Ultrasound combined with biochemical parameters can predict parathyroid carcinoma in patients with primary hyperparathyroidism

Liu, Ruifeng; Xia, Yu; Chen, Cheng; Ye, Tiantian; Huang, Xingfu; Ma, Li; Hu, Ya; Jiang, Yuxin

doi:10.1007/s12020-019-02069-7

Cited by 14 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with parathyroid carcinoma manifest symptoms similar to those of typical PHPT patients; hence, biochemical markers are essential signs of suspicion of carcinoma. Several studies have focused on predicting parathyroid carcinoma preoperatively and concluded that the serum ALP level has the best capability to predict parathyroid carcinoma based on the AUC value in the ROC curve, followed by the serum PTH level; serum calcium had the lowest value of all three parameters (37)(38)(39). In this study, five of the 14 patients with parathyroid carcinoma have undergone en bloc resection at initial surgery, and no recurrence was observed during the period of follow-up.…”

Section: Discussionmentioning

confidence: 71%

Clinical Characteristics of Primary Hyperparathyroidism: 15-Year Experience of 457 Patients in a Single Center in China

et al. 2021

View full text Add to dashboard Cite

ObjectivePrimary hyperparathyroidism (PHPT) is a common endocrine disorder of calcium metabolism. However, data concerning a large cohort of PHPT patients in the Chinese population are scarce. Thus, the objective of this study was to determine the general clinical signatures of 457 Chinese PHPT patients and explore the clinical characteristic differences between benign and malignant PHPT.MethodsA single-center retrospective study was designed. Medical records between preoperation and postoperative follow-up, were assessed and statistical analysis of the clinical data was performed.ResultsPatients with PHPT aged 12–87 years, with a mean onset age of 56.16 ± 14.60 years, were included. Most patients (68.7%) in our center had symptomatic patterns described as bone pain (74.8%), urolithiasis (25.5%), fatigue (17.5%), and pathological fracture (13.1%), but an increasing tendency has been established in the proportion of patients with asymptomatic forms. Correlation analysis revealed that patients with higher serum levels of parathyroid hormone (PTH) and calcium presented higher serum levels of bone turnover markers (BTMs) and lower 25-hydroxy-vitamin D (25OHD) values (P<0.001). Gains in bone mineral density (BMD) at L1–4, the femoral neck and the total hip were observed 1–2 years after parathyroidectomy (9.6, 5.9, and 6.8%). Parathyroid carcinoma patients presented prominently higher serum PTH and calcium levels and BTMs and lower BMD at femoral neck and total hip than benign PHPT patients (P<0.05), while no significant differences in age, sex, and serum 25OHD concentration were observed between benign and malignant PHPT patients.ConclusionsPHPT should be paid attention to in the patients with bone pain. While, BMD and BTMs can differentiate parathyroid carcinoma from parathyroid adenoma and hyperplasia to some extent. In addition, anti-osteoporosis drugs could be used when necessary to avoid hip fractures in patients with parathyroid carcinoma.

show abstract

Section: Discussionmentioning

confidence: 71%

Clinical Characteristics of Primary Hyperparathyroidism: 15-Year Experience of 457 Patients in a Single Center in China

et al. 2021

View full text Add to dashboard Cite

show abstract

“…More specific markers of PC are required for preoperative differential diagnosis since PA could be accompanied by severe course of PHPT with severe hypercalcemia and a significant increase in PTH, and vice versa, PC with a mild course and even normocalcaemia. A logistic regression models seem to be more reliable with the inclusion of several clinical important parameters for preoperative diagnostics (including serum calcium, PTH, but not limited to them) 36,37 . In the present pilot study, circulating miRNA was proposed as a potential surrogate marker of the PC.…”

Section: Discussionmentioning

confidence: 85%

“…A logistic regression models seem to be more reliable with the inclusion of several clinical important parameters for preoperative diagnostics (including serum calcium, PTH, but not limited to them). 36,37 In the present pilot study, circulating miRNA was proposed as a potential surrogate marker of the PC. Indeed, the AUCs of miRNA-342-3p, serum calcium and PTH levels are equivalent; in the same time, the combination of them appears to be the most promising preoperative models to distinguish the PC from the PA in individuals with increased risk of malignant tumour.…”

