“…While ultrasonographic evaluation of vena cava diameter, distensibility, and collapsibility are increasingly used in emergency medicine and critical care, its use has numerous confounders (right heart dysfunction, obstructive cardiac physiology, transpulmonary and intraabdominal pressure, mode of ventilatory support) and is not currently supported by evidence in the perioperative setting (Millington, 2019;Via et al, 2016). Finally, it is important to note that fluid bolus therapy rapidly impacts the macrocirculation but does not necessarily alter the microcirculation or cellular function, especially during the short time frame used to assess fluid responsiveness.…”