Ultrasound Activates the TM ELAM-1/IL-1/NF-κB Response: A Potential Mechanism for Intraocular Pressure Reduction after Phacoemulsification

Wang, Nan; Chintala, Shravan K.; Fini, M. Elizabeth; Schuman, Joel S.

doi:10.1167/iovs.02-0631

Cited by 111 publications

(70 citation statements)

References 23 publications

(24 reference statements)

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“…Trabecular endothelial remodeling in response to ultrasonic stress, 27 prostaglandin release, 28 and increase in aqueous outflow by expansion of the trabecular meshwork 4 are some of the hypothetical mechanisms, but angle and ACD change induced by cataract removal has been shown to be the main mechanism of IOP change in OAs as well as NAs. 14 Huang et al 9 supported this hypothesis by showing that IOP reduction was associated with angle widening in both OA and NA eyes.…”

Section: Discussionmentioning

confidence: 99%

Lens parameters as predictors of intraocular pressure changes after phacoemulsification

Moghimi

Abdi

Latifi

et al. 2015

Eye

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Purpose To evaluate intraocular pressure (IOP) change after cataract surgery in nonglaucomatous eyes with narrow and open angles (OAs) and its relation to novel lens parameters measured by anterior segment optical coherence tomography (AS-OCT). Setting University affiliated hospital, Farabi Eye Hospital, Tehran, Iran. Design Prospective interventional case series. Methods In this prospective study, 85 nonglaucomatous eyes underwent phacoemulsification and lens implantation. Thirty-nine eyes had OAs and 46 eyes had narrow angles (NAs). IOP and biometric parameters were measured by AS-OCT preoperatively and 3 months after surgery. Change in IOP and its relation to biometric parameters, including lens vault (LV), anterior vault (AV), defined as the sum of the LV and the ACD, and relative LV (rLV), defined as the ratio of the LV to the AV, were evaluated. The main outcome measure was degree of IOP change after phacoemulsification. Results Of the 85 patients included in the analysis, 35 were male and 50 were female with an overall mean age of 62.2 ± 8.9 years. The average IOP reduction was − 4.95 ± 2.26 mm Hg, from a preoperative mean of 17.12 ± 2.47 mm Hg, at 3 months after cataract surgery. The amount of IOP reduction was significantly greater in the NA compared with the OA group. In multivariate linear regression analysis, preoperative IOP and AV were significantly associated with IOP decrease (all ≤ 0.03). Conclusion Cataract surgery results in IOP reduction in both OA and NA eyes. The amount of IOP reduction is related to AV.

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Section: Discussionmentioning

confidence: 99%

Lens parameters as predictors of intraocular pressure changes after phacoemulsification

Moghimi

Abdi

Latifi

et al. 2015

Eye

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“…5,6 In addition, in cultured trabecular meshwork (TM) cells, phacoemulsification ultrasound upregulates interleukin IL-1a and endothelial leukocyte adhesion molecule-1, 7 suggesting potential effects of IL-1a on IOP reduction after phacoemulsification. On the other hand, our previous study showed that aqueous humor obtained from eyes with open-angle glaucoma contained increased monocyte chemoattractant protein-1 (MCP-1)/CC chemokine ligand 2 and IL-8 levels after phacoemulsification.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 on Aqueous Humor Outflow Facility

Tsuboi

Inoue

Kawai

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To investigate the effect of monocyte chemoattractant protein-1 (MCP-1)/CC chemokine ligand 2 on aqueous humor outflow facility.METHODS. Aqueous humor outflow facility was measured in enucleated porcine eyes in a constant pressure perfusion system with or without MCP-1 (1600 ng/mL). Expression of CCR2, an MCP-1 receptor, in Schlemm's canal endothelial (SCE) cells was examined by reverse transcription-polymerase chain reaction (RT-PCR) assay. The effect of MCP-1 (0-1600 ng/ mL) on SCE cell viability was evaluated using a WST-8 assay.The effect of MCP-1 (0-800 ng/mL) on SCE-cell monolayer permeability was evaluated with or without a CCR2 antagonist (10 nM) by measuring transendothelial electrical resistance (TEER). The intracellular localization of the gap junction protein ZO-1 was analyzed by immunofluorescence staining of SCE cells. RESULTS.The aqueous humor outflow facility increased significantly from basal levels at 80 minutes after perfusion with MCP-1 compared with control eyes (21.2% 6 6.6% [MCP-1] vs. 5.7 6 2.5% [control]; P ¼ 0.048). CCR2 was detected by RT-PCR. Cell viability was not affected by MCP-1 treatment. TEER of SCE-cell monolayer at 3 hours after treatment with 800 ng/mL MCP-1 decreased by 21.6 6 1.7% compared with controls (P ¼ 0.014), and the TEER-decreasing effects of MCP-1 were attenuated by a CCR2 antagonist. Immunocytochemical staining revealed a modest disruption of ZO-1 in MCP-1-treated SCE cells. CONCLUSIONS.The present results revealed that MCP-1 increased aqueous humor outflow facility and decreased TEER via CCR2. These findings suggest that MCP-1 modulates aqueous humor outflow through the conventional pathway. (Invest Ophthalmol Vis Sci. 2012;53:6702-6707) DOI:10.1167/iovs.12-10376 C ataract surgery affects postoperative intraocular pressure (IOP). Although phacoemulsification has become the standard choice for surgical treatment of cataracts using minimally invasive procedures, the effects on IOP reduction after classical large incision cataract surgery are clinically similar.1 The reduction in IOP after cataract surgery is positively related to preoperative IOP, and inversely related to preoperative anterior chamber depth.2,3 Interestingly, IOP after phacoemulsification is decreased more in glaucomatous eyes compared with non-glaucomatous eyes, and remains reduced for a long period. 4 The exact mechanisms related to the IOP-reducing effects of phacoemulsification, however, are not yet thoroughly understood.Interleukin (IL)-1a increases outflow facility. 5,6 In addition, in cultured trabecular meshwork (TM) cells, phacoemulsification ultrasound upregulates interleukin IL-1a and endothelial leukocyte adhesion molecule-1, 7 suggesting potential effects of IL-1a on IOP reduction after phacoemulsification. On the other hand, our previous study showed that aqueous humor obtained from eyes with open-angle glaucoma contained increased monocyte chemoattractant protein-1 (MCP-1)/CC chemokine ligand 2 and IL-8 levels after phacoemulsification. 8 In another study, we also observed el...

