Ultrasound-Guided Diffuse Optical Tomography for Predicting and Monitoring Neoadjuvant Chemotherapy of Breast Cancers

Abstract

In this manuscript, we review the current progress of utilizing ultrasound-guided diffuse optical tomography (US-guided DOT) for predicting and monitoring neoadjuvant chemotherapy (NAC) outcomes of breast cancer patients. We also report the recent advance on optical tomography systems toward portable and robust clinical use at multiple clinical sites. The first patient who has been closely monitored before NAC, at day 2, day 8, end of first three cycles of NAC, and before surgery is given as an example to demonstrate the potential of US-guided DOT technique.

Chromophore decomposition in multispectral time-resolved diffuse optical tomography

“…Thus compared to the results obtained with the standard code, the prior spatial information of the inclusion improves significantly the accuracy of the quantification and compensates the quantification degradation due to depth. These observations are in agreement with results reported in recent works [29][30][31], where the use of other techniques (such as ultrasound imaging) to detect the position and shape of the inclusions (i.e. the a priori information) have been demonstrated useful to improve tomographic reconstructions.…”

“…We have demonstrated in [19] that this improves significantly the accuracy of the retrieved absorption coefficient. The assumption of a known geometry is justified when dealing with multimodal imaging techniques like for example the combination of diffuse optical imaging with ultrasound imaging [29][30][31].…”

Diffuse optical tomography reconstruction method using ultrasound images as prior for regularization matrix

“…These measurements are then used to estimate (recover) optical proprieties of the tissue. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Minimal light absorption in this wavelength range, allows for several centimeters of light penetration in soft tissue, such as breast and brain. 3 Utilizing multiple wavelengths in the NIR range enables this technology to quantify tissue characteristics, such as oxygenated, deoxygenated, and total hemoglobin (HbO2, HbR, and HbT) concentrations as well as hemoglobin oxygen saturation (SO 2 ) and lipid and water concentrations.…”

Multiparametric Monitoring of Chemotherapy Treatment Response in Locally Advanced Breast Cancer Using Quantitative Ultrasound and Diffuse Optical Spectroscopy

“…Other strategies for combined systems include US-guided optical imaging, developed by Zhu et al, from the University of Connecticut [40,46,47]. These systems have been studied to measure NAC response in breast tumors.…”