2022
DOI: 10.1016/j.crfs.2022.05.013
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Ultrasound-assisted pH-shifting remodels egg-yolk low-density lipoprotein to enable construction of a stable aqueous solution of vitamin D3

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Cited by 19 publications
(14 citation statements)
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“…Numerous studies have reported that the solubility of macromolecules or lipid-soluble small molecules in aqueous solutions usually increases substantially under strongly alkaline conditions (pH 12.0). For example, Ye et al reported that the remodeling of LDL molecules induced by pH-shifting was to realize the loading of VD 3 on LDL molecules, thereby constructing an aqueous solution in which VD 3 was stably dissolved ( Ye et al, 2022 ).…”
Section: Discussionmentioning
confidence: 99%
“…Numerous studies have reported that the solubility of macromolecules or lipid-soluble small molecules in aqueous solutions usually increases substantially under strongly alkaline conditions (pH 12.0). For example, Ye et al reported that the remodeling of LDL molecules induced by pH-shifting was to realize the loading of VD 3 on LDL molecules, thereby constructing an aqueous solution in which VD 3 was stably dissolved ( Ye et al, 2022 ).…”
Section: Discussionmentioning
confidence: 99%
“…Multivariate statistical analyses, including PCA and OPLS-DA, were used to distinguish differences in the porcine liver lipidome [ 40 ]. A one-way analysis of variance was used for the comparison of lipid species among groups in GraphPad Prism 8.0 [ 41 , 42 ]. DALs between the groups were screened according to a fold change ≤0.5 or ≥2 and variable importance in projection >1.…”
Section: Methodsmentioning
confidence: 99%
“…Prism 8.0 (GraphPad, La Jolla, CA) was employed for statistical analyses using the paired t -test. p < 0.05 were considered significant …”
Section: Methodsmentioning
confidence: 99%