Ultrasound Assisted Synthesis of 1,5-Disubstituted Tetrazoles Containing Propargyl or 2-Azidophenyl Moieties via Ugi-Azide Reaction

Rentería-Gómez, Manuel A.; Solorio-Alvarado, César R.; Gámez-Montaño, Rocı́o

doi:10.3390/ecsoc-25-11758

Cited by 1 publication

(3 citation statements)

References 21 publications

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“…Isocyanide-based multicomponent reactions(IMCR)combined with Pictet-Spengler reaction have been used for the synthesis of dihydropyrrolo[1,2-a]quinoxaline-amidines (31) involving the reaction of isonitriles,1-(2-aminophenyl)pyrroles (30) and aldehydes under microwave irradiation in DCE as solvent using p-TSA as catalyst(Yield~63-89 %). [28] (Scheme 12)…”

Section: Synthesis Ofdihydropyrrolo[12-a]quinoxaline-amidinesmentioning

confidence: 99%

“…Different review articles relating to the synthesis of quinoxalines [10,25–36] . have appeared in the literature, but in these review articles the update information relating to the synthetic methods involving isocyanide based multicomponent reactions have not been addressed, although some representative methods have been included up to some extent.…”

Section: Introductionmentioning

confidence: 99%

“…[15] Different review articles relating to the synthesis of quinoxalines. [10,[25][26][27][28][29][30][31][32][33][34][35][36] have appeared in the literature, but in these review articles the update information relating to the synthetic methods involving isocyanide based multicomponent reactions have not been addressed, although some representative methods have been included up to some extent. The present review article includes update information on the synthetic methods involving isocyanide based multicomponent reactions in the construction of structurally diverse heterocyclic scaffolds, quinoxalines and fused quinoxalines.…”

Section: Introductionmentioning

confidence: 99%

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Advances in Isocyanide‐Based Multicomponent Synthesis of Quinoxaline Scaffolds

Agarwal,

Verma,

Pathak

et al. 2023

ChemistrySelect

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The present review article includes recent advances in the synthesis of structurally and functionally diversified quinoxalines‐drug‐like small molecules with molecular complexity. We have extended our efforts to include the research work concerning the isocyanide‐based multicomponent reactions. The synthetic methods included in the present review article will provide an access for a diverse range of natural product mimetic scaffolds with the use of isocyanide‐.based combinatorial synthesis. These isocyanide based reactions will be significant for the synthesis of complex bioactive natural products and potential synthetic pharmaceuticals. The present review will contribute considerably to the organic syntheses and particularly drug discovery research including pharmaceutical and medicinal chemistry. Academically, the present review article will be interesting for the researchers engaged in design and development of isocyanide‐based organic transformations. Moreover, we hope that the isocyanide‐based multicomponent reactions will find major applications in industrially significant organic transformations and to develop new synthetic routes to facilitate the incorporation of heterocyclic substructures into pharmaceutically active molecules.

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Section: Synthesis Ofdihydropyrrolo[12-a]quinoxaline-amidinesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%