Ultrasound Doppler renal resistive index

Viazzi, Francesca; Leoncini, Giovanna; Derchi, Lorenzo E.; Pontremoli, Roberto

doi:10.1097/hjh.0b013e328365b29c

Cited by 126 publications

(47 citation statements)

References 35 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Currently, clinical studies have shown that detection of subtle changes in RI were associated with renal vascular tone during sepsis, acute kidney injury and stage of chronic kidney disease in patients with renal allograft [9, 11]. Additionally, RI could be used for the management of hypertensive patients [20]. In experimental studies, the adaptation of renal RI to facilitate detailed renal injury has been limited, primarily because of technical difficulties in imaging mice versus humans, including the small size of mice, the high heart rates of small animals, and the high speed for data acquisition and storage.…”

Section: Discussionmentioning

confidence: 99%

Renal Resistive Index as a Novel Indicator for Renal Complications in High-Fat Diet-Fed Mice

Lü

et al. 2017

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: The renal resistive index (RI) is a novel candidate as a renal injury prognostic indicator, but it remains unclear how renal RI levels correspond to renal injury in diabetic nephropathy. Methods: To examine this issue, we compared 8-week-old male C57BL/6 mice fed with high-fat diet (HFD) versus chow diet (CHD) for 16 weeks. At 8 and 12 weeks, the glomerular filtration rate (GFR), urinary albumin-to-creatinine ratio (UACR), and inflammatory factors (IL-1β, IL-6, TNFα, and MCP-1) were measured, along with the increase in renal RI. Results: Our study suggests RI values positively correlate with GFR for the first 12 weeks of HFD feeding. In contrast, the GFR of 16-week HFD feeding is lower than that of 12-week HFD feeding, whereas RI levels are significantly increased. Additionally, our study suggests RI values accurately indicate the renal fibrosis and renal injury in HFD-fed mice treated with lovastatin. Conclusion: This study seems to confirm the utility of a noninvasive and repeatable ultrasound parameter to rapidly evaluate renal fibrosis in a HFD-induced type 2 diabetic mouse model in vivo. This highly sensitive and comparable renal RI measurement could monitor the whole procedure of disease development in real-time. RI measurement of the renal artery is capable of differentiating responses to standard therapy with lovastatin in HFD-fed mice from the CHD group.

show abstract

Section: Discussionmentioning

confidence: 99%

Renal Resistive Index as a Novel Indicator for Renal Complications in High-Fat Diet-Fed Mice

Lü

et al. 2017

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…Duplex waveforms of the main, segmental, interlobar and arcuate arteries were assessed in the upper, mid and lower poles in both kidneys and peak systolic velocity, end diastolic velocity and resistive indices were measured simultaneously with GFR and RPF measurements. Renal resistive index was calculated as [(peak systolic velocity-end diastolic velocity)/peak systolic velocity] 20 . Two repeated measurements were taken from each renal artery; renal resistive index of each artery was reported as the mean value of these two measurements.…”

Section: Methodsmentioning

confidence: 99%

A Pilot Study to Evaluate Renal Hemodynamics in Cirrhosis by Simultaneous Glomerular Filtration Rate, Renal Plasma Flow, Renal Resistive Indices and Biomarkers Measurements

Mindikoğlu

Dowling²,

Wong-You-Cheong³

et al. 2014

Am J Nephrol

View full text Add to dashboard Cite

Background: Renal hemodynamic measurements are complicated to perform in patients with cirrhosis, yet they provide the best measure of risk to predict hepatorenal syndrome (HRS). Currently, there are no established biomarkers of altered renal hemodynamics in cirrhosis validated by measured renal hemodynamics. Methods: In this pilot study, simultaneous measurements of glomerular filtration rate (GFR), renal plasma flow (RPF), renal resistive indices and biomarkers were performed to evaluate renal hemodynamic alterations in 10 patients with cirrhosis (3 patients without ascites, 5 with diuretic-sensitive and 2 diuretic-refractory ascites). Results: Patients with diuretic-refractory ascites had the lowest mean GFR (36.5 ml/min/1.73 m²) and RPF (133.6 ml/min/1.73 m²) when compared to those without ascites (GFR 82.9 ml/min/1.73 m², RPF 229.9 ml/min/1.73 m²) and with diuretic-sensitive ascites (GFR 82.3 ml/min/1.73 m², RPF 344.1 ml/min/1.73 m²). A higher mean filtration fraction (FF) (GFR/RPF 0.36) was noted among those without ascites compared to those with ascites. Higher FF in patients without ascites is most likely secondary to the vasoconstriction in the efferent glomerular arterioles (normal FF ∼0.20). In general, renal resistive indices were inversely related to FF. While patients with ascites had lower FF and higher right kidney main and arcuate artery resistive indices, those without ascites had higher FF and lower right kidney main and arcuate artery resistive indices. While cystatin C and β₂-microglobulin performed better compared to Cr in estimating RPF, β-trace protein, β₂-microglobulin, and SDMA, and (SDMA+ADMA) performed better in estimating right kidney arcuate artery resistive index. Conclusion: The results of this pilot study showed that identification of non-invasive biomarkers of reduced RPF and increased renal resistive indices can identify cirrhotics at risk for HRS at a stage more amenable to therapeutic intervention and reduce mortality from kidney failure in cirrhosis.

