Ultrasound‐Assisted Multicomponent Reactions, Organometallic and Organochalcogen Chemistry

Abstract

In the last two decades, the search for sustainability in chemical reactions has attached a lot of attention. In this focus review, the use of ultrasound (US) as an alternative energy source in organic synthesis is presented. The improvement of the performance of chemical reactions due to the cavitation effect has been previously studied and described. The use of US guarantees often higher yields than other green methodologies, as microwave or ball milling. The impressive positive effect of US in organic synthesis are demonstrated in this review mainly in organometallic and multi-component reactions (MCRs), aimed to prepare bioactive compounds. A particular attention is dedicated to the US-assisted synthesis of valuable organochalcogen compounds with pharmacological activity.[a] F.

Ultrasound-assisted multicomponent synthesis of 4H-pyrans in water and DNA binding studies

“…In particular, ultrasounds have been used in many transformations. Although this source of energy is a field in continuous growth in organic chemistry, in general, its use in multicomponent reactions has been less explored so far 65 – 67 .…”

Dichalcogenides/Oxone®‐Mediated Cyclization of (Z)‐Chalcogenoenynes under Ultrasound Irradiation

“…[2,3] This eco-friendly approach has been explored in several organic reactions, such multicomponent, alkylation, condensation and cycloaddition ones, as well as, in organometallic and organochalcogen chemistry. [4][5][6][7][8] This alternative reaction condition has been used to prepare heterocycles of chemical and medicinal interests. [9][10][11][12][13][14] It is important to highlight that under ultrasound irradiation, a specific activation occurs, which is based on acoustic cavitation and in some cases is able to modify the course of reactions, while improving yields and reducing the reaction times.…”

Effect of Ultrasound on the Green Selective Oxidation of Benzyl Alcohol to Benzaldehyde

“…Sonochemistry is the use of power ultrasound (US) as an activation method to perform chemical reactions [4]. It can induce changes of reactivity, enhance transformations by improving yields or selectivity, reduce duration time, and eventually replace hazardous reagents with harmless ones [5,6,7,8,9].…”