Ultrasound-assisted deep eutectic solvent extraction of echinacoside and oleuropein from Syringa pubescens Turcz.

Wang, Xinsheng; Wu, You; Li, Jie; Wang, Aoxiang; Li, Guangyao; Ren, Xueli; Wu, Yin

doi:10.1016/j.indcrop.2020.112442

Cited by 52 publications

(30 citation statements)

References 38 publications

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“…Moreover, ethanol extraction for 24 h got a similar TPC yield compared to UAE-DES for only 21 min, indicating that the UAE-DES was not only a time-saving but also an efficient approach. Similarly, in many studies, the application of UAE-DES provided a green and highly efficient extraction method for bioactive compounds from plant materials than conventional methods [ 40 , 41 , 42 ]. For antioxidant activity, UAE-DES also produced higher FRAP, DPPH, and ABTS values than UAE-ethanol, ethanol, and hot water extraction, which may be related to the higher content of polyphenols in the tea extract obtained by UAE-DES, consistent with previous studies that demonstrated that polyphenols were the main contributors to antioxidant activities of teas [ 28 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

Green Extraction of Antioxidant Polyphenols from Green Tea (Camellia sinensis)

Luo

Zhang

et al. 2020

Antioxidants

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In this study, the feasibility of improving the extraction yield of green tea antioxidant polyphenols by the combination of ultrasound-assisted extraction (UAE) and deep eutectic solvents (DESs) was investigated. Choline chloride (ChCl)-glycerol was selected as the best DES among 12 ChCl-based DESs to extract tea antioxidant polyphenols. Subsequently, the influences of extraction parameters on total phenolic content (TPC) values were investigated, and liquid/solid ratio, ultrasonic power, and ultrasonic time were optimized based on the response surface methodology. The optimal extraction conditions were a liquid to solid ratio of 36:1 (mL/g), ultrasonic power of 461.5 W, and ultrasonic time of 21 min, with the highest TPC value of 243 ± 7 mg gallic acid equivalent (mg GAE)/g dry weight (DW), which was 13% higher than that before optimization. In addition, under the optimal extraction conditions, tea polyphenolic extract exhibited higher antioxidant activity compared with conventional extraction methods. Four major catechins in the green tea extracts, including (−)-epicatechin (EC), (−)-epigallocatechin (EGC), (−)-epicatechin gallate (ECG) and (−)-epigallocatechin gallate (EGCG) were identified and quantified by high-performance liquid chromatography. In addition, scanning electron microscopy (SEM) analysis revealed that UAE-DES effectively disrupted the green tea leaf cells, thereby improving tea polyphenol yield. In summary, UAE-DES is an ideal green extraction method for the extraction of tea antioxidant polyphenols.

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Section: Resultsmentioning

confidence: 99%

Green Extraction of Antioxidant Polyphenols from Green Tea (Camellia sinensis)

Luo

Zhang

et al. 2020

Antioxidants

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“…Normally, the binding active sites of the ligands docked with the receptors can affect the catalytic ability of the enzyme. With regard to the main phenolics/acarbose docked with α-glucosidase, the numbers of binding sites ranked in the following order: acarbose ( 13 ) > procyanidin B1 ( 12 ) > arbutin ( 10 ) > chlorogenic acid ( 9 ) > (–)-epicatechin ( 8 ) > (+)-catechin ( 6 ); the number of formed H-bonds ranked as follows: acarbose ( 10 ) > chlorogenic acid ( 9 ) = procyanidin B1 ( 9 ) > (–)-epicatechin ( 7 ) = arbutin ( 7 ) > (+)-catechin ( 5 ). There was a significant positive relationship between the number of H-bonds and binding active sites residues with α-GIA.…”

Section: Resultsmentioning

confidence: 99%

“…In general, recovering compounds from the agro-industrial by-products or plant matrix is performed using organic solvents. Although organic solvents extract bio-active components, they have inevitable shortcomings, such as toxicity, non-degradability, low boiling points, and high flammability (4)(5)(6)(7)(8). Currently, deep eutectic solvents (DESs) are synthesized with hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs) under a low melting temperature.…”

Section: Introductionmentioning

confidence: 99%

LC-Q-Orbitrap-MS/MS Characterization, Antioxidant Activity, and α-Glucosidase-Inhibiting Activity With In Silico Analysis of Extract From Clausena Indica (Datz.) Oliv Fruit Pericarps

Wang

et al. 2021

Front. Nutr.

