Ultrasound for Visualization and Modification of Brain Tissue

Fry, F. J.; Heimburger, Robert F.; Gibbons, Luke; Eggleton, R. C.

doi:10.1109/t-su.1970.29557

Cited by 17 publications

(7 citation statements)

References 1 publication

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“…The cranial bone attenuates, reflects and distorts the ultrasound waves (Fry et al 1970). Hence, bone constitutes a major obstacle for transcranial sonothrombolysis.…”

Section: 2 Mechanisms Of Thrombolytic Enhancementmentioning

confidence: 99%

Sonothrombolysis

Bader¹,

Bouchoux²,

Holland³

2016

Advances in Experimental Medicine and Biology

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Thrombo-occlusive disease is a leading cause of morbidity and mortality. In this chapter, the use of ultrasound to accelerate clot breakdown alone or in combination with thrombolytic drugs will be reported. Primary thrombus formation during cardiovascular disease and standard treatment methods will be discussed. Mechanisms for ultrasound enhancement of thrombolysis, including thermal heating, radiation force, and cavitation, will be reviewed. Finally, in-vitro, in-vivo and clinical evidence of enhanced thrombolytic efficacy with ultrasound will be presented and discussed.

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“…The cranial bone attenuates, reflects and distorts the ultrasound waves (Fry et al 1970). Hence, bone constitutes a major obstacle for transcranial sonothrombolysis.…”

Section: 2 Mechanisms Of Thrombolytic Enhancementmentioning

confidence: 99%

Sonothrombolysis

Bader¹,

Bouchoux²,

Holland³

2016

Advances in Experimental Medicine and Biology

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“…We investigate a bubble size range from 0.01 m to 50 m. The driving frequency used in all the simulations is 1 MHz. Other parameters used in the simulation are c L ϭ1600 m/s, ϭ0.0725 N/m, T ϱ ϭ20°C, p ϱ ϭ1 atm, and ϭ1100 kg/m 3 . These values correspond to the properties of tissuemimicking phantoms used in our experiments.…”

Section: Resultsmentioning

confidence: 99%

“…Biological, physical, and chemical effects due to high intensity ultrasound, sometimes coupled with cavitation activity, have been observed by several researchers who essentially established the field of therapeutic ultrasound. [1][2][3] In addition to causing mechanical damage, cavitation has been observed to affect and, under the right conditions, enhance heat deposition from ultrasound. 4 -9 The preceding list of work on bubble-enhanced heating was reviewed in Holt and Roy, 10 who also observed bubbleenhanced heating in an agar-based tissue-mimicking phantom from focused MHz-frequency ultrasound.…”

Section: Introductionmentioning

confidence: 99%

Bubble dynamics and size distributions during focused ultrasound insonation

Yang

Roy

Holt

2004

The Journal of the Acoustical Society of America

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The deposition of ultrasonic energy in tissue can cause tissue damage due to local heating. For pressures above a critical threshold, cavitation will occur, inducing a much larger thermal energy deposition in a local region. The present work develops a nonlinear bubble dynamics model to numerically investigate bubble oscillations and bubble-enhanced heating during focused ultrasound ͑HIFU͒ insonation. The model is applied to calculate two threshold-dependent phenomena occurring for nonlinearly oscillating bubbles: Shape instability and growth by rectified diffusion. These instabilities in turn are shown to place physical boundaries on the time-dependent bubble size distribution, and thus the thermal energy deposition.

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“…Therapeutic ultrasound came into earnest with William and Frank Fry at the University of Illinois (O' Brien and Dunn 2015). Their preliminary in vivo studies with focused sources (Fry 1952;Fry et al 1950Fry et al , 1970 culminated in the treatment of 88 patients with Parkinson's disease (Fry and Fry 1960) and cemented the use of ultrasound as a therapeutic modality.…”

Section: Know Thy Sound Fieldmentioning

confidence: 99%

For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy

Bader

Vlaisavljevich

Maxwell

2019

Ultrasound in Medicine & Biology

142

114

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Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of bubble clouds for tissue destruction. Although acoustic bubble activity is often characterized as chaotic, the short-duration histotripsy pulses produce a unique and consistent type of cavitation for tissue destruction. In this review, the action of histotripsyinduced bubbles is discussed. Sources of bubble nuclei are reviewed, and bubble activity over the course of single and multiple pulses is outlined. Recent innovations in terms of novel acoustic excitations, exogenous nuclei for targeted ablation and histotripsy-enhanced drug delivery and image guidance metrics are discussed. Finally, gaps in knowledge of the histotripsy process are highlighted, along with suggested means to expedite widespread clinical utilization of histotripsy.

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Ultrasound for Visualization and Modification of Brain Tissue

Cited by 17 publications

References 1 publication

Sonothrombolysis

Sonothrombolysis

Bubble dynamics and size distributions during focused ultrasound insonation

For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy

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