Ultrasound-assisted photothermal therapy and real-time treatment monitoring

Kim, Haemin; Jo, Gyuwon; Chang, Jin Ho

doi:10.1364/boe.9.004472

Cited by 16 publications

(9 citation statements)

References 32 publications

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“…In addition to destroying tumor tissues, HIFU has a superior hemostatic effect, which is effective in treating internal bleeding caused by the rupture of large blood vessels. Clinical applications of HIFU include treatment for benign or malignant tumors (e.g., liver cancer, pancreatic cancer, and sarcoma) as well as hemostasis, thrombolysis, and drug and gene delivery [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Cylindrical Piezoelectric and Specific Multi-Channel Circular MEMS-Transducer Array Resonator of Ultrasonic Ablation

2021

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Background: A cylindrical piezoelectric element and a specific multi-channel circular microelectromechanical systems (MEMS)-transducer array of ultrasonic system were used for ultrasonic energy generation and ablation. A relatively long time is required for the heat to be conducted to the target position. Ultrasound thermal therapy has great potential for treating deep hyperplastic tissues and tumors, such as breast cancer and liver tumors. Methods: Ultrasound ablation technology produces thermal energy by heating the surface of a target, and the heat gradually penetrates to the target’s interior. Beamforming was performed to observe energy distribution. A resonance method was used to generate ablation energy for verification. Energy was generated according to the coordinates of geometric graph positions to reach the ablation temperature. Results: The mean resonance frequency of Channels 1–8 was 2.5 MHz, and the cylindrical piezoelectric ultrasonic element of Channel A was 4.2546 Ω at 5.7946 MHz. High-intensity ultrasound has gradually been applied in clinical treatment. Widely adopted, ultrasonic hyperthermia involves the use of high-intensity ultrasound to heat tissues at 42–45 °C for 30–60 minutes. Conclusion: In the ultrasonic energy method, when the target position reaches a temperature that significantly reduces the cell viability (46.9 °C), protein surface modification occurs on the surface of the target.

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Section: Discussionmentioning

confidence: 99%

Investigation of Cylindrical Piezoelectric and Specific Multi-Channel Circular MEMS-Transducer Array Resonator of Ultrasonic Ablation

2021

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“…The laser pulse repetition rate was 10 Hz and the energy density was measured at 4.23 mJ/cm 2 in front of the optical fibers. Detailed experimental arrangement could be found in [41].…”

Section: Photoacoustic Protocols Ex-vivomentioning

confidence: 99%

PMP(Porphyrin–Micelle–PSMA) Nanoparticles for Photoacoustic and Ultrasound Signal Amplification in Mouse Prostate Cancer Xenografts

et al. 2021

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Photoacoustic (PA) imaging is used widely in cancer diagnosis. However, the availability of PA agents has not made great progress due to the limitations of the one currently in use, porphyrin. Porphyrin–Micelle (PM), developed by synthesizing porphyrin and PEG-3.5k, confirmed the amplification of the PA agent signal, and added binding affinity in an LNCaP model by attaching prostate-specific membrane antigen PSMA. Compared to the previously used porphyrin, a superior signal was confirmed, and the potential of PMP was confirmed when it showed a signal superior to that of hemoglobin at the same concentration. In addition, in the in vivo mouse experiment, it was confirmed that the signal in the LNCaP xenograft model was stronger than that in the PC-3 xenograft model, and the PMP signal was about three times higher than that of PM and porphyrin.

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“…At 5 s after the HIFU insonation, the echogenicity change indicated by the dashed white arrows and the tissue boundary were clearly observed (see Figure 5c). The hyperechoic spot appearing during the HIFU exposure (indicated by the dashed circle in Figure 5d) is mainly due to microbubbles induced by the HIFU [7,22] and partially acoustic impedance change of the region due to coagulation [23,24]. Since some microbubbles disappear without tissue damage after cessation of the HIFU exposure [22], the size of the hyperechoic spot may not match the actual size of the coagulation lesion measured in the tissue (see Figure 6).…”

Section: Real-time Hifu Treatment Monitoringmentioning

confidence: 99%

Real-Time HIFU Treatment Monitoring Using Pulse Inversion Ultrasonic Imaging

2018

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Real-time monitoring of high-intensity focused ultrasound (HIFU) surgery is essential for safe and accurate treatment. However, ultrasound imaging is difficult to use for treatment monitoring during HIFU surgery because of the high intensity of the HIFU echoes that are received by an imaging transducer. Here, we propose a real-time HIFU treatment monitoring method based on pulse inversion of imaging ultrasound; an imaging transducer fires ultrasound twice in 0° and 180° phases for one scanline while HIFUs of the same phase are transmitted in synchronization with the ultrasound transmission for imaging. By doing so, HIFU interferences can be eliminated after subtracting the two sets of the signals received by the imaging transducer. This function was implemented in a commercial research ultrasound scanner, and its performance was evaluated using the excised bovine liver. The experimental results demonstrated that the proposed method allowed ultrasound images to clearly show the echogenicity change induced by HIFU in the excised bovine liver. Additionally, it was confirmed that the moving velocity of the organs in the abdomen due to respiration does not affect the performance of the proposed method. Based on the experimental results, we believe that the proposed method can be used for real-time HIFU surgery monitoring that is a pivotal function for maximized treatment efficacy.

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Ultrasound-assisted photothermal therapy and real-time treatment monitoring

Cited by 16 publications

References 32 publications

Investigation of Cylindrical Piezoelectric and Specific Multi-Channel Circular MEMS-Transducer Array Resonator of Ultrasonic Ablation

Investigation of Cylindrical Piezoelectric and Specific Multi-Channel Circular MEMS-Transducer Array Resonator of Ultrasonic Ablation

PMP(Porphyrin–Micelle–PSMA) Nanoparticles for Photoacoustic and Ultrasound Signal Amplification in Mouse Prostate Cancer Xenografts

Real-Time HIFU Treatment Monitoring Using Pulse Inversion Ultrasonic Imaging

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