Ultrasound evaluation of the fetal nasal bone: what is the most appropriate first-trimester cut-off point for aneuploidy screening?

Mazzoni, Gui Tarcisio; Cabral, Antônio Carlos Vieira; Faria, Marcos Murilo de Lima; Castro, Mário Jorge Barreto Viegas; Pires, Magda de Carvalho; Johnson, David Sidney Dantas; Pettersen, Heverton

doi:10.1007/s00404-011-2175-4

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…To date, in the first trimester, only the absence of NB has been consistently demonstrated to increase the risk of trisomy 21, whereas the clinical implications of NB hypoplasia have not been fully elucidated. In two independent studies, the presence of NB hypoplasia (length below the 10th centile) in the first trimester has not been found to correlate with the risk of aneuploidies as demonstrated in the second trimester . Conversely, other studies have shown a correlation between the sonographic demonstration of a hypoplastic NB in the first trimester and the risk of trisomy 21 .…”

Section: Discussionmentioning

confidence: 94%

The usefulness of volume NT software in measuring the fetal nasal bone at 11 to 13 + 6 weeks of gestation

et al. 2014

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Section: Discussionmentioning

confidence: 94%

The usefulness of volume NT software in measuring the fetal nasal bone at 11 to 13 + 6 weeks of gestation

et al. 2014

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“…Previously, first-trimester screening test parameters including nuchal translucency, serum fβ-hCG, PAPP-A and ductus venosus were investigated for their associations with adverse perinatal outcomes (1,2,4,5,11). NB is one of the additional parameters of the first-trimester screening test and usually its absence or hypoplasia is found to be associated with chromosomal abnormalities (6,12). However, the possible association of NBL and the adverse perinatal outcome has not yet been assessed.…”

Section: Discussionmentioning

confidence: 99%

Fetal Nasal Bone Length as a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy

2017

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Background:Adverse outcomes of pregnancy are a challenging health-care problem. Prediction of adverse pregnancy outcomes is important to prevent the morbidities of the foetus and the mother.Aims:To study the clinical interest of fetal nasal bone length in predicting adverse pregnancy outcomes in the first trimester of pregnancy.Study Design:A population-based retrospective cohort study.Methods:Data from 868 women with first-trimester fetal nasal bone length and birth records available were enrolled. Fetal nasal bone length percentiles were determined and evaluated for their ability to predict adverse pregnancy outcomes such as preterm birth, preterm labour, preterm premature rupture of membranes, early preterm birth, gestational diabetes mellitus, gestational hypertension-preeclampsia, small-for-gestational age foetuses, macrosomia, oligohydramnios, polyhydramnios and fetal distress.Results:Fetal nasal bone length >95th percentile was significantly associated with preterm labor and preterm premature rupture of membranes (p=0.02, accuracy 0.91 and p=0.001, accuracy 0.94, respectively), whereas nasal bone length >99th percentile was significantly associated with preterm labor and oligohydramnios (p=0.006, accuracy 0.95 and p=0.014, accuracy 0.97).Conclusion:Fetal nasal bone length at high percentiles in the first trimester of pregnancy may aid in the prediction of adverse outcomes such as preterm labour, preterm premature rupture of membranes and oligohydramnios.

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“…35 A small nose is a common facial feature of individuals with trisomy 21. 36 First-trimester nasal bone length has been proposed to be a component of aneuploidy screening. 37 Further, in 62.1% of fetuses with trisomy 21, the nasal bones were divergent, whereas in 131 of 135 (97.0%) euploid fetuses, the bones were entirely fused in the midline.…”

Section: Imaging Of the Profilementioning

confidence: 99%

Radiological evaluation of the fetal face using three-dimensional ultrasound imaging

Bäumler¹,

Bigorre²,

Faure³

2012

RMI

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This paper reviews screening and three-dimensional diagnostic ultrasound imaging of the fetal face. The different techniques available for analyzing biometric and morphological items of the profile, eyes, ears, lips, and hard and soft palate are commented on and briefly compared with the respective bi-dimensional techniques. The available literature supports the use of three-dimensional ultrasound in difficult prenatal diagnostic conditions because of its diagnostic accuracy, enabling improved safety of perinatal care. Globally, a marked increase has been observed in the accuracy of three-dimensional ultrasound in comparison with the bidimensional approach. Because there is no consensus about the performance of the different three-dimensional techniques, future studies are needed in order to compare them and to find the best technique for analysis of each of the respective facial elements. Universal prenatal standards may integrate these potential new findings in the future. At this time, the existing guidelines for prenatal facial screening should not be changed.

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Ultrasound evaluation of the fetal nasal bone: what is the most appropriate first-trimester cut-off point for aneuploidy screening?

Abstract: The best tool for aneuploidy screening was the qualitative NB test (absent vs. present). Ultrasonography of the NB is a component of aneuploidy screening, and should not be used alone.

Cited by 4 publications

References 12 publications

The usefulness of volume NT software in measuring the fetal nasal bone at 11 to 13 + 6 weeks of gestation

The usefulness of volume NT software in measuring the fetal nasal bone at 11 to 13 + 6 weeks of gestation

Fetal Nasal Bone Length as a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy

Radiological evaluation of the fetal face using three-dimensional ultrasound imaging

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