Ultrasound-guided cutting biopsy for the diagnosis of hepatocellular carcinoma — a study based on 420 patients

Is tumor biopsy necessary?

“…In all, 340 articles were identified (Supporting Table 1); however, only 4 level 1b studies 10-13 and 5 level 3b studies [14][15][16][17][18] could ultimately be used to answer the questions (see Tables 1 and 2). Among the 4 level 1b studies, only the study by Durand et al 13 used a completely independent reference standard (ie, an explanted liver or resection specimen).…”

“…One requirement for inclusion was that all malignancies needed to be proven by histology, and the needle type and the followup had to be known as well. They excluded all case reports and patients with seeding after ethanol 19 (2008) Systematic review Histology 3a Durand et al 13 (2001) Prospective and consecutive Histology Good Yes 1b Caturelli et al 12 (2004) Prospective and consecutive Histology Good Yes 1b Huang et al 17 (1996) Retrospective and nonconsecutive Histology Good Yes 3b Takamori et al 24 (2000) Retrospective and nonconsecutive Histology Good Yes 3b Maturen et al 23 (2006) Retrospective and nonconsecutive Histology Good Yes 3b Kosugi et al 22 (2004) Retrospective and nonconsecutive Histology Good Yes 3b Kim et al 21 (2000) Retrospective and nonconsecutive Histology Good Yes 3b Chapoutot et al 20 (1999) Retrospective and nonconsecutive Histology Good Yes 3b Chang et al 26 injection and radiofrequency ablation and all patients with suspected intrahepatic seeding. Finally, they included 8 studies, which were mostly retrospective cross-sectional studies.…”

“…Finally, they included 8 studies, which were mostly retrospective cross-sectional studies. 12,13,17,[20][21][22][23][24] We identified 4 more studies. [25][26][27][28] Three of these studies were not analyzed because the reference standard was poorly defined 27,28 or some of the patients were not followed up.…”

Role of guided Fine needle aspiration cytology in diagnosis of abdominopelvic masses

“…The risk of needle tracking depends on size of the tumor, thickness of hepatic parenchyma, number of needle passes, tumor grade, and type of needle used. [15] In the present study population, no complications occurred during and after the procedure. The incidence of needle track seedling was 0.6% (one of 148 patients of HCC) in study done by Reddy et al [16] Among the 13 cases of ovarian masses, most common lesions were malignant (eight cases, 61.54%); a similar observation was made out in the study done by Sobha et al [17] (58.3%) and Pranab et al [18] (87.5%), which was different from the observation made by Sidhalingreddy and Andola.…”

Hepatocellular carcinoma – diagnostic dilemmas

“…Rola badania cytologicznego materiału pochodzącego z biopsji aspiracyjnej guza maleje wraz z zaawansowaniem nowych technik obrazowania wątroby. Należy mieć także na uwadze fakt, że wykonanie biopsji niesie ze sobą ryzyko wystąpienia krwawienia do jamy otrzewnej oraz rozsiewu komórek nowotworowych wzdłuż kanału wkłucia igły, które ocenia się w granicach 1,6-5% [26][27][28].…”