Ultrasound-assisted catalyst-free thiol-yne click reaction in chitosan chemistry: Antibacterial and transfection activity of novel cationic chitosan derivatives and their based nanoparticles

Kritchenkov, Andreii S.; Egorov, Anton R.; Artemjev, Alexey A.; Kritchenkov, Ilya S.; Волкова, О. В.; Kurliuk, Aleh V.; Shakola, Tatsiana V.; Рубаник, В. В.; Tskhovrebov, Alexander G.; Yagafarov, Niyaz Z.; Khrustalev, Victor N.

doi:10.1016/j.ijbiomac.2019.11.241

Cited by 32 publications

(19 citation statements)

References 55 publications

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“…Safety is especially important for a delivery carrier, and some studies have indicated that the cellular damage caused by nanoparticles should be of great concern [23][24][25][26]. In our and others' previous work, it has been proved by both in vitro and in vivo cytotoxicity tests that chitosan-based nanoparticles are safe and can be well degraded within a certain concentration range [16,21,[27][28][29]. In the present study, we focused on the side effect of the O-2'-HACC/pFDNA, and the results of in vitro and in vivo cytotoxicity showed that the O-2'-HACC/pFDNA was safe within a certain concentration range.…”

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confidence: 89%

Intranasal immunization with O-2′-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles loaded with Newcastle disease virus DNA vaccine enhances mucosal immune response in chickens

et al. 2021

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Background There has been a great interest in developing strategies for enhancing antigen delivery to the mucosal immune system as well as identifying mucosal active immunostimulating agents. To elevate the potential of O-2ʹ-Hydroxypropyl trimethyl ammonium chloride chitosan (O-2ʹ-HACC) as an adjuvant and mucosal immune delivery carrier for DNA vaccine, we prepared the O-2ʹ-HACC loaded with Newcastle disease virus (NDV) F gene plasmid DNA and C3d6 molecular adjuvant (O-2ʹ-HACC/pFDNA microparticles). Results The O-2ʹ-HACC/pFDNA exhibited a regular spherical morphology with a particle size of 202.3 ± 0.52 nm, a zeta potential of 50.8 ± 8.21 mV, encapsulation efficiency of 90.74 ± 1.10%, and a loading capacity of 49.84 ± 1.20%. The plasmid DNA could be sustainably released from the O-2ʹ-HACC/pFDNA after an initial burst release. Intranasal vaccination of chickens immunized with O-2ʹ-HACC/pFDNA not only induced higher anti-NDV IgG and sIgA antibody titers but also significantly promoted lymphocyte proliferation and produced higher levels of IL-2, IL-4, IFN-γ, CD4+, and CD8 + T lymphocytes compared with the NDV commercial live attenuated vaccine. Intranasal delivery of the O-2ʹ-HACC/pFDNA enhanced humoral, cellular, and mucosal immune responses and protected chickens from the infection of highly virulent NDV compared with the intramuscular delivery. Conclusions Collectively, our findings indicated that the O-2ʹ-HACC could be used as a vaccine adjuvant and delivery system for mucosal immunity and have an immense application promise. Graphic Abstract

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confidence: 89%

Intranasal immunization with O-2′-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles loaded with Newcastle disease virus DNA vaccine enhances mucosal immune response in chickens

et al. 2021

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“…The AgNPs-chitosan/montmorillonite nanocomposite films may control the morphological characteristics of AgNPs besides the significant inhibition of E. coli and B. subtilis [ 36 ]. Tripolyphosphate (TPP) was added to the chitosan film as a crosslinker and a reducing agent of the silver nanoparticles agent, while Chitosan(CS)-based NPs have shown a tremendous potential as an antibacterial agent [ 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 ]. CS/TPP-AgNPs film inhibited S. aureus and E. coli more efficiently compared to the effect of chitosan films alone [ 172 ].…”

Section: Antimicrobial Nanomedicine Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Antimicrobial Nano-Drug Delivery Systems

et al. 2022

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Infectious diseases are among the major health issues of the 21st century. The substantial use of antibiotics over the years has contributed to the dissemination of multidrug resistant bacteria. According to a recent report by the World Health Organization, antibacterial (ATB) drug resistance has been one of the biggest challenges, as well as the development of effective long-term ATBs. Since pathogens quickly adapt and evolve through several strategies, regular ATBs usually may result in temporary or noneffective treatments. Therefore, the demand for new therapies methods, such as nano-drug delivery systems (NDDS), has aroused huge interest due to its potentialities to improve the drug bioavailability and targeting efficiency, including liposomes, nanoemulsions, solid lipid nanoparticles, polymeric nanoparticles, metal nanoparticles, and others. Given the relevance of this subject, this review aims to summarize the progress of recent research in antibacterial therapeutic drugs supported by nanobiotechnological tools.

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“…The study performed by Ejaz et al is an example of such applications, as they developed mannose-functionalized chitosan nanoparticles with intrinsic antibacterial properties against Gram-positive and Gram-negative bacteria and antibiofilm character [120]. Moreover, Kritchenkov et al developed betaine-type chitosan derivative nanoparticles through an ultrasound-assisted catalyst-free thiol-yne click chemistry with antibacterial activity [121]. Alternatively, there is an increasing interest in the use of essential oils as antibacterial agents in polymer-based drug delivery systems.…”

Section: Antibacterial Nanoparticlesmentioning

confidence: 99%

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

et al. 2021

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Despite the many advancements in the pharmaceutical and medical fields and the development of numerous antimicrobial drugs aimed to suppress and destroy pathogenic microorganisms, infectious diseases still represent a major health threat affecting millions of lives daily. In addition to the limitations of antimicrobial drugs associated with low transportation rate, water solubility, oral bioavailability and stability, inefficient drug targeting, considerable toxicity, and limited patient compliance, the major cause for their inefficiency is the antimicrobial resistance of microorganisms. In this context, the risk of a pre-antibiotic era is a real possibility. For this reason, the research focus has shifted toward the discovery and development of novel and alternative antimicrobial agents that could overcome the challenges associated with conventional drugs. Nanotechnology is a possible alternative, as there is significant evidence of the broad-spectrum antimicrobial activity of nanomaterials and nanoparticles in particular. Moreover, owing to their considerable advantages regarding their efficient cargo dissolving, entrapment, encapsulation, or surface attachment, the possibility of forming antimicrobial groups for specific targeting and destruction, biocompatibility and biodegradability, low toxicity, and synergistic therapy, polymeric nanoparticles have received considerable attention as potential antimicrobial drug delivery agents. In this context, the aim of this paper is to provide an up-to-date overview of the most recent studies investigating polymeric nanoparticles designed for antimicrobial therapies, describing both their targeting strategies and their effects.

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Ultrasound-assisted catalyst-free thiol-yne click reaction in chitosan chemistry: Antibacterial and transfection activity of novel cationic chitosan derivatives and their based nanoparticles

Cited by 32 publications

References 55 publications

Intranasal immunization with O-2′-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles loaded with Newcastle disease virus DNA vaccine enhances mucosal immune response in chickens

Intranasal immunization with O-2′-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles loaded with Newcastle disease virus DNA vaccine enhances mucosal immune response in chickens

Recent Advances in Antimicrobial Nano-Drug Delivery Systems

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

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