21 Errors caused by misinterpretation of cytologic findings in adequate samples are uncommon. Two major sources of such errors are cystic PCT and FN.…”

Section: -15mentioning

confidence: 99%

Fine-needle aspiration of thyroid nodules: A study of 4703 patients with histologic and clinical correlations

Yang

Schnadig

Logroño

et al. 2007

Cancer

615

522

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Objective Both increased production of reactive oxygen and nitrogen intermediates (RONI) and reduced levels of complement may play a role in the increased apoptosis and reduced clearance of apoptotic cells in systemic lupus erythematosus (SLE). The objective of this study was to evaluate both processes in a parallel, prospective, longitudinal manner. Methods Sixty‐seven SLE patients were evaluated during multiple visits, and 31 healthy control subjects were evaluated once or twice. Clinical and laboratory features of SLE disease activity were determined, and blood was collected for measurement of serum nitrate plus nitrite (NOx) levels and for isolation of peripheral blood mononuclear cells (PBMCs). PBMCs were cultured with a nitric oxide (NO) donor and SLE or control plasma, with or without heat inactivation, cobra venom factor (CVF), or lipopolysaccharide plus interferon‐γ treatment. Cells were analyzed for apoptotic index (AI), cellular subsets, and RONI production. Results The PBMC AI was associated with SLE and was inversely associated with complement levels over time. Changes in the AI with addition of a NO donor was longitudinally associated with serum NOx levels, and stimulation of SLE PBMCs led to parallel increases in RONI production and apoptosis. Addition of SLE plasma resulted in a greater PBMC AI, an effect that was increased with heat inactivation and was corrected with CVF treatment. Conclusion These data suggest that the greater AI observed in SLE PBMCs relates to increased PBMC RONI production and reduced complement levels. The longitudinal nature of these parallel associations within individuals suggests that these processes are dynamic and additive.

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Section: -15mentioning

confidence: 99%

Fine-needle aspiration of thyroid nodules: A study of 4703 patients with histologic and clinical correlations

Yang

Schnadig

Logroño

et al. 2007

Cancer

615

522

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“…and infarction [18]. Trauma-related consequences may be minimised by using a fine-needle biopsy procedure without aspiration (fine-needle capillary technique).…”

Section: Prace Oryginalnementioning

confidence: 99%

“…Trauma-related consequences may be minimised by using a fine-needle biopsy procedure without aspiration (fine-needle capillary technique). In this method, cells are detached by the cutting edge of the needle and are conducted into the lumen by capillary forces [18]. The absence of the vacuum effect of aspiration results in a significant reduction in trauma to the nodule and surrounding thyroid tissues and thus reduces blood contamination and yields higher quality material [18,21].…”

Section: Prace Oryginalnementioning

confidence: 99%

“…In this method, cells are detached by the cutting edge of the needle and are conducted into the lumen by capillary forces [18]. The absence of the vacuum effect of aspiration results in a significant reduction in trauma to the nodule and surrounding thyroid tissues and thus reduces blood contamination and yields higher quality material [18,21]. The capillary technique is therefore recommended, especially for nodules found to be highly vascular on colour Doppler imaging [4,10,11].…”

Section: Prace Oryginalnementioning

confidence: 99%

“…Although 20-27 gauge (G) needles are usually used for biopsy, few studies to date have compared the adequacy of samples obtained with different sized needles [10,[14][15][16][17]. Moreover, onsite evaluation of biopsy samples by a cytopathologist has been reported to increase the success rate of biopsy procedures, reducing the need to repeat the biopsy and decreasing the rate of false negative results [8,18]. By reducing the number of interventions, on-site cytopathological evaluation may also reduce the risk of patient complications [8,19].…”

Section: Introductionmentioning

confidence: 99%

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Biopsje cienkoigłowe guzków tarczycy pod kontrolą USG — porównanie wydajności próbki za pomocą różnych technik pobierania próbek, rozmiarów igieł, z/bez analizy cytologicznej na miejscu

