Ultrasound characteristics combined with gamma-glutamyl transpeptidase for diagnosis of biliary atresia in infants less than 30 days

Wang, Guotao; Zhang, Nan; Zhang, Xiaoer; Zhou, Wenying; Xie, Xiaoyan; Zhou, Luyao

doi:10.1007/s00383-021-04923-0

Cited by 10 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, further US examination is still necessary due to its low specificity. 25 Previously, we mentioned that gallbladder abnormalities and TC thickness are the two most important US features in the diagnosis of BA and that the combination of these two features could obtain the most powerful diagnostic performance. In this study, the combination of gallbladder abnormalities and the TC sign yielded a sensitivity of 92.0% and specificity of 94.3%, which was similar to that reported in most previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…In total, 376 patients were excluded based on the following reasons: (1) did not undergo US examination ( n = 68); (2) did not have clinical laboratory results ( n = 96); and (3) had an unclear final diagnosis ( n = 212). Of the finally enrolled patients, 60 patients from Hospital A were previously reported 25 . The flow chart of this study is shown in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

“…Of the finally enrolled patients, 60 patients from Hospital A were previously reported. 25 The flow chart of this study is shown in Figure 1.…”

Section: Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Gamma‐Glutamyl Transferase Combined With Conventional Ultrasound Features in Diagnosing Biliary Atresia

Weng

Zhou

et al. 2022

J of Ultrasound Medicine

Self Cite

View full text Add to dashboard Cite

Objectives To develop and validate a biliary atresia (BA) diagnostic score based on serum gamma‐glutamyl transferase (GGT) levels and conventional ultrasound features for discriminating BA in patients with jaundice from two centers. Methods A total of 958 patients from one hospital were classified as the derivation cohort, and 725 patients from another hospital were classified as the validation cohort. The optimal GGT cutoff value for diagnosing BA was calculated in the derivation cohort and subsequently verified in the validation cohort. Gallbladder abnormalities and the triangular cord (TC) sign were evaluated in all patients. A BA diagnostic score was developed for diagnosing BA using the GGT levels, gallbladder abnormalities and the TC sign based on the data from the derivation cohort followed by external validation. Results Based on the optimal cutoff value 350.0 U/L, GGT yielded a sensitivity of 59.3% and specificity of 85.4% in diagnosing BA. The area under the receiver operating characteristic curve (AUC 0.724) was inferior to that of the gallbladder (AUC 0.911, P < .001) and comparable to that of the TC sign (AUC 0.771, P = .128). The combination of GGT and ultrasound diagnosis could help to reduce the misdiagnosis of 9 infants with BA. The BA diagnostic score yielded a sensitivity of 93.3% and specificity of 95.0% with the highest AUC in this study (0.941). Conclusions GGT can add diagnostic value to ultrasound examination when diagnosing BA. The BA diagnostic score based on GGT, gallbladder abnormalities and the TC sign shows satisfactory discrimination abilities in BA.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Gamma‐Glutamyl Transferase Combined With Conventional Ultrasound Features in Diagnosing Biliary Atresia

Weng

Zhou

et al. 2022

J of Ultrasound Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Previous studies have reported a triangular sign to be more sensitive (58%-100%) and specific (83%-100%) for the prediction of BA, while others say report gallbladder abnormalities (short, lack of lumen) to be more sensitive (50%–100%) and specific (82%–95%)[ 43 ]. There are reports of 100% sensitivity and NPV in the identification of BA together with gallbladder anomalies and GGT[ 44 ]. In our series, GGT, pale stool and abnormal ultrasonography had maximum sensitivity and PPV (sensitivity and PPV were both 95%, diagnostic accuracy 70%)[ 22 ].…”

Section: Biliary Atresiamentioning

confidence: 99%

Biliary atresia and congenital disorders of the extrahepatic bile ducts

İşlek¹,

Tümgör²

2022

WJGPT

View full text Add to dashboard Cite

“…Higher AUC could be obtained when modified TC thickness combined with the gallbladder abnormalities [ 20 , 21 , 27 , 28 ]. Furthermore, the combination of the modified TC sign, gallbladder classification scheme and GGT level with a cut off-value of 188 IU/L could yielded the sensitivity of 100.0% in the diagnosis of BA among infants less than 30 days [ 29 ]. This finding was of great value for the early diagnosis of BA.…”

Section: Conventional Ultrasoundmentioning

confidence: 99%

Ultrasound for the Diagnosis of Biliary Atresia: From Conventional Ultrasound to Artificial Intelligence

Zhou

2021

Diagnostics

Self Cite

View full text Add to dashboard Cite

Biliary atresia is an aggressive liver disease of infancy and can cause death without timely surgical intervention. Early diagnosis of biliary atresia is critical to the recovery of bile drainage and long-term transplant-free survival. Ultrasound is recommended as the initial imaging strategy for the diagnosis of biliary atresia. Numerous ultrasound features have been proved helpful for the diagnosis of biliary atresia. In recent years, with the help of new technologies such as elastography ultrasound, contrast-enhanced ultrasound and artificial intelligence, the diagnostic performance of ultrasound has been significantly improved. In this review, various ultrasound features in the diagnosis of biliary atresia are summarized. A diagnostic decision flow chart for biliary atresia is proposed on the basis of the hybrid technologies, combining conventional ultrasound, elastography and contrast-enhanced ultrasound. In addition, the application of artificial intelligence in the diagnosis of biliary atresia with ultrasound images is also introduced.

show abstract

Ultrasound characteristics combined with gamma-glutamyl transpeptidase for diagnosis of biliary atresia in infants less than 30 days

Cited by 10 publications

References 25 publications

Gamma‐Glutamyl Transferase Combined With Conventional Ultrasound Features in Diagnosing Biliary Atresia

Gamma‐Glutamyl Transferase Combined With Conventional Ultrasound Features in Diagnosing Biliary Atresia

Biliary atresia and congenital disorders of the extrahepatic bile ducts

Ultrasound for the Diagnosis of Biliary Atresia: From Conventional Ultrasound to Artificial Intelligence

Contact Info

Product

Resources

About