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“…Poley et al suggest that lens removal allows the posterior capsule to move posteriorly, dislodging the zonula over the ciliary body with a consequent widening of Schlemm's canal and aqueous humour drainage improvement [12]. Another theory suggests that ultrasound energy used for phacoemulsification procedure is responsible for a sudden rise of pressure in the anterior chamber, producing inflammatory cytokines (mostly IL-1) that stimulate metalloproteinase production and trabecular meshwork remodelling, facilitating humour drainage [13].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of efficacy of lens extraction for intraocular pressure reduction in eyes with primary angle closure glaucoma and primary angle closure

2017

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introduCtion. The purpose of the study was to evaluate the intraocular pressure (IOP) lowering effect of lens removal in eyes with primary angle closure glaucoma (PACG) and primary angle closure (PAC). MATERIALS AND METHODS. This study was a retrospective analysis of 114 eyes of 97 patients (83 women, 14 men; mean age 69.9 years) with PACG and PAC treated with lens extraction. Outcome measures: age, gender, visual acuity, IOP reduction over time, preoperative and postoperative number of IOP-lowering medications, axial length, intraocular lens (IOL) power, requirement for additional anti-glaucoma operations, and complications. Patients were divided into three groups: 1) patients with PAC (22 eyes) with mean follow-up 12.2 months; 2) patients with PACG with a history of previous acute angle closure (AAC) (39 eyes) with mean follow-up 15.4 months; and 3) patients with PACG without a history of previous AAC (53 eyes), with mean follow-up 13.5 months. Laser iridotomy was performed in all treated eyes prior to the surgery. RESULTS. In the group with PAC mean IOP was reduced from 42.2 ± 15.4 mm Hg (mean ± SD) under 2.6 IOP-lowering medications to 20.2 ± 10.4 mm Hg under 1.1 IOP-lowering medications (mean IOP reduction 52.1%). In the group with PACG with a history of previous AAC mean IOP was reduced from 29.0 ± 15.7 mm Hg under 2.1 IOP-lowering medications to 17.0 ± 7.5 mm Hg under 0.7 IOP-lowering medications (mean IOP reduction 41.3%). In the group with PACG without a history of previous AAC (53 eyes) mean IOP was reduced from 22.8 ± 8.0 mm Hg under 1.75 IOP-lowering medications to 18.8 ± 7.4 mm Hg under 1.5 IOP-lowering medications (mean IOP reduction 17.5%). In all three groups statistically significant improvement of visual acuity as a result of surgery was observed. There were no statistically significant differences between the three groups with regard to AXL or IOL power. Intraoperative complications were noticed in eight cases, and postoperative complications were noticed in four cases. The number of anti-glaucoma medications was reduced, but 17 eyes needed additional anti-glaucoma procedures. CONCLUSIONS. Lens extraction in eyes with PACG and PAC resulted in significant IOP reduction in all groups. The most pronounced IOP reduction was achieved in the group with PAC, where lens extraction was performed up to 60 days from AAC. Visual acuity was significantly improved as a result of surgery in all three study groups.

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Ultrasound Activates the TM ELAM-1/IL-1/NF-κB Response: A Potential Mechanism for Intraocular Pressure Reduction after Phacoemulsification

Cited by 111 publications

References 23 publications

Lens parameters as predictors of intraocular pressure changes after phacoemulsification

Lens parameters as predictors of intraocular pressure changes after phacoemulsification

The Effect of Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 on Aqueous Humor Outflow Facility

Evaluation of efficacy of lens extraction for intraocular pressure reduction in eyes with primary angle closure glaucoma and primary angle closure

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