Ultrasound and magnetic resonance imaging assessment of joint disease in symptomatic patients with cystic fibrosis arthropathy

Fitch, G.; Williams, Kate; Freeston, Jane; Dass, Shouvik; Grainger, Andrew J.; Hodgson, Richard; Horton, Laura; Whitaker, Paul; Peckham, Daniel

doi:10.1016/j.jcf.2015.12.022

Cited by 8 publications

(10 citation statements)

References 18 publications

(18 reference statements)

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“…Anti‐CCP antibody measurement is relatively recent in clinical practice and therefore most published CFA studies do not report it. Measurement of anti‐CCP has been reported in only 15 CF patients, and was positive only in one …”

Section: Possible Pathogenesis Of Cfamentioning

confidence: 99%

“…Measurement of anti-CCP has been reported in only 15 CF patients and was positive only in 1. [19][20][21] In systemic lupus erythematosus, antibodies are made against double-stranded DNA (dsDNA). Genetic failure to clear antigenic material in the form of extracellular dsDNA is noted to cause a lupuslike disease including a vasculitic rash and joint inflammation.…”

Section: Possible Pathogenesis Of Cfamentioning

confidence: 99%

“…31 MRI and ultrasound use in CFA, however, has only been reported in one study, concluding that ultrasound may be the more feasible of the two to image the inflammation seen in CFA. 21 See Figure 2 for an example of the images seen using ultrasound in inflammatory arthritis. The evidence for the use of these increasingly available, noninvasive assessments must, therefore, be primarily extrapolated from their use in other rheumatic diseases.…”

Section: Investigations In Cfamentioning

confidence: 99%

“…Measurement of rheumatoid factor has been reported for 60 patients with CFA, with a positive result in 8; however, titres as low as 1/10 were recorded as positive . Of 15 anti‐CCP results reported, 1 was positive . Synovial fluid results were reported in two studies; clear paucicellular synovial fluid with negative microbial and crystal investigations were described in a total of six patients …”

mentioning

confidence: 99%

“…Sensitive imaging modalities such as magnetic resonance imaging and ultrasound are now more readily available to assess joint disease, with a proven ability to image inflammation in joints . MRI and ultrasound use in CFA, however, has only been reported in one study, concluding that ultrasound may be the more feasible of the two to image the inflammation seen in CFA . See Figure for an example of the images seen using ultrasound in inflammatory arthritis.…”

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confidence: 99%

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Assessing arthritis in the context of cystic fibrosis

Clarke

Watson

Freeston

et al. 2019

Pediatric Pulmonology

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Inflammatory arthritis in the context of cystic fibrosis (CF) can represent a diagnostic and therapeutic challenge. Poor recognition and under‐treatment of musculoskeletal conditions increases symptom burden, affects quality of life, and may lead to changes to an individual's ability to carry out activities of daily living and to exercise. A careful assessment and multidisciplinary approach is essential when considering a diagnosis of CF‐associated arthritis (CFA), both in terms of identifying other treatable conditions, such as rheumatoid arthritis, and effectively addressing symptoms. In this collaboration between CF specialists and Rheumatologists, we consider joint symptoms in patients with CF, with a focus on CFA. We offer a differential diagnosis list and consider steps to assess and manage CF patients presenting with arthralgia including appropriate up‐to‐date rheumatological assessment.

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Section: Possible Pathogenesis Of Cfamentioning

confidence: 99%

Section: Possible Pathogenesis Of Cfamentioning

confidence: 99%

Section: Investigations In Cfamentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Assessing arthritis in the context of cystic fibrosis

Clarke

Watson

Freeston

et al. 2019

Pediatric Pulmonology

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The burgeoning field of innate immune‐mediated disease and autoinflammation

Peckham

Scambler

Savic

et al. 2016

The Journal of Pathology

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Immune-mediated autoinflammatory diseases are occupying an increasingly prominent position among the pantheon of debilitating conditions that afflict humankind. This review focuses on some of the key developments that have occurred since the original description of autoinflammatory disease in 1999, and focuses on underlying mechanisms that trigger autoinflammation. The monogenic autoinflammatory disease range has expanded considerably during that time, and now includes a broad spectrum of disorders, including relatively common conditions such as cystic fibrosis and subsets of systemic lupus erythematosus. The innate immune system also plays a key role in the pathogenesis of complex inflammatory disorders. We have proposed a new nomenclature to accommodate the rapidly increasing number of monogenic disorders, which predispose to either autoinflammation or autoimmunity or, indeed, combinations of both. This new terminology also encompasses a wide spectrum of genetically determined autoinflammatory diseases, with variable clinical manifestations of immunodeficiency and immune dysregulation/autoimmunity. We also explore some of the ramifications of the breakthrough discovery of the physiological role of pyrin and the search for identifiable factors that may serve to trigger attacks of autoinflammation. The evidence that pyrin, as part of the pyrin inflammasome, acts as a sensor of different inactivating bacterial modification Rho GTPases, rather than interacting directly with these microbial products, sets the stage for a better understanding of the role of microorganisms and infections in the autoinflammatory disorders. Finally, we discuss some of the triggers of autoinflammation as well as potential therapeutic interventions aimed at enhancing autophagy and proteasome degradation pathways.

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Rheumatologic Manifestations of CF

Reis

White

2020

Respiratory Medicine

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Ultrasound and magnetic resonance imaging assessment of joint disease in symptomatic patients with cystic fibrosis arthropathy

Cited by 8 publications

References 18 publications

Assessing arthritis in the context of cystic fibrosis

Assessing arthritis in the context of cystic fibrosis

The burgeoning field of innate immune‐mediated disease and autoinflammation

Rheumatologic Manifestations of CF

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