Ultrasound bone mass in schizophrenic patients on antipsychotic therapy

Rey-Sánchez, Purificación; Lavado‐García, Jesus M.; Canal-Macias, Maria L.; Gómez-Zubeldia, M.A.; Roncero-Martín, Raúl; Pedrera‐Zamorano, Juan D.

doi:10.1002/hup.984

Cited by 38 publications

(60 citation statements)

References 29 publications

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“…Two recent meta-analyses have indicated significantly lower serum -25 hydroxy vitamin D (S-25 OH D) in patients with established psychiatric disorders compared to healthy controls (Belvederi Murri et al, 2013;Valipour et al, 2014), in line with previous studies showing an association between lower S-25 OH D and having a diagnosis in the schizophrenia spectrum (Rey-Sanchez et al, 2009;Partti et al, 2010). Correspondingly, in a study of diagnostically diverse psychiatric out-patients the lowest S-25 OH D levels were found in patients with schizophrenia or autism spectrum disorders (Humble et al, 2010).…”

Section: Introductionsupporting

confidence: 79%

“…This first finding is in contrast to earlier case-control studies including patients with established psychotic disorders (Rey-Sanchez et al, 2009;Partti et al, 2010;Itzhaky et al, 2012;Jamilian et al, 2013). These previous studies however have methodological limitations, including lack of adjustment for ethnicity (Rey-Sanchez et al, 2009;Partti et al, 2010;Doknic et al, 2011;Jamilian et al, 2013), comparison between hospitalized patients and health care workers (Itzhaky et al, 2012) or hospitalized patients and healthy controls recruited by advertisements without control for place of residence (Crews et al, 2013).…”

Section: Discussionmentioning

confidence: 53%

“…These previous studies however have methodological limitations, including lack of adjustment for ethnicity (Rey-Sanchez et al, 2009;Partti et al, 2010;Doknic et al, 2011;Jamilian et al, 2013), comparison between hospitalized patients and health care workers (Itzhaky et al, 2012) or hospitalized patients and healthy controls recruited by advertisements without control for place of residence (Crews et al, 2013). The healthy controls in the current study were randomly recruited from the same catchment area as the study patients and matched both for ethnicity and other important confounding variables such as gender and age.…”

Section: Discussionmentioning

confidence: 98%

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Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Nerhus

Berg

Dahl

et al. 2015

Psychiatry Research

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Vitamin D deficiency is common among patients with psychotic disorders and could be due to unknown disease mechanisms or contingent factors. However most studies are performed in chronic patients and have often failed to address the influence of ethnicity on vitamin D levels in clinical samples. We investigated serum concentrations of 25-hydroxy vitamin D (S-25 OH D) in first episode patients compared to patients with multi episodes and healthy controls; with a specific focus on differences between visible ethnic minorities and participants from the majority population. A total of 284 participants were included in this cross-sectional study. First episode patients with a DSM-IV psychotic disorder were matched on age, gender and ethnicity to participants from a multi episode patient sample (1:1) and healthy controls (1:2). We did not find any differences between either patient groups or the healthy controls, but participants from visible ethnic minorities had significantly lower S-25 OH D than participants from the majority population. This implies that S-25 OH D should be routinely measured in persons from visible ethnic minorities since low levels are associated with higher levels of depressive symptoms.

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Section: Introductionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 98%

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Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Nerhus

Berg

Dahl

et al. 2015

Psychiatry Research

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“…However, there is evidence to suggest that vitamin D among people with psychosis is correlated with the season of blood sampling (Belzeaux et al, 2015;Berg et al, 2010;Crews et al, 2013;Grønli et al, 2014;Lally et al, 2016;Zhu et al, 2015) and parathyroid hormone levels (Bergemann et al, 2008;Rey-Sánchez et al, 2009;Schneider et al, 2000), the latter being negatively correlated to vitamin D. What this review highlights are a multitude of variables that have been found to not significantly correlate with vitamin D within the patient population including but not limited to: BMI, age, gender, smoking, duration of illness and GAF score.…”

Section: Discussionmentioning

confidence: 99%

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Adamson

Lally

Gaughran

et al. 2017

Psychiatry Research

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(199/ 200)People with psychosis have high prevalence of low vitamin D levels but the correlates and relevance of this deficiency are unclear. A systematic search of major databases from inception to 03/2016 was undertaken investigating correlates of vitamin D in people with psychosis. Data was summarised with a best evidence synthesis. Across 23 included studies (n=1,770 psychosis, n= 8,171 controls) a mean difference in vitamin D levels between both groups of -11.14 ng/ml 0.59 was found.

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“…For example, bone mass is reduced in female patients with schizophrenia being treated with antipsychotic drugs. This is evidently associated with the drug-induced hyperprolactinaemia that causes a reduction in 25-hydroxy vitamin D concentrations (Rey-Sanchez et al, 2008). This is an example of the complications that contribute to the physical ill health and to the increased morbidity and mortality of patients with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

The metabolic syndrome in schizophrenia: is inflammation a contributing cause?

2012

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This non-systematic review of the literature summarizes the evidence that inflammation plays a major role in the psychopathology of schizophrenia and in the mechanisms that contribute to physical ill health that is commonly associated with schizophrenia. The impact of prenatal infections on the developing brain, the possible genetic link between the human lymphocyte antigen gene, inflammation, heart disease and diabetes, together with the increase in pro-inflammatory cytokines in the blood and cerebrospinal fluid provide convincing evidence that inflammation is a major factor in the pathology of this disorder. The changes in immune-related markers and specific neurotransmitters associated with the positive symptoms of schizophrenia are described. In addition, the possible mechanism whereby structural changes occur in the brain is associated with the neurotoxic effects of pro-inflammatory cytokines, together with the neurotoxic metabolites from the tryptophan-kynurenine pathway that is activated by pro-inflammatory cytokines, is also discussed. The role of effective antipsychotic drug treatment in attenuating the inflammatory response is described. However, evidence is limited regarding the causal connection between atypical antipsychotic drugs and the changes in glucose and lipid metabolism that could trigger the onset of physical ill health, including diabetes and heart disease. Indeed, there is evidence that there is a metabolic predisposition to diabetes in patients with schizophrenia that is exacerbated by obesity and thereby contributes to cardiovascular disease and other co-morbid illnesses. It is concluded that the effects of inflammatory mediators on the brain causally contribute to the pathology of schizophrenia and the ill health that accompanies the disorder.

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Ultrasound bone mass in schizophrenic patients on antipsychotic therapy

Abstract: Schizophrenic women in treatment with antipsychotic drugs had a loss of phalangeal bone mass that was associated with the levels of vitamin D or PTH, and increased bone turnover.

Cited by 38 publications

References 29 publications

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

The metabolic syndrome in schizophrenia: is inflammation a contributing cause?

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