Ultrasound and Probe Setting

Naro, Edoardo Di; Raio, Luigi; Basso, A.; Catalano, Mariana

doi:10.1007/978-3-030-28741-2_4

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Depending on the acoustic impedance changes between interfaces, the intensity of the produced echoes from the boundaries of structures and from the underlying texture will change. 9 However, while US imaging has a crucial role in assessing the extent of cancer lesions and cardiovascular pathologies, this technique cannot detect the diseases at early stages. In this regard, US imaging using nanoparticles (NPs) as contrast agents can provide early-stage diagnosis and improve imaging sensitivity and specificity.…”

Section: Introductionmentioning

confidence: 99%

Recent trends of contrast agents in ultrasound imaging: a review of the classifications and applications

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Recent trends of contrast agents in ultrasound imaging: a review of the classifications and applications

et al. 2022

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A Silk‐Based Functionalization Architecture for Single Fiber Imaging and Sensing

Capon

Horsfall

et al. 2021

Adv Funct Materials

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A new fiber functionalization architecture for single‐fiber imaging and sensing is presented. 5(6)Carboxy‐seminaphthorhodafluor‐2 (a fluorescent pH sensor) is attached to a silk‐binding peptide and the complex added to aqueous silk fibroin protein. These bind with a Kd of 36 µM as determined by a fluorescence polarization assay. The fiber is dip‐coated into the silk and peptide mixture, and scanning electron microscopy images reveal a uniform silk coating on the fiber tip. The coating is stable to repeated washes and does not affect the imaging light emitted from the fiber, which allows concurrent optical coherence tomography (OCT) imaging and pH sensing. Oocytes are metabolically stimulated with CoCl2 to produce lactic acid, and a pH reduction of 0.04 is measured using the probe. The distance between fiber tip and oocyte is monitored by simultaneous OCT acquisitions to precisely position the probe. Lastly, OCT imaging of an ovary revealed the presence/absence of an oocyte within a follicle, an important step toward improving patient outcomes during in vitro fertilization, by limiting the number of invasive follicle punctures required. These results demonstrate the utility of this new coating to enable simultaneous OCT imaging and sensing, which provides significant insight into complex biological systems.

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Ultrasound and Probe Setting

Cited by 2 publications

References 54 publications

Recent trends of contrast agents in ultrasound imaging: a review of the classifications and applications

Recent trends of contrast agents in ultrasound imaging: a review of the classifications and applications

A Silk‐Based Functionalization Architecture for Single Fiber Imaging and Sensing

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