Ultrasound and microbubble mediated therapeutic delivery: Underlying mechanisms and future outlook

Chowdhury, Sayan Mullick; Abou‐Elkacem, Lotfi; Lee, Taehwa; Dahl, Jeremy J.; Lutz, A.M.

doi:10.1016/j.jconrel.2020.06.008

Cited by 162 publications

(119 citation statements)

References 109 publications

Supporting

Mentioning

100

Contrasting

Order By: Relevance

“…This shows that countries leading in science and technology are exploring more of the uses of ultrasound. Improvements have emerged in ultrasonic technologies in developed countries, such as the invention of ultrasound and microbubble therapy (19), which can e ciently increase cell membrane permeability, resulting in enhanced tissue distribution and intracellular drug delivery of molecules, the popularity of small probes (20) and the combination of ultrasound, X-ray and MRI (21).…”

Section: Discussionmentioning

confidence: 99%

Bibliometric evaluation of ultrasound in orthopaedics global publications: 10-year trends and hotspots

Wang¹,

Xia²,

Zhang³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background. The past decade has witnessed the development of ultrasound in orthopaedics, the growth rate of publications has been accelerating. In this study, analysis of the publications on ultrasound in orthopaedics over the past decade has been completed. We aim to provide inspiration for future research on ultrasound in orthopaedics through our work.Methods. All relevant publications between 2009 and 2020 from Web of Science were collected. Statistical Package for Social Science and GraphPad Prism 8 software were used to generate and analyse diagrams. Meanwhile, from the aspects of co-occurring keywords, VOSviewer software and CiteSpace were employed to visualize the research trends.Results. 1,677 publications with a citation frequency of 20,311 were identified. The United States published most publications in this filed and the number of citations was also the highest, as well as the highest H-index. Although China ranked sixth in terms of the number of publications, the growth trend in the future will be fastest. Furthermore, Skeletal Radiology published the most papers related to ultrasound in orthopaedics, Ozcakar, L had published the most papers, and a study by Kwon, YM received the highest citation frequency. The keywords about "MRI", "complication", "female" and "male" were noted as new topics.Conclusions. Through the research, while the contributions of the publications from the United States were significant, the growth rate of Chinese publications in the future cannot be ignored. Moreover, it is hypothesized that diagnosis and epidemiology studies may become hotspots.

show abstract

Section: Discussionmentioning

confidence: 99%

Bibliometric evaluation of ultrasound in orthopaedics global publications: 10-year trends and hotspots

Wang¹,

Xia²,

Zhang³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Ultrasound technologies such as tumor ultrasound imaging and UMMD witnessed an increasing application in disease monitoring, diagnosis and treatment ( 19 ). US promotes pressure and temperature through cavitation, sonoporation, or thermal effects, which further enhances self-generated or exogenously introduced MB to rupture after expansion in the target area, resulting in changes in the permeability of tissues and cells ( 19 , 20 ). In the past, UMMD was often used to mechanically dissolve thrombus substances in cardiovascular diseases such as ischemia/reperfusion injury, myocardial infarction, and hypertension, in addition, as a carrier of drugs and nucleic acids, it is expected to become an adjuvant therapy for the treatment of patients with heart disease ( 21 , 22 ).…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-Mediated Microbubble Destruction Inhibits Skin Melanoma Growth by Affecting YAP1 Translation Using Ribosome Imprinting Sequencing

Wei

2021

Front. Oncol.

View full text Add to dashboard Cite

Cutaneous melanoma (CMM) is a skin tumor with a high degree of malignancy. BRAF resistance imposes great difficulty to the treatment of CMM, and partially contributes to the poor prognosis of CMM. YAP is involved in the growth and drug resistance of a variety of tumors, and mechanical signals may affect the activation of YAP1. As a novel ultrasound treatment technology, ultrasound-mediated microbubble destruction (UMMD) has been reported to have a killing effect on isolated CMM cells. In this study, the tumor tissue samples were collected from 64 CMM patients. We found that YAP1 mRNA expression was irrelevant to the clinicopathological characteristics and prognostic survival of the CMM patients. The drug-resistant cell line was constructed and subcutaneously implanted into nude mice, which were further separately treated with UMMD, ultrasound (US), and microbubbles (MB). The result showed that UMMD significantly inhibited the growth of tumor tissues. Ribosome imprinting sequencing (Ribo-seq) is a genetic technology for studying protein translation at genetic level. Ribo-seq, RNA-seq, and RT-qPCR were applied to detect YAP1 expression in CMM mouse tumor tissues. Ribo-seq data revealed that UMMD greatly up-regulated the expression of YAP1, interestingly, the up-regulated YAP1 was found to be negatively correlated with the weight of tumor tissues, while no significant change in YAP1 expression was detected by RNA-seq or RT-qPCR assay. These results indicated that UMMD could inhibit the tumor growth of drug-resistant CMM by affecting the translation efficiency of YAP1, providing a strong basis for the clinical treatment of UMMD in CMM.

