Ultrasound-assisted one-pot four-component synthesis of novel 2-amino-3-cyanopyridine derivatives bearing 5-imidazopyrazole scaffold and their biological broadcast

Hirshfeld Surface, Molecular Docking Study, Spectroscopic Characterization and NLO Profile of 2‐Methoxy‐4,6‐Diphenylnicotinonitrile

“…Compounds incorporating pyridine derivative are a very interesting therapeutic agents which possess significant and versatile biological and pharmacological activities . Nicotinamide and nicotinic acid derivatives, which are used as food additives, are based on pyridine core structure .…”

“…Nicotinamide and nicotinic acid derivatives, which are used as food additives, are based on pyridine core structure . 2‐Amino‐3‐cyanopyridine derivatives are valuable heterocyclic compounds possessed broadcast biological activity and due to its chelating agent ability it can be used as ligand in organometallic chemistry . The title compound 2‐methoxy‐4,6‐diphenylnicotinonitrile was obtained according to the reported method by the reaction of α , β ‐unsaturated ketone with malononitrile in the presence of sodium methoxide and absolute methanol .…”

Recent Progress on Nicotinonitrile Scaffold‐based Anticancer, Antitumor, and Antimicrobial Agents: A Literature Review

“…Kalaria et al . prepared a series of 2‐amino‐3‐nicotinonitriles 279 and 280 by one‐pot four‐component cyclocondensation reaction of pyrazole‐4‐carbaldehyde 276a , b , malononitrile, ammonium acetate, and methyl ketones 277a – f and 278a – d under ultrasonic irradiation (Scheme ) . The 2‐amino‐3‐nicotinonitriles 279 and 280 were screened for their in vitro antimicrobial activity.…”

“…The 2‐amino‐3‐nicotinonitriles 279 and 280 were screened for their in vitro antimicrobial activity. The result showed that compounds 279e , 279h , 279l , 280c , 280g , and 280h exhibited excellent antibacterial activity and compounds 276a , 279k , 280a , and 280b showed moderate antituberculosis activity as compared with the first‐line drugs (Scheme ) .…”

Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs

“…In continuation of our efforts to synthesize some novel heterocyclic motifs with biological interest [27][28][29][30][31][32][33][34][35][36][37][38][39][40], herein we report the design, synthesis, antimicrobial evaluation, cytotoxicity and genotoxicity of quinoline based 1,2,4-oxadiazole scaffold. Potent 1,2,4-oxadiazole moiety is linked to quinoline moiety at C-3 position to observe the synergistic effect of these rings towards antimicrobial activity.…”