Ultrasound-activable piezoelectric membranes for accelerating wound healing

Abstract

Piezoelectric membranes activated by ultrasound waves can provide electrical stimulation to promote wound healing.

Advances in applications of piezoelectronic electrons in cell regulation and tissue regeneration

“…Proliferation and migration of the fibroblasts were reported to improve by ultrasonic stimulation on P(VDF-TrFE)/BT membranes. 178 In an animal wound model, the wound closure rate was faster when stimulated by EF generated from the membranes. In another work, to accelerate chronic wound healing, a flexible ultrasonic patch was designed and fabricated.…”

Electroactive nanofibrous membrane with temperature monitoring for wound healing

“…Endogenous electric field, which could promote cell proliferation and migration, is crucial to skin regenerative activities and wound repair. 5,6 Recently, various electroactive wound dressings have been developed, including conductive nanofibers, 7,8 conductive hydrogels, 9,10 piezoelectric patches, 11,12 and micro-battery dressings. 13,14 Among them, the micro-battery dressings impregnate electrochemically coupled metals on the fabric, and electric stimulation (ES) is generated when a conductive medium (wound's exudate, blood, etc. )…”

Layer-by-Layer Microneedle-Mediated rhEGF Transdermal Delivery for Enhanced Wound Epidermal Regeneration and Angiogenesis

“…At present, the common clinical methods to solve the problem of wound closure and healing mainly rely on traditional wound dressings (such as gauze, external cream, and different sorts of film or gel-based patches), which cannot only delay the wound closure but also aggravate patients’ negative emotions such as anxiety or depression and reduce their compliance in primary disease treatment, especially for refractory wounds . Up to now, while therapeutic modalities such as electrical stimulation, hyperbaric oxygen, negative pressure, ultrasonic, and photo-assistance have been developed, − professional technicians for supplying complicated operations and expensive large-sized equipment for providing appropriate medical fields are often required, and patients even need to be hospitalized in most cases, seriously limiting the clinical application. Currently, great endeavors have been dedicated to pushing forward the development of wound dressings, and a series of emerging stimuli-responsive hydrogels have been employed for the release of bioactive drug molecules to heal wounds, in which of process external interventions (e.g., temperature, mechano, light, and syringes) are involved. − Nevertheless, this will complicate the manufacturing process and make the cargo activity easy to lose, and meanwhile, cause some non-negligible adverse reactions such as tanning, burning, soreness, and allergic inflammation to the damaged part and the just healing wound.…”