Ultrasound-driven electrical stimulation of peripheral nerves based on implantable piezoelectric thin film nanogenerators

Chen, Ping; Wu, Ping; Xiao, Wen‐Jing; Wang, Qiong; Xu, Chao; Yang, Ming; Feng, Jiexiong; Hu, Bin; Luo, Zhiqiang

doi:10.1016/j.nanoen.2021.106123

Cited by 96 publications

(74 citation statements)

References 44 publications

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“…Regulating neurobehavior shows great promise for therapeutic application in a variety of immunological diseases and clinical conditions ( 1 ). For examples, sepsis can be treated by electrical stimulation of the vagus nerve ( 1 ), and electrical stimulation can promote the flow of calcium ions into nerve cells and the synthesis and release of ATP ( 2 , 3 ). As a considerable member of endogenous danger-associated molecular pattern signaling molecule, extracellular ATP plays vital roles in natural immunity ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Pannexin1, Connexin32, and Connexin43 in Spotted Sea Bass (Lateolabrax maculatus): They Are Important Neuro-Related Immune Response Genes Involved in Inflammation-Induced ATP Release

et al. 2022

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Many immunological diseases can be treated by regulating neurobehavior, in which extracellular ATP is a vital member of endogenous danger-associated molecular pattern signaling molecule that plays a crucial part in innate neuro-related immunity. It is actively released through pannexin (Panx) and connexin (Cx) hemichannels from activated or stressed cells during inflammation, injury, or apoptosis. In addition to participating in ATP release, Panxs and Cxs also have crucial immune functions. In this study, pannexin1, three connexin32 isoforms and connexin43 were identified and characterized in spotted sea bass (Lateolabrax maculatus), which were named LmPanx1, LmCx32.2, LmCx32.3, LmCx32.7, and LmCx43. Their similar topological structures were discovered by sequence analysis: a relatively unconserved C-terminal region and four highly conserved transmembrane (TM) domains, and so on. Each extracellular (ECL) region of Panx1 has two conserved cysteine residues. Unlike Panx1, each ECL region of Cx32 and Cx43 contains three conserved cysteine residues, forming two conserved motifs: CX6CX3C motif in ECL1 and CX4CX5C motif in ECL2. Furthermore, Panx1 and Cx43 share similar genomic organization and synteny with their counterparts in selected vertebrates. Cx32 and CX43 were located in the same locus in fish, but diverged into two loci from amphibian. Moreover, despite varying expression levels, the identified genes were constitutively expressed in all examined tissues. All genes were upregulated by PAMP [lipopolysaccharide and poly(I:C)] stimulation or bacterial infection in vivo and in vitro, but they were downregulated in the brain at 6 or 12 h after stimulation. Especially, the three LmCx32 isoforms and LmCx43 were upregulated by ATP stimulation in primary head kidney leukocytes; however, downregulation of LmCx32.3 and LmCx43 expression were noted at 12 h. Conversely, ATP treatment inhibited the expression of LmPanx1. Importantly, we showed that the spotted sea bass Panx1, Cx43, and Cx32 were localized on the cellular membrane and involved in inflammation-induced ATP release. Taken together, our results demonstrated that Panx1, Cx32, and Cx43 are important neuro-related immune response genes involved in inflammation-induced ATP release.

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Section: Introductionmentioning

confidence: 99%

Characterization of Pannexin1, Connexin32, and Connexin43 in Spotted Sea Bass (Lateolabrax maculatus): They Are Important Neuro-Related Immune Response Genes Involved in Inflammation-Induced ATP Release

et al. 2022

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“…To further assess the cytotoxicity of the as‐synthesized MDABCO‐NH 4 I 3 film, a cell viability test has been conducted by using L929 fibroblasts. [ 23 , 59 ] In Figure 5b , the cell viability of control (0 µg mL −1 ) was set as 100%, while the medium containing 10% DMSO was used as the positive control. The cell viability of the group with maximum MDABCO‐NH 4 I 3 concentration at 100 µg mL −1 is 98.49 ± 4.30%, which is similar to the control group.…”