Section: Ta B L E 1 Clinical Biochemical Histological and Genetic Characteristics Of The Patientsmentioning

confidence: 97%

Serum circulating miRNA‐342‐3p as a potential diagnostic biomarker in parathyroid carcinomas: A pilot study

Krupinova

Мокрышева

Petrov

et al. 2021

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

Parathyroid carcinoma (PC) is a rare and aggressive malignancy, accounting for less than 1% of primary hyperparathyroidism (PHPT) and only 0.005% of all cancers. 1,2 Five-year survival rates, as pooled from different registries and case series, are in the range of 76%-85%, with 10-year survival rates being between 49% and 77%. 3,4 Recurrence occurs in more than half of PC cases, with the five-year survival rate in patients with metastatic disease being less than 50%. 5,6 Reports from the United States, Australia, Finland and the

show abstract

“…DeLellis reported a case with metastatic parathyroid carcinoma in the lung, which was indistinguishable from a parathyroid adenoma, suggesting that oval or round nodules with sharp demarcation could be recurrent or metastatic tumors of PC as well [14]. Nonetheless, most recurrent PC lesions still exhibit an infiltrative boundary, especially those with large sizes, showing that the margin features align with the primary PC lesions [15]. Color Doppler revealed marked vascularity in most of the targeted lesions.…”

Section: Discussionmentioning

confidence: 97%

Locoregional recurrence of parathyroid carcinoma: how to identify this rare but fatal condition using ultrasonography

et al. 2021

Self Cite

View full text Add to dashboard Cite

Parathyroid carcinoma (PC) is a rare condition with propensity to relapse. The purpose of this study was to evaluate the sonographic findings of locoregional recurrences of parathyroid carcinoma, in order to facilitate diagnosis of this condition using ultrasound (US). This was a retrospective observational study including 21 patients confirmed with pathologically confirmed locoregional recurrence of parathyroid carcinoma. All patients had undergone preoperative US examination at a tertiary center. The imaging, clinical and laboratory data of each case were collected. Sonographic appearance of the largest lesion at each recurrence was evaluated by two experienced radiologists according to a pre-agreed protocol. Overall, 29 relapses occurred in 21 patients. The median age of the patients was 45 years (range 24-71 years). The median size of the largest recurrent lesion at each relapse was 1.8 cm (range 0.8-3.8 cm). Ultrasound images showed hypoechoic solid nodules in 28 relapses (96.6%), inhomogeneous echo-texture in 28 relapses (96.6%), intralesional echogenic septa-like structures in 21 relapses (72.4%), intralesional cystic change in two relapses (6.9%), infiltrative or blurred boundary in 20 relapses (69.0%), irregular shape in 22 relapses (75.9%), marked vascularization on color Doppler imaging in 19 relapses (65.5%), multiple lesions in 26 relapses (89.7%), contralateral recurrence in 3 relapses (10.3%), and subcutaneous recurrence in 10 relapses (34.5%). None of the recurrent lesions exhibited calcification. The total size of all the recurrent lesions at each relapse fairly correlated with the serum intact parathyroid hormone levels (r = 0.450; p = 0.014).

show abstract

Ultrasound combined with biochemical parameters can predict parathyroid carcinoma in patients with primary hyperparathyroidism

Cited by 14 publications

References 25 publications

Clinical Characteristics of Primary Hyperparathyroidism: 15-Year Experience of 457 Patients in a Single Center in China

Clinical Characteristics of Primary Hyperparathyroidism: 15-Year Experience of 457 Patients in a Single Center in China

Serum circulating miRNA‐342‐3p as a potential diagnostic biomarker in parathyroid carcinomas: A pilot study

Locoregional recurrence of parathyroid carcinoma: how to identify this rare but fatal condition using ultrasonography

Contact Info

Product

Resources

About