show abstract

“…Furthermore, an increased RRI has been demonstrated to predict the onset of diabetes mellitus in patients with primary HT [8,10,12,13].…”

Section: Introductionmentioning

confidence: 99%

Renal resistive index in patients with true resistant hypertension: results from the RESIST-POL study

et al. 2016

View full text Add to dashboard Cite

A b s t r a c tBackground: Increased ultrasound Doppler renal resistive index (RRI) is a marker of atherosclerotic and hypertensive organ damage both at renal and systemic level. Aim:To evaluate RRI in patients with true resistant hypertension (TRHT) in the RESIST-POL study. Methods:From 204 patients diagnosed with TRHT in the RESIST-POL study, 151 patients (90 male, 61 female, mean age: 47.7 ± 10.4, range: 19-65 years) without secondary hypertension were included into the analysis. All patients were characterised by estimated glomerular filtration rate > 60 mL/min/1.73 m 2 and no history of diabetes prior to the study. As a control group we included 50 age-and gender-matched patients (35 male, 15 female, mean age: 46.8 ± 10.4, range: 19-65 years) with primary well-controlled hypertension. The groups also did not differ in respect to the number of years of known history of hypertension. The RRIs were evaluated on the basis of the Doppler ultrasound examination. Increased RRI was defined as ≥ 0.7. Results:Both groups did not differ in terms of renal function. Patients with TRHT were characterised by higher RRI as compared with the group with well-controlled hypertension (0.62 ± 0.05 vs. 0.60 ± 0.05, p < 0.05). In the TRHT group RRI correlated significantly with age, clinic and ambulatory blood pressure measurement, diastolic blood pressure (DBP) levels, as well as with clinic pulse pressure (PP) (r = 0.297; p = 0.001), with daytime (r = 0.355; p < 0.001) and nighttime (r = 0.313; p < 0.001) PP, and with fasting glucose concentration (r = 0.215; p = 0.008) and E/E' ratio (r = 0.289; p = 0.001) on echocardiography. RRI values were significantly higher in TRHT patients with newly diagnosed diabetes as compared with TRHT patients without diabetes (0.65 ± 0.05 vs. 0.62 ± 0.05, p = 0.022). Age, daytime DBP, daytime PP, and E/E' ratio but not fasting glucose concentration correlated independently with RRI in the model. Among patients with TRHT, patients with increased RRI were characterised by older age (52.2 ± 4.9 vs. 47.3 ± 10.6 years, p = 0.012), higher body mass index (32.8 ± 6.0 vs. 29.7 ± 4.5 kg/m 2 , p = 0.034), as well as lower daytime and nighttime DBP values and lower daytime and nighttime heart rate, as compared to patients with RRI < 0.7. The TRHT patients with increased RRI as compared to patients with RRI < 0.7 were characterised also by higher daytime and nighttime PP. Both groups did not differ in respect of renal function. Conclusions:Our study showed that the patients with TRHT were characterised by significantly higher RRI values as compared to the subjects with well-controlled hypertension. It may also be suggested that in the subjects with TRHT renal vascular resistance is related to blood pressure values, selected echocardiographic abnormalities, and some surrogate markers for metabolic and cardiovascular events, including fasting glucose plasma concentration and PP, respectively. www.kardiologiapolska.plRenal resistive index in patients with true resistant hypertension: results from the RESIST-POL...

show abstract

Ultrasound Doppler renal resistive index

Cited by 126 publications

References 35 publications

Renal Resistive Index as a Novel Indicator for Renal Complications in High-Fat Diet-Fed Mice

Renal Resistive Index as a Novel Indicator for Renal Complications in High-Fat Diet-Fed Mice

A Pilot Study to Evaluate Renal Hemodynamics in Cirrhosis by Simultaneous Glomerular Filtration Rate, Renal Plasma Flow, Renal Resistive Indices and Biomarkers Measurements

Renal resistive index in patients with true resistant hypertension: results from the RESIST-POL study

Contact Info

Product

Resources

About