“…At present, the common clinical methods to solve the problem of wound closure and healing mainly rely on traditional wound dressings (such as gauze, external cream, and different sorts of film or gel-based patches), which cannot only delay the wound closure but also aggravate patientsâ negative emotions such as anxiety or depression and reduce their compliance in primary disease treatment, especially for refractory wounds . Up to now, while therapeutic modalities such as electrical stimulation, hyperbaric oxygen, negative pressure, ultrasonic, and photo-assistance have been developed, â professional technicians for supplying complicated operations and expensive large-sized equipment for providing appropriate medical fields are often required, and patients even need to be hospitalized in most cases, seriously limiting the clinical application. Currently, great endeavors have been dedicated to pushing forward the development of wound dressings, and a series of emerging stimuli-responsive hydrogels have been employed for the release of bioactive drug molecules to heal wounds, in which of process external interventions (e.g., temperature, mechano, light, and syringes) are involved. â Nevertheless, this will complicate the manufacturing process and make the cargo activity easy to lose, and meanwhile, cause some non-negligible adverse reactions such as tanning, burning, soreness, and allergic inflammation to the damaged part and the just healing wound.…”