Ultrasound Examination Shows Disturbed Proximal Gastric Function in Symptomatic Gallstone Patients with Dyspepsia and Improvement after Cholecystectomy

Berhane, Tewelde; Hausken, Trygve; Ólafsson, Sigurđur; Søndenaa, Karl

doi:10.1055/s-2006-926797

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Others have suggested that cholecystectomy results in a faster gastric emptying time with normalization of gastric myoelectric activity (28). Studies suggest that there is disturbed proximal gastric function in symptomatic gallstone patients with dyspepsia which improves after cholecystectomy (29). More recent studies have suggested that laparoscopic cholecystectomy improves dyspeptic symptoms of abdominal pain, early satiety, nausea, and vomiting but does not alter gastric emptying (30).…”

Section: Discussionmentioning

confidence: 99%

Cholecystectomy and Clinical Presentations of Gastroparesis

et al. 2013

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Background Many patients with gastroparesis have had their gallbladder removed. Aim To determine if clinical presentations of patients with gastroparesis differ in those with prior cholecystectomy compared to patients who have not had their gallbladder removed. Methods Gastroparetic patients were prospectively enrolled into the NIDDK Gastroparesis Registry. Detailed history and physical examinations were performed; patients filled out questionnaires including Patient Assessment of GI Symptoms (PAGI-SYM). Results Of 391 subjects with diabetic (DG) or idiopathic gastroparesis (IG), 142 (36%) had a prior cholecystectomy at the time of enrollment. Patients with prior cholecystectomy were more often female, older, married, and overweight or obese. Cholecystectomy had been performed in 27/59 (46%) of T2DM compared to 19/78 (24%) T1DM and 96/254 IG (38%) (P=0.03). Patients with cholecystectomy had more comorbidities, particularly chronic fatigue syndrome, fibromyalgia, depression, and anxiety. Postcholecystectomy gastroparesis patients had increased health care utilization and had a worse quality of life. Independent characteristics associated with prior cholecystectomy included insidious onset (OR=2.06; p=0.01), more comorbidities (OR=1.26; P<0.001), less severe gastric retention (OR(severe)=0.68; overall P=0.03) and more severe symptoms of retching (OR=1.19; P=0.02) and upper abdominal pain (OR=1.21; P=0.02), less severe constipation symptoms (OR=0.84; P=0.02), and not classified as having IBS (OR=0.51; P=0.02). Etiology was not independently associated with a prior cholecystectomy. Conclusions Symptom profiles in patients with and without cholecystectomy differ: postcholecystectomy gastroparesis patients had more severe upper abdominal pain and retching and less severe constipation. These data suggest that prior cholecystectomy is associated with selected manifestations of gastroparesis.

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Section: Discussionmentioning

confidence: 99%

Cholecystectomy and Clinical Presentations of Gastroparesis

et al. 2013

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“…One of the risk factors to bezoar formation is delayed gastric emptying [ 9 ]. A few studies in the past have established gallstone disease to be a cause of delayed gastric emptying [ 11 - 13 ]. Ibrarullah et al hypothesised that this could be due to an effect of hormonal stimuli secreted from inflamed gallbladder wall mucosa that are linked to gastric motility, or due to a pyloroduodenal ileus as a consequence of inflammation in and outside the gallbladder, or even as a result of mechanical obstruction from pericholecystic adhesions secondary to recurrent cholecystitis [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Cholecystitis Masking a Gastric Bezoar

Chaudhry¹,

Iqbal²,

Malik³

2022

Cureus

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A bezoar is a solid mass of indigestible material that usually forms in the gastrointestinal (GI) tract. Gastric bezoars, located in the stomach, can present variably. They can be asymptomatic or present with GI symptoms like nausea, vomiting, abdominal pain, or more serious complications, such as GI obstruction or perforation. Diagnostic modalities are mainly radiological, and treatment may either be conservative or interventional. Herein, we disclose the case of a 47-year-old female who presented with a two-week history of abdominal pain with an incidental finding of a possible gastric phytobezoar, co-existing with gallbladder disease. Although not previously reported, this study highlights the possibility of an association between gallbladder disease and the formation of a bezoar.

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