Ultrasound compatible RF ablation electrode design for catheter based guidance of RF ablation &amp;#x2014; In vivo results with thermal strain imaging

Stephens, Douglas N.; Cannata, J.M.; Seo, Chi Hyung; Jeong, Jong-Seob; Sun, Enwei; Cao, Wenwu; Nikoozadeh, Amin; Oralkan, Ömer; Rama, Alan de la; Nguyen, Tho; Dentinger, Aaron; Lin, Feng Han; Park, Suhyun; Wildes, Douglas; Thomenius, Kai E.; Shung, K. Kirk; Shivkumar, Kalyanam; Mahajan, Aman; Truong, Uyen; O’Donnell, Matthew; Khuri-Yakub, Pierre; Sahn, David J.

doi:10.1109/ultsym.2010.5935664

Cited by 2 publications

(2 citation statements)

References 10 publications

(7 reference statements)

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“…The ML‐CMUT catheter was used with the specially developed UCRA tip to compare its general TSI capability to that of the ML‐PZT version of the catheter. Details of ML‐PZT use with this tip are reported in related works 45 , 46…”

Section: Resultsmentioning

confidence: 99%

First In Vivo Use of a Capacitive Micromachined Ultrasound Transducer Array–Based Imaging and Ablation Catheter

Stephens¹,

Truong²,

Nikoozadeh³

et al. 2012

J of Ultrasound Medicine

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Objectives The primary objective was to test in vivo for the first time the general operation of a new multifunctional intracardiac echocardiography (ICE) catheter constructed with a microlinear capacitive micromachined ultrasound transducer (ML-CMUT) imaging array. Secondarily, we examined the compatibility of this catheter with electroanatomic mapping (EAM) guidance and also as a radiofrequency ablation (RFA) catheter. Preliminary thermal strain imaging (TSI)-derived temperature data were obtained from within the endocardium simultaneously during RFA to show the feasibility of direct ablation guidance procedures. Methods The new 9F forward-looking ICE catheter was constructed with 3 complementary technologies: a CMUT imaging array with a custom electronic array buffer, catheter surface electrodes for EAM guidance, and a special ablation tip, that permits simultaneous TSI and RFA. In vivo imaging studies of 5 anesthetized porcine models with 5 CMUT catheters were performed. Results The ML-CMUT ICE catheter provided high-resolution real-time wideband 2-dimensional (2D) images at greater than 8 MHz and is capable of both RFA and EAM guidance. Although the 24-element array aperture dimension is only 1.5 mm, the imaging depth of penetration is greater than 30 mm. The specially designed ultrasound-compatible metalized plastic tip allowed simultaneous imaging during ablation and direct acquisition of TSI data for tissue ablation temperatures. Postprocessing analysis showed a first-order correlation between TSI and temperature, permitting early development temperature-time relationships at specific myocardial ablation sites. Conclusions Multifunctional forward-looking ML-CMUT ICE catheters, with simultaneous intracardiac guidance, ultrasound imaging, and RFA, may offer a new means to improve interventional ablation procedures.

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Section: Resultsmentioning

confidence: 99%

First In Vivo Use of a Capacitive Micromachined Ultrasound Transducer Array–Based Imaging and Ablation Catheter

Stephens¹,

Truong²,

Nikoozadeh³

et al. 2012

J of Ultrasound Medicine

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“…However, the low resolution and expensive specialized equipment limits the use of MRI-based RFA procedures. An ultrasound integrated RFA electrode probe for RFA procedure guidance has been reported [16,17], but the image resolution and contrast is low. An M-scan ultrasound integrated RFA catheter has been proposed to assess the lesion formation and prevent complications from steam pops in real time [18,19].…”

Section: Introductionmentioning

confidence: 99%

Integrated RFA/PSOCT catheter for real-time guidance of cardiac radio-frequency ablation

Zhao¹,

Fu²,

Blumenthal³

et al. 2018

Biomed. Opt. Express

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Radiofrequency ablation (RFA) is an important standard therapy for cardiac arrhythmias, but direct monitoring of tissue treatment is currently lacking. We demonstrate an RFA catheter integrated with polarization sensitive optical coherence tomography (PSOCT) for directly monitoring the RFA process in real time. The integrated RFA/OCT catheter was modified from a standard clinical RFA catheter and includes a miniature forward-viewing cone-scanning OCT probe. The PSOCT system was validated with a quarter-wave plate while the RFA function of the integrated catheter was validated by comparing lesion sizes with those made with an unmodified RFA catheter. Additionally, the integrated catheter guided catheter-tissue apposition and monitored RFA lesion formation in cardiac tissue in real time. The results show that catheter-tissue contact can be characterized by observing the features of the blood and tissue in the acquired OCT images and that RFA lesion formation can be confirmed by monitoring the change in phase retardance in the acquired PSOCT images. This system demonstrates the feasibility of an integrated RFA/OCT catheter to deliver RF energy and image the cardiac wall simultaneously and justifies further research into use of this technology to aid RFA therapy for cardiac arrhythmias.

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Ultrasound compatible RF ablation electrode design for catheter based guidance of RF ablation — In vivo results with thermal strain imaging

Cited by 2 publications

References 10 publications

First In Vivo Use of a Capacitive Micromachined Ultrasound Transducer Array–Based Imaging and Ablation Catheter

First In Vivo Use of a Capacitive Micromachined Ultrasound Transducer Array–Based Imaging and Ablation Catheter

Integrated RFA/PSOCT catheter for real-time guidance of cardiac radio-frequency ablation

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