Section: Resultsmentioning

confidence: 99%

Metal‐Free Perovskite Piezoelectric Nanogenerators for Human–Machine Interfaces and Self‐Powered Electrical Stimulation Applications

Wei

Chen

et al. 2022

Advanced Science

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Single crystal metal-free halide perovskites have received great attention in recent years owing to their excellent piezoelectric and ferroelectric properties. However, the nanotoxicity and piezoelectricity within the nanoscale of such materials have yet been reported for the demonstration of practical applications. In this work, the observation of intrinsic piezoelectricity in metal-free perovskite (MDABCO-NH 4 I 3 ) films using piezoresponse force microscopy (PFM) is reported. A cytotoxicity test is also performed on MDABCO-NH 4 I 3 to evaluate its low-toxic nature. The as-synthesized MDABCO-NH 4 I 3 is further integrated into a piezoelectric nanogenerator (PENG). The MDABCO-NH 4 I 3 -based PENG (MN-PENG) exhibits optimal output voltage and current of 15.9 V and 54.5 nA, respectively. In addition, the MN-PENG can serve as a self-powered strain sensor for human-machine interface applications or be adopted in in vitro electrical stimulation devices. This work demonstrates a path of perovskite-based PENG with high performance, low toxicity, and multifunctionality for future advanced wearable sensors and portable therapeutic systems.

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“…Safety guidelines derived from non-therapeutic diagnostic ultrasound regulations specify that the maximum acoustic field in tissues is 720 mW cm −2 [141]. Ultrasonic interfaces are being actively explored as wireless interfaces for deeply implanted peripheral nerve stimulators and networks of brain recording motes [50][51][52][53][54][55][56][57]142,143]. Ultrasound has also been investigated for use in directly modulating neural activity, although the mechanism remains debated [144].…”

Section: (D) Ultrasoundmentioning

confidence: 99%

“…In this review, we provide an overview of recent advances in wireless interfaces for brain neurotechnologies. We introduce the requirements that modern brain-implanted devices impose on the wireless interface and discuss the working principles and relative advantages of modalities based on electromagnetic (EM) fields [32,[44][45][46][47][48][49], ultrasound [50][51][52][53][54][55][56][57] and light [33,[56][57][58][59][60][61][62][63][64][65][66][67]. We investigate major challenges for wireless interfaces based on radio-frequency and other modalities.…”

Section: Introductionmentioning

confidence: 99%

Wireless interfaces for brain neurotechnologies

Kim

2022

Phil. Trans. R. Soc. A.

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Wireless interfaces enable brain-implanted devices to remotely interact with the external world. They are critical components in modern research and clinical neurotechnologies and play a central role in determining their overall size, lifetime and functionality. Wireless interfaces use a wide range of modalities—including radio-frequency fields, acoustic waves and light—to transfer energy and data to and from an implanted device. These forms of energy interact with living tissue through distinct mechanisms and therefore lead to systems with vastly different form factors, operating characteristics, and safety considerations. This paper reviews recent advances in the development of wireless interfaces for brain neurotechnologies. We summarize the requirements that state-of-the-art brain-implanted devices impose on the wireless interface, and discuss the working principles and applications of wireless interfaces based on each modality. We also investigate challenges associated with wireless brain neurotechnologies and discuss emerging solutions permitted by recent developments in electrical engineering and materials science. This article is part of the theme issue 'Advanced neurotechnologies: translating innovation for health and well-being'.

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Ultrasound-driven electrical stimulation of peripheral nerves based on implantable piezoelectric thin film nanogenerators

Cited by 96 publications

References 44 publications

Characterization of Pannexin1, Connexin32, and Connexin43 in Spotted Sea Bass (Lateolabrax maculatus): They Are Important Neuro-Related Immune Response Genes Involved in Inflammation-Induced ATP Release

Characterization of Pannexin1, Connexin32, and Connexin43 in Spotted Sea Bass (Lateolabrax maculatus): They Are Important Neuro-Related Immune Response Genes Involved in Inflammation-Induced ATP Release

Metal‐Free Perovskite Piezoelectric Nanogenerators for Human–Machine Interfaces and Self‐Powered Electrical Stimulation Applications

Wireless interfaces for brain neurotechnologies

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