Ultrasound-assisted drug delivery with targeted-microbubbles in blood vessels on a chip

Park, Yoonjee C.; Zhang, Chentian; Mohamedi, Graciela; Kim, Sudong; Jeon, Nooli; Cleveland, Robin O.; Nagy, Jon O.; Wong, Joyce Y.

doi:10.1109/nebec.2014.6972899

Cited by 1 publication

(1 citation statement)

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“…Liposphere (AAL) linked superparamagnetic iron oxide (SPIO) particle-coated microbubbles have been produced in flow-focusing devices, which are then used for multimode imaging and drug delivery [38]. In addition, Park et al [79] produced drug-loaded and targeted microbubbles using a microfluidic device that delivered drugs in vitro to blood vessels. Using US, these drugloaded targeted microbubbles were found to selectively kill the cells on the vessel wall.…”

Section: Various Other Functionsmentioning

confidence: 99%

A novel technology: microfluidic devices for microbubble ultrasound contrast agent generation

Lin

Chen

2016

Med Biol Eng Comput

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Microbubbles are used as ultrasound contrast agents, which enhance ultrasound imaging techniques. In addition, microbubbles currently show promise in disease therapeutics. Microfluidic devices have increased the ability to produce microbubbles with precise size, and high monodispersity compared to microbubbles created using traditional methods. This paper will review several variations in microfluidic device structures used to produce microbubbles as ultrasound contrast agents. Microfluidic device structures include T-junction, and axisymmetric and asymmetric flow-focusing. These devices have made it possible to produce microbubbles that can enter the vascular space; these microbubbles must be less than 10 μm in diameter and have high monodispersity. For different demands of microbubbles production rate, asymmetric flow-focusing devices were divided into individual and integrated devices. In addition, asymmetric flow-focusing devices can produce double layer and multilayer microbubbles loaded with drug or biological components. Details on the mechanisms of both bubble formation and device structures are provided. Finally, microfluidically produced microbubble acoustic responses, microbubble stability, and microbubble use in ultrasound imaging are discussed.

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Section: Various Other Functionsmentioning

confidence: 99%