Cerit

Yücel

Göçün

et al. 2015

Endokrynologia Polska

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Introduction: The aim of this study was to compare the diagnostic adequacy of thyroid samples obtained by aspiration or capillary biopsy techniques, with 22 or 27 gauge needles, and with or without onsite cytological analysis (OCA). Material and methods: Four hundred patients with thyroid nodules underwent ultrasound (US)-guided fine-needle biopsies. Patients were divided into eight groups according to needle size (22 vs. 27 gauge), biopsy technique (aspiration vs. capillary), and whether or not OCA was performed. Sample adequacy rates were calculated for each group and subgroups and compared using chi-square tests. Results: When all nodes were evaluated (n = 400), the adequacy rate was significantly greater with the capillary than with the aspiration technique (97% vs. 91.5%, p = 0.032) and when OCA was than was not performed (97% vs. 91.5%, p = 0.032). When only solid nodules were evaluated (n = 205) the adequacy rate was also significantly greater with the capillary than with the aspiration technique (98.9% vs. 89.7%, p = 0.008) and when OCA was than was not performed (97.9% vs. 89.6%, p = 0.014). In contrast, the adequacy rate was similar for 22 and 27 gauge needles (94.2% vs. 93.1%, p = 0.733). Conclusions:Optimal results were obtained with the capillary technique and OCA. The capillary technique and OCA should be the preferred approach in thyroid nodule biopsy, optimising adequacy rates and patient comfort. (Endokrynol Pol 2015; 66 (4): 295-300)

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On‐site adequacy evaluations performed by cytotechnologists

Burlingame

Kessé

Silverman

et al. 2011

Cancer Cytopathology

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BACKGROUND: Practice patterns regarding on‐site assessment of the adequacy of image‐guided fine‐needle aspiration biopsies (FNABs) vary among laboratories, but in many laboratories primary responsibility rests with the cytotechnologists. On‐site evaluation provides feedback on the need for additional passes and facilitates triaging of the specimen for time‐sensitive ancillary studies. Prior studies have suggested that cytotechnologists can assess the initially obtained specimens correctly, but they are few in number and limited by small size. The purpose of this study was to assess the frequency with which our cytotechnologists were able to correctly assess specimens as adequate using a large‐scale database that included a wide range of image‐guided FNABs. METHODS: The frequency that on‐site adequacy assessments of 5241 image‐guided FNABs were correct was determined by correlating the cytotechnologists' assessments of adequacy with the final cytologic interpretation. An adequacy assessment was considered correct if the FNAB was ultimately reported as satisfactory and unequivocally benign or malignant. An adequate reading on a case that was ultimately reported as unsatisfactory, atypical, or suspicious was deemed “incorrect.” The effect of imaging modality was also analyzed. RESULTS: Of 5241 FNABs, 2784 (53%) were interpreted as adequate on site. Of these, 2637 (95%) were correctly considered adequate. Of the common biopsy sites sampled, the adequacy assessments for liver FNABs demonstrated the highest frequency for being correctly considered adequate (97%) and those for kidney FNABs showed the lowest (90%). Imaging modality had no effect on accuracy. CONCLUSIONS: Cytotechnologists are almost always correct when assessing initial FNAB samples as adequate. Cancer (Cancer Cytopathol) 2012;. © 2011 American Cancer Society.

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Ultrasound-Guided Fine-Needle Capillary Biopsy of Thyroid Nodules, Coupled with On-Site Cytologic Review, Improves Results

Cited by 49 publications

References 26 publications

Fine-needle aspiration of thyroid nodules: A study of 4703 patients with histologic and clinical correlations

Fine-needle aspiration of thyroid nodules: A study of 4703 patients with histologic and clinical correlations

Biopsje cienkoigłowe guzków tarczycy pod kontrolą USG — porównanie wydajności próbki za pomocą różnych technik pobierania próbek, rozmiarów igieł, z/bez analizy cytologicznej na miejscu

On‐site adequacy evaluations performed by cytotechnologists

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