show abstract

“…Several reports have shown that LIFU could enhance the drug sensitivity of some select chemotherapeutic drugs and could improve cell membrane permeability [ 33 – 35 ]. Our previous research showed that the combination of LIFU exposure and the nanobubble system can be used as an efficient and safe approach for gene delivery and transfection [ 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Single-cell RNA sequencing reveals the mechanism of sonodynamic therapy combined with a RAS inhibitor in the setting of hepatocellular carcinoma

Yuan

Liu

et al. 2021

J Nanobiotechnol

View full text Add to dashboard Cite

Background Ras activation is a frequent event in hepatocellular carcinoma (HCC). Combining a RAS inhibitor with traditional clinical therapeutics might be hampered by a variety of side effects, thus hindering further clinical translation. Herein, we report on integrating an IR820 nanocapsule-augmented sonodynamic therapy (SDT) with the RAS inhibitor farnesyl-thiosalicylic acid (FTS). Using cellular and tumor models, we demonstrate that combined nanocapsule-augmented SDT with FTS induces an anti-tumor effect, which not only inhibits tumor progression, and enables fluorescence imaging. To dissect the mechanism of a combined tumoricidal therapeutic strategy, we investigated the scRNA-seq transcriptional profiles of an HCC xenograft following treatment. Results Integrative single-cell analysis identified several clusters that defined many corresponding differentially expressed genes, which provided a global view of cellular heterogeneity in HCC after combined SDT/FTS treatment. We conclude that the combination treatment suppressed HCC, and did so by inhibiting endothelial cells and a modulated immunity. Moreover, hepatic stellate secretes hepatocyte growth factor, which plays a key role in treating SDT combined FTS. By contrast, enrichment analysis estimated the functional roles of differentially expressed genes. The Gene Ontology terms “cadherin binding” and “cell adhesion molecule binding” and KEGG pathway “pathway in cancer” were significantly enriched by differentially expressed genes after combined SDT/FTS therapy. Conclusions Thus, some undefined mechanisms were revealed by scRNA-seq analysis. This report provides a novel proof-of-concept for combinatorial HCC-targeted therapeutics that is based on a non-invasive anti-tumor therapeutic strategy and a RAS inhibitor.

show abstract

Ultrasound and microbubble mediated therapeutic delivery: Underlying mechanisms and future outlook

Cited by 162 publications

References 109 publications

Bibliometric evaluation of ultrasound in orthopaedics global publications: 10-year trends and hotspots

Bibliometric evaluation of ultrasound in orthopaedics global publications: 10-year trends and hotspots

Ultrasound-Mediated Microbubble Destruction Inhibits Skin Melanoma Growth by Affecting YAP1 Translation Using Ribosome Imprinting Sequencing

Single-cell RNA sequencing reveals the mechanism of sonodynamic therapy combined with a RAS inhibitor in the setting of hepatocellular carcinoma

Contact Info

Product

Resources

About

Ultrasound and microbubble mediated therapeutic delivery: Underlying mechanisms and future outlook

Cited by 162 publications

References 109 publications

Bibliometric evaluation of ultrasound in orthopaedics&nbsp;global publications: 10-year trends and&nbsp;hotspots

Bibliometric evaluation of ultrasound in orthopaedics&nbsp;global publications: 10-year trends and&nbsp;hotspots

Ultrasound-Mediated Microbubble Destruction Inhibits Skin Melanoma Growth by Affecting YAP1 Translation Using Ribosome Imprinting Sequencing

Single-cell RNA sequencing reveals the mechanism of sonodynamic therapy combined with a RAS inhibitor in the setting of hepatocellular carcinoma

Contact Info

Product

Resources

About

Bibliometric evaluation of ultrasound in orthopaedics global publications: 10-year trends and hotspots

Bibliometric evaluation of ultrasound in orthopaedics global publications: 10-year trends and hotspots