Ultrasound and Bioptic Investigation of Patients with Primary Sjögren’s Syndrome

Manfrè, Valeria; Giovannini, Ivan; Callegher, Sara Zandonella; Lorenzon, Michele; Pegolo, Enrico; Tel, Alessandro; Gandolfo, Saviana; Quartuccio, Luca; Vita, Salvatore De; Zabotti, Alen

doi:10.3390/jcm10061171

Cited by 12 publications

(14 citation statements)

References 89 publications

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“…An open surgical biopsy of the parotid gland is the recommended procedure in case of SG enlargement;19 20 however, the need of a skilled surgeon and the risk of potential complications limit its generalisability 20 21. Recently, ultrasound (US)-guided core needle biopsy (US-guided CNB) has been proposed as a diagnostic procedure for patients with pSS with suspected glandular lymphoma 17 22. However, evidence of this procedure’s safety, patient tolerance and standardisation remains limited 23.…”

Section: Introductionmentioning

confidence: 99%

Safety, patient acceptance and diagnostic accuracy of ultrasound core needle biopsy of parotid or submandibular glands in primary Sjögren’s syndrome with suspected salivary gland lymphoma

et al. 2022

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BackgroundEnlargement of the major salivary glands (SGs) is a major risk factor for B-cell lymphoma among patients with primary Sjögren’s syndrome (pSS). Ultrasound-guided core needle biopsy (US-guided CNB) could be a novel technique to manage SG enlargement among patients with pSS.ObjectiveAccordingly, this study’s main aim was to evaluate the safety, patient tolerance and diagnostic accuracy of US-guided CNB procedure for patients with pSS with major SG enlargement.MethodsPatients with clinical diagnosis of pSS and a clinical indication for SG biopsy consecutively underwent US-guided CNB between September 2019 and June 2021. These patients were evaluated clinically 1, 2 and 12 weeks after US-guided CNB. Patients were asked to complete a questionnaire about postprocedural complications as well as periprocedural pain, using the Visual Analogue Scale. Complications were categorised as transient (<12 weeks) or persistent (≥12 weeks).ResultsUS-guided CNB was performed on 30 major salivary glands (22 parotid glands and 8 submandibular glands). The procedure was well tolerated. Transient complications—such as haematoma, swelling—were observed among 43% of patients, and mean periprocedural pain was low. However, no persistent complications were reported during the study’s follow-up period.ConclusionUS-guided CNB represents a novel approach for the management of patients with pSS with SG enlargement. The procedure showed remarkable patient safety and tolerance, allowing adequate glandular sampling and a definite diagnosis for almost all participating patients without long-term complications.

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Section: Introductionmentioning

confidence: 99%

Safety, patient acceptance and diagnostic accuracy of ultrasound core needle biopsy of parotid or submandibular glands in primary Sjögren’s syndrome with suspected salivary gland lymphoma

et al. 2022

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“…In mice with an autoimmune background, lymphadenopathy occurs at 6 months, and B cells undergo monoclonal expansion, giving rise to lymphoma, by the age of 1 year 41 . Clinically, the presence of lymphadenopathy predicts future lymphoma risk, 42 and transcriptomic analysis has revealed CREM as a top upstream transcriptional regulator of molecular signatures associated with lymphomagenic transdifferentiation 43 . Furthermore, methotrexate and biologics reduce CREM expression (Figure 2A,F), and several cohort studies have reported protective effects of methotrexate and biologics on lymphoma 44,45 …”

Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic alterations of cyclic AMP response element modulator in rheumatoid arthritis

Tseng

Lin

et al. 2022

Eur J Clin Investigation

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Background: Genetic and epigenetic factors are strongly associated with the autoimmune disease rheumatoid arthritis (RA). Cyclic AMP response element modulator (CREM), a gene related to immune system regulation, has been implicated in various immune-mediated inflammatory processes, although it remains unknown whether CREM is involved in RA.Methods: This study enrolled 278 RA patients and 262 controls. Three variants [rs12765063, rs17499247, rs1213386] were identified through linkage disequilibrium and expression quantitative trait locus analysis, and CREM transcript abundance was determined by quantitative real-time polymerase chain reaction.The identified variants were genotyped using the TaqMan Allelic Discrimination assay, and CREM promoter methylation was assessed by bisulphite sequencing.Differences between groups and correlations between variables were assessed with Student's t-tests and Pearson's correlation coefficients. Associations between phenotypes and genotypes were evaluated with logistic regression.Results: Rheumatoid arthritis patients exhibited increased CREM expression (p < .0001), which was decreased by methotrexate (p = .0223) and biologics (p = .0001), but could not be attributed to CREM variants. Interestingly, rs17499247 displayed a significant association with serositis (p = .0377), and rs1213386 increased the risk of lymphadenopathy (p = .0398). Furthermore, seven CpG sites showed decreased methylation in RA (p = .0477~ p < .0001).

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“…Die sonografischen Veränderungen der Speicheldrüsen haben dank der charakteristischen Darstellung mittlerweile einen hohen Stellenwert bei Diagnosestellung und Verlaufsbeurteilung von Autoimmunopathien wie dem Morbus Sjögren erlangt [33].…”

Section: Merkeunclassified

Sonografische Diagnostik im Kopf-Hals-Bereich – Teil 2: Transzervikale Sonografie

Weimer¹,

Rink²,

Müller³

et al. 2022

Laryngorhinootologie

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Die transzervikale Sonografie ist aus der Diagnostik der Hals-Nasen-Ohren-Heilkunde nicht mehr wegzudenken. Darum sollte der Anwender bzw. die Anwenderin ein Grundverständnis der Ultraschallphysik und technischer Innovationen haben. In diesem Fortbildungsartikel spannen die Autoren den Bogen von der Einführung in die strukturierte Untersuchungstechnik bis hin zu einem klinischen Update zur Sonografie von Kopfspeicheldrüsen und Halslymphknoten.

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Ultrasound and Bioptic Investigation of Patients with Primary Sjögren’s Syndrome

Cited by 12 publications

References 89 publications

Safety, patient acceptance and diagnostic accuracy of ultrasound core needle biopsy of parotid or submandibular glands in primary Sjögren’s syndrome with suspected salivary gland lymphoma

Safety, patient acceptance and diagnostic accuracy of ultrasound core needle biopsy of parotid or submandibular glands in primary Sjögren’s syndrome with suspected salivary gland lymphoma

Genetic and epigenetic alterations of cyclic AMP response element modulator in rheumatoid arthritis

Sonografische Diagnostik im Kopf-Hals-Bereich – Teil 2: Transzervikale Sonografie

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