Ultrasound‐assisted Synthesis of Novel Pyrazole and Pyrimidine Derivatives as Antimicrobial Agents

Abstract

Herein, we report a convenient and facile methodology for the synthesis of new series of pyrazole and pyrimidine derivatives 2a–f and 3a–f under ultrasound irradiation. Pyrazole and pyrimidine derivatives have been synthesized in better yields and shorter reaction times compared with the conventional method. The chemical structures of all the synthesized compounds were elucidated by their IR, 1H NMR, 13C NMR, MS, and elemental analysis. Further, the target compounds were screened for their antimicrobial activity against four bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) and two fungi (Candida albicans, Aspergillus niger). In particular, compounds 2a, 2d, 2e, 3a, 3e, and 3f exhibited potent antimicrobial activity.

Synthesis and In Vitro Anticancer Activities of New 1,4‐Disubstituted‐1,2,3‐triazoles Derivatives through Click Approach

“…[13] Azoles are one of the important classes of five-membered nitrogen-containing heterocycles. [14][15][16][17][18][19][20][21] The nitrogen-containing azoles have an important effect on structural modifications and biological interactions because of the advantage of two nitrogen heteroatoms in the ring. There are different types of azoles such as imidazole, triazole, tetrazole, and pentazole.…”

Efficient Rapid Access to Biginelli for the Multicomponent Synthesis of 1,2,3,4-Tetrahydropyrimidines in Room-Temperature Diisopropyl Ethyl Ammonium Acetate

“…The pyrimidine moiety is an essential part of RNA and DNA, providing various biological properties such as potent fungicide and bactericide . Some pyrimidine analogues are also known to acquire anticancer, antimalarial, antiviral, antibacterial, , antifungal, , anticonvulsant, and antihistamine activities. Certain 3,4-dihydropyrimidines have developed as essential props of numerous calcium antihypertensive agents, adrenergic, channel blockers, and neuropeptide antagonists .…”

Peel Extract Associated Oxidative Green Dakin Synthesis of Some Phenols Using Aqueous Banana Extract Catalyst

“…In the continuation of our previous work [11][12][13][14][15][16][17][18][19][20][21][22][23] , it was confirmed that until now none of the methods had used such a mild and green catalyst and solvents for Dakin oxidation. The designed method is suitable for the conversion of substituted benzaldehydes to its consequent substituted phenols.…”