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Clausena indica (Datz.) Oliv fruit pericarps (CIOPs) is an important agro-industrial by-product rich in active components. In this article, the effects of traditional and green deep eutectic solvents (DESs) on the high-performance liquid chromatography (HPLC) characterization, antioxidant activities, and α-glucosidase-inhibitory activity of phenolic extracts from CIOPs were investigated for the first time. The results showed that ChCl-Gly and Bet-CA had higher extraction efficiency for the total phenolic content (TPC, 64.14–64.83 mg GAE/g DW) and total flavonoid content (TFC, 47.83–48.11 mg RE/g DW) compared with the traditional solvents (water, methanol, and ethyl acetate). LC-Q-Orbitrap-MS/MS was adopted to identify the phenolic compositions of the CIOPs extracts. HPLC-diode array detection (HPLC-DAD) results indicated that arbutin, (–)-epigallocatechin, chlorogenic acid, procyanidin B1, (+)-catechin, and (–)-epicatechin were the major components for all extracts, especially for deep eutectic solvents (DESs). In addition, ChCl-Xyl and ChCl-Gly extracts showed higher antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS+•), ferric reducing antioxidant power (FRAP), reducing power (RP), and cupric ion reducing antioxidant capacity (CUPRAC) than extracts extracted by other solvents. A strong α-glucosidase-inhibiting activity (IC50, 156.25-291.11 μg/ml) was found in three DESs extracts. Furthermore, in silico analysis of the major phenolics in the CIOPs extracts was carried out to explore their interactions with α-glucosidase. Multivariate analysis was carried out to determine the key factors affecting the antioxidant activity and α-glucosidase-inhibiting activity. In short, DES can be taken as a promising solvent for valorization and recovery of bioactive compounds from agro-industrial by-products. The results verified that CIOPs can be used as a prospective source rich in bio-active compounds applied in the food and pharmacy industries.

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“…In recent years, a great deal of research has shown that ultrasonic extraction is one of the ideal methods to extract natural active ingredients. It not only has the characteristics of high efficiency, simple operation, and short time but also has obvious advantages in protecting the chemical structure and biological activity of active components [ 24 , 25 ]. In this paper, ultrasound power (100 W, 150 W, 200 W, 250 W, and 300 W), an important parameter for ultrasonic extraction, was checked.…”

Section: Resultsmentioning

confidence: 99%

Analysis of Antioxidant Capacity of Chromones in Saposhnikoviae Radix Obtained by Ultrasonic-Assisted Deep Eutectic Solvents Extraction

Yue

Xu²,

et al. 2020

Journal of Analytical Methods in Chemistry

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In this paper, ultrasonic-assisted deep eutectic solvent (DES) extraction was applied to the acquisition of chromones (cimicifugin, prim-o-glucosylcimifugin, and 5-o-methylvisamminoside) from Saposhnikoviae radix (SR). The extraction effects of 11 prepared DESs were screened taking contents of chromones as indexes. Furthermore, the optimum extraction conditions were confirmed using a single-factor test and response surface optimization test. Scavenging activities of DPPH anion and ABTS cation radicals of different SR extracts (DES, methanol, and ethanol) were studied. The analysis results of best extraction conditions optimized by Design-Expert software were as follows: extraction time (40 min), extraction temperature (60°C), and the solid/liquid ratio (32 mL/g). Scavenging rates of the DES extract for DPPH anion radical and ABTS cation radical were found to be 75.31% and 65.71%, which were higher than those of methanol and ethanol extracts. In conclusion, the developed extraction method can be regarded as a safe, green, and more effective approach for the extraction of chromones in SR.

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Ultrasound-assisted deep eutectic solvent extraction of echinacoside and oleuropein from Syringa pubescens Turcz.

Cited by 52 publications

References 38 publications

Green Extraction of Antioxidant Polyphenols from Green Tea (Camellia sinensis)

Green Extraction of Antioxidant Polyphenols from Green Tea (Camellia sinensis)

LC-Q-Orbitrap-MS/MS Characterization, Antioxidant Activity, and α-Glucosidase-Inhibiting Activity With In Silico Analysis of Extract From Clausena Indica (Datz.) Oliv Fruit Pericarps

Analysis of Antioxidant Capacity of Chromones in Saposhnikoviae Radix Obtained by Ultrasonic-Assisted Deep Eutectic Solvents Extraction

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