Ultrasound activation of liposomes for enhanced ultrasound imaging and synergistic gas and sonodynamic cancer therapy

Lin, Xiahui; Qiu, Yuan; Liu, Song; Chen, Shan; Chen, Xiaofeng; Huang, Guoming; Song, Jibin; Chen, Xiaoyuan; Yang, Huanghao

doi:10.1039/c8nh00340h

Cited by 99 publications

(78 citation statements)

References 56 publications

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“…[27c,97] To overcome the above-mentioned negative problems, various strategies for O 2 supply to achieve hypoxia oxygenation and enhance the therapeutic effect of SDT have emerged. For example, Chen et al successfully developed a fluorocarbon (FC)-mediated O 2 direct delivery protocol by modifying FC to hollow a mesoporous [90] Copyright 2019, Royal Society of Chemistry. organosilica carrier.…”

Section: Sonodynamic Therapy Combined With Chemodynamic Therapymentioning

confidence: 99%

“…developed a 2,2′‐azobis[2‐(2‐imidazolin‐2‐yl)propane] dihydrochloride (AIPH)‐loaded liposome for enhanced US imaging and synergistic gas therapy and SDT ( Figure A). [ 90 ] Upon US irradiation, the loaded AIPH was demonstrated to be efficiently decomposed to produce N 2 and ROS without dependence on O 2 concentration. The cytotoxicity of the produced ROS was evaluated on MCF‐7 cells using the calcein‐AM/PI double staining technique (Figure 12B).…”

Section: Sonodynamic Therapy Combined With Other Treatmentsmentioning

confidence: 99%

“…developed the AIPH‐loaded liposome to generate N 2 bubbles and alkyl radicals triggered by low‐intensity ultrasonic waves for concurrent US imaging and therapy. [ 90 ] In another study, Ce6‐encapsulated calcium carbonate (CaCO 3 ) nanoparticles were fabricated for US imaging‐guided PDT. [ 144 ] When these nanoparticles were accumulated into the tumor tissue, the acidic tumor microenvironment triggered the decomposition of CaCO 3 for the production of CO 2 bubbles, which acted as the US contrast agents in US imaging.…”

Section: Other Biomedical Applications Of Ultrasoundmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial-assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better-quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

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Section: Sonodynamic Therapy Combined With Chemodynamic Therapymentioning

confidence: 99%

Section: Sonodynamic Therapy Combined With Other Treatmentsmentioning

confidence: 99%

Section: Other Biomedical Applications Of Ultrasoundmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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“…The introduction of nanotechnology has provided a new way of delivering sonosensitizers and shown unique advantages in the field of cancer therapy. Compared to organic compounds, inorganic nanomaterials have the following advantages: (1) controllable of particle size and morphology, (2) excellent chemical and physiological stability, and (3) high tumor targeting efficacy [54][55][56][57][58]. In this review, we summarize the recently progress in nanomaterials for SDT application.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in nanomaterials for sonodynamic therapy

Zhao

Lin

et al. 2020

Nano Res.

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Sonodynamic therapy (SDT), as a novel non-invasive strategy for eliminating tumor, has the advantages of deeper tissue penetration, fewer side effects, and better patient compliance, compared with photodynamic therapy (PDT). In SDT, ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species (ROS), induce the collapse of vacuoles in solution, and bring about irreversible damage to cancer cells. In recent years, much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ROS. However, the traditional organic sonosensitizers, such as porphyrins, hypericin, and curcumins, suffer from complex synthesis, poor water solubility, and low tumor targeting efficacy which limit the benefits of SDT. In contrast, inorganic sonosensitizers show good in vivo stability, controllable physicochemical properties, ease of achieving multifunctionality, and high tumor targeting, which greatly expanded their application in SDT. In this review, we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers, and directly produce ROS under ultrasound. Moreover, the prospects of inorganic nanomaterials for SDT application are also discussed.

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A Novel Pt–TiO₂ Heterostructure with Oxygen‐Deficient Layer as Bilaterally Enhanced Sonosensitizer for Synergistic Chemo‐Sonodynamic Cancer Therapy

Liang

Deng

et al. 2020

Adv Funct Materials

244

194

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Sonodynamic therapy (SDT) activated by ultrasound is attractive as a potential alternative to conventional phototriggered therapies owing to the deeper penetration depth and the absence of phototoxicity. Nevertheless, the low quantum yield of nano‐sonosensitizer and the tumor hypoxia remain significant challenges for SDT. Herein, a novel TiO2‐based nano‐sonosensitizer is reported to bilaterally enhance the quantum yield by simultaneous integration of precious metal Pt nanoparticles (NPs) and an oxygen‐deficient layer. Furthermore, the hollow cavity of TiO2 serves as a reservoir to load doxorubicin, an anticancer drug for chemotherapy as well as a molecular sonosensitizer for SDT. The decorated Pt NPs act as nanozymes to catalyze the decomposition of endogenous hydrogen peroxide for the generation of oxygen to alleviate tumor hypoxia, reduce resistance to chemotherapy, and provide sufficient oxygen source for subsequently facilitating SDT‐induced reactive oxygen species production. The high chemo‐sonodynamic synergistic efficacy is systematically demonstrated both in vitro and in vivo. More importantly, it is believed that the novel design and the new finding in the synthesis of Pt–TiO2 heterostructures can be popularized for the preparation and application of the semiconductor‐based nanoplatforms in many fields.

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Ultrasound activation of liposomes for enhanced ultrasound imaging and synergistic gas and sonodynamic cancer therapy

Abstract: Ultrasound (US) imaging is widely applied in hospital and clinical settings due to its non-invasiveness, controllability, and high tissue-penetrating ability.

Cited by 99 publications

References 56 publications

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Recent advances in nanomaterials for sonodynamic therapy

A Novel Pt–TiO₂ Heterostructure with Oxygen‐Deficient Layer as Bilaterally Enhanced Sonosensitizer for Synergistic Chemo‐Sonodynamic Cancer Therapy

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Ultrasound activation of liposomes for enhanced ultrasound imaging and synergistic gas and sonodynamic cancer therapy

Abstract: Ultrasound (US) imaging is widely applied in hospital and clinical settings due to its non-invasiveness, controllability, and high tissue-penetrating ability.

Cited by 99 publications

References 56 publications

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Recent advances in nanomaterials for sonodynamic therapy

A Novel Pt–TiO2 Heterostructure with Oxygen‐Deficient Layer as Bilaterally Enhanced Sonosensitizer for Synergistic Chemo‐Sonodynamic Cancer Therapy

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A Novel Pt–TiO₂ Heterostructure with Oxygen‐Deficient Layer as Bilaterally Enhanced Sonosensitizer for Synergistic Chemo‐Sonodynamic Cancer Therapy