Ultrasound-assisted one-pot, four component synthesis of 4-aryl 3,4-dihydropyridone derivatives

Abstract

The condensation of Meldrum's acid, aromatic aldehydes, alkyl acetoacetates and ammonium acetate in glacial acetic acid under ultrasound irradiation at room temperature results in the formation of 3,4-dihydropyridone derivatives (4a-p) in 85-96% yields. Compared with conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction times and higher yields.

Solvent-free highly regioselective Michael addition of phenytoin to α,β-unsaturated esters in the presence of TBAB under ultrasound irradiation

“…Therefore, recently, ultrasonic irradiation technique has received considerable attention of researchers. [21][22][23][24][25] In continuation of our ongoing research on the Michael addition of imides and amides to unsaturated systems, 26,27 we report here an efficient strategy for synthesis of a series of DPH derivatives by Michael addition of this compound to α,β-unsaturated esters under ultrasound irradiation (Scheme 2).…”

Synthesis of 1‐amidoalkyl‐2‐naphthol derivatives using a magnetic nano‐Fe3O4@SiO2@Hexamethylenetetramine‐supported ionic liquid as a catalyst under solvent‐free conditions

“…In addition, the reactions carried out in synthesis of organic compounds should be fast and facile, and the obtained products should be easily separated and purified after the synthesis. So, the implementation of new procedures and strategies is required for these reasons …”

Ultrasound-assisted one-pot multi-component synthesis of 2-pyrrolidinon-3-olates catalyzed by Co3O4@SiO2core–shell nanocomposite

“…Furthermore, MCRs are easy to perform, inexpensive, quick, energy efficient and experimental procedures are relatively simple (1). Recently, the application of ultrasonic irradiation in chemical syntheses has received much attention (2)(3)(4)(5). On the other hand, designing MCRs under ultrasonic irradiation is another attractive area in synthetic organic chemistry.…”