Ultrasound contrast agents

Calliada, Fabrizio; Campani, R; Bottinelli, Olivia; Bozzini, Anna Carla; Sommaruga, Maria Grazia

doi:10.1016/s0720-048x(98)00057-6

Cited by 300 publications

(179 citation statements)

References 5 publications

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“…9,10 However, a new clinical approach consists in using microbubble contrast agents, such as Levovist, to increase acoustic signal sensitivity reflecting microvascular perfusion. [11][12][13] In order to predict antiangiogenic effects over a treatment period, contrast-enhanced HFCDUS was used in this study.…”

Section: Introductionmentioning

confidence: 99%

Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

et al. 2006

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Tumor growth is dependent both on endothelial and tumor cells. The aim of this study was to investigate dynamically whether changes in tumor vasculature implicate tumor tissue degeneration during antiangiogenic therapies. In order to quantify intra-tumor vascularization and necrosis, we have used ultrasound technology. This study has identified essential parameters needed to quantify specifically and sensitively the number of microvessels and the extent of necrosis in xenografted human carcinomas during natural tumor evolution, using contrast-enhanced high-frequency ultrasonography with (HFCDUS) or without (HFUS) color Doppler. We showed that quantification of intra-tumor microvessels between HFCDUS and immunohistochemistry is correlated using an anti-CD31 antibody. Furthermore, quantification of tumor necrosis with HFUS was confirmed by histological examination of hematoxylin-eosin-saffraninstained sections over the observation period. Subsequently, for the assessment of novel angiogenic inhibitors, HFCDUS and HFUS were used to elucidate the underlying dynamics linking vessel inhibition and tumor eradication. We describe a novel application for HFCDUS/HFUS that constitutes an effective, convenient, and non-invasive method for clinical assessment of angiogenic inhibitors. In conclusion, we showed that tumor cells abruptly became necrotic following an antivascular therapy, whereas untreated tumors were protected from degeneration by a significant blood supply.

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Section: Introductionmentioning

confidence: 99%

Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

et al. 2006

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“…With the use of filter techniques, the fundamental frequency is canceled out, allowing the second-harmonic portion to generate an image. [7][8][9][10][11] The use of these filtering techniques requires narrow harmonic bands, resulting in long ultrasonic pulses and leading to decreased spatial resolution. 12 A new technology, called phase inversion harmonic imaging, generates images by using 2 phase-inverted pulses sent one after the other.…”

mentioning

confidence: 99%

Detection of liver metastases: comparison of contrast‐enhanced wide‐band harmonic imaging with conventional ultrasonography.

Bernatik

Strobel²,

Hahn³

et al. 2001

J of Ultrasound Medicine

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Objective. To compare the detection rate of conventional ultrasonography and contrast-enhanced wide-band harmonic ultrasonographic imaging in the detection of small liver metastases. Methods. Consecutive patients with histologically proved gastrointestinal carcinoma liver metastases were studied. Biphasic helical computed tomography, conventional ultrasonography, and contrast-enhanced wide-band harmonic imaging were performed on all patients within a 5-day period. The biphasic helical computed tomographic scans were reviewed and interpreted by a skilled radiologist. The number of lesions and their descriptive characteristics were recorded for analysis. In addition, videotape recordings of the conventional ultrasonography and contrast-enhanced wide-band harmonic imaging were blindly reviewed, after which the number of detected lesions and their characteristics were then compared with those detected on biphasic helical computed tomography, considered the standard of reference. Results. Twenty-eight patients (10 female and 18 male; age range, 45-72 years) were studied. Conventional ultrasonography detected 37 (59%) of all lesions visualized by biphasic helical computed tomography. The detection rate for contrast-enhanced wide-band harmonic imaging was significantly higher (61 [97%] of 63). In our series, two 10-mm lesions near the diaphragm were not visualized by wide-band harmonic imaging. Conclusions. The use of contrast-enhanced imaging techniques significantly improves the ultrasonographic detection of liver metastases. Our results achieved the sensitivity of biphasic helical computed tomography.

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“…The AEI-High MI mode uses high intensity ultrasound waves to detect bubbles for loss of correlation (LOC) imaging. LOC imaging, also known as sonoscintigraphy or stimulated acoustic emission and transient scattering uses an ultrasound pulse which is powerful enough to destroy the bubbles and produces a strong backscatter echo (14). The hypothesis of the destruction of trapped air bubbles suggested by Lu et al (13) could be a possible explanation of the scintillation artifact; however, it might not be the only reason why the artifact is visible only on AEI-High MI mode and not on B-mode gray-scale imaging.…”

Section: Aei-high MI Ultrasound Mode For the Diagnosis Of Urolithiasismentioning

confidence: 99%

The usefulness of agent emission imaging - high mechanical index ultrasound mode in the diagnosis of urolithiasis: a prospective preliminary study

Salmaslıoğlu

Bulakçı

Bakir

et al. 2018

Diagn Interv Radiol

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Ultrasound contrast agents

Cited by 300 publications

References 5 publications

Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

Detection of liver metastases: comparison of contrast‐enhanced wide‐band harmonic imaging with conventional ultrasonography.

The usefulness of agent emission imaging - high mechanical index ultrasound mode in the diagnosis of urolithiasis: a prospective preliminary study

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