Ultrasound: A potential technique to improve osseointegration of dental implants

Li, Lei; Zhu, Zhi‐Biao; Huang, Chunpeng; Chen, Wenchuan

doi:10.1016/j.mehy.2008.05.013

Cited by 14 publications

(5 citation statements)

References 29 publications

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“…By using the treatment of LIPUS, the rehabilitation time may be shortened due to the acceleration of bone tissue regeneration. At the same time, the osseointegration can be strengthened, and a higher survival rate of the implants will ensue [47]. This indicated that optimal LIPUS device or stimulator with the proper intensity, duty cycle, and time could enhance the in vitro growth and osteogenic differentiation of dental stem cells for tooth tissue engineering.…”

Section: Discussionmentioning

confidence: 99%

In VitroEffects of Low-Intensity Pulsed Ultrasound Stimulation on the Osteogenic Differentiation of Human Alveolar Bone-Derived Mesenchymal Stem Cells for Tooth Tissue Engineering

Lim

Kim

Seonwoo

et al. 2013

BioMed Research International

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Ultrasound stimulation produces significant multifunctional effects that are directly relevant to alveolar bone formation, which is necessary for periodontal healing and regeneration. We focused to find out effects of specific duty cycles and the percentage of time that ultrasound is being generated over one on/off pulse period, under ultrasound stimulation. Low-intensity pulsed ultrasound ((LIPUS) 1 MHz) with duty cycles of 20% and 50% was used in this study, and human alveolar bone-derived mesenchymal stem cells (hABMSCs) were treated with an intensity of 50 mW/cm2 and exposure time of 10 min/day. hABMSCs exposed at duty cycles of 20% and 50% had similar cell viability (O.D.), which was higher (*P < 0.05) than that of control cells. The alkaline phosphatase (ALP) was significantly enhanced at 1 week with LIPUS treatment in osteogenic cultures as compared to control. Gene expressions showed significantly higher expression levels of CD29, CD44, COL1, and OCN in the hABMSCs under LIPUS treatment when compared to control after two weeks of treatment. The effects were partially controlled by LIPUS treatment, indicating that modulation of osteogenesis in hABMSCs was related to the specific stimulation. Furthermore, mineralized nodule formation was markedly increased after LIPUS treatment than that seen in untreated cells. Through simple staining methods such as Alizarin red and von Kossa staining, calcium deposits generated their highest levels at about 3 weeks. These results suggest that LIPUS could enhance the cell viability and osteogenic differentiation of hABMSCs, and could be part of effective treatment methods for clinical applications.

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Section: Discussionmentioning

confidence: 99%

In VitroEffects of Low-Intensity Pulsed Ultrasound Stimulation on the Osteogenic Differentiation of Human Alveolar Bone-Derived Mesenchymal Stem Cells for Tooth Tissue Engineering

Lim

Kim

Seonwoo

et al. 2013

BioMed Research International

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“…In addition to pharmacological interventions, mechanical stimuli represent an alternative therapeutic approach for mitigating bone loss by promoting bone growth. LIPUS, as a type of mechanical stimulus, has significant advantages for osteogenesis by promoting the differentiation of osteoblasts, thereby effectively facilitating bone regeneration [ 240 ]. In 1994, LIPUS was approved as an adjuvant therapy in the healing of primary fractures [ 241 ].…”

Section: Perspectives and Conclusionmentioning

confidence: 99%

The Mechanotransduction Signaling Pathways in the Regulation of Osteogenesis

Liu,

Wang,

Zhang

et al. 2023

IJMS

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Bones are constantly exposed to mechanical forces from both muscles and Earth’s gravity to maintain bone homeostasis by stimulating bone formation. Mechanotransduction transforms external mechanical signals such as force, fluid flow shear, and gravity into intracellular responses to achieve force adaptation. However, the underlying molecular mechanisms on the conversion from mechanical signals into bone formation has not been completely defined yet. In the present review, we provide a comprehensive and systematic description of the mechanotransduction signaling pathways induced by mechanical stimuli during osteogenesis and address the different layers of interconnections between different signaling pathways. Further exploration of mechanotransduction would benefit patients with osteoporosis, including the aging population and postmenopausal women.

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“…Because ultrasound is a mechanical wave, quantitative ultrasound (QUS) techniques are naturally likely to retrieve bone mechanical properties. Another advantage of QUS techniques lies in that ultrasound is non-invasive (ultrasound is even used to stimulate osseointegration [142]), non-radiative and relatively cheap. Note that, in the context of osteoporosis assessment, QUS is now routinely used clinically to assess bone fragility [143].…”

Section: Quantitative Ultrasoundmentioning

confidence: 99%

Biomechanical behaviours of the bone–implant interface: a review

Gao

Fraulob

Haïat

2019

J. R. Soc. Interface.

163

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In recent decades, cementless implants have been widely used in clinical practice to replace missing organs, to replace damaged or missing bone tissue or to restore joint functionality. However, there remain risks of failure which may have dramatic consequences. The success of an implant depends on its stability, which is determined by the biomechanical properties of the bone–implant interface (BII). The aim of this review article is to provide more insight on the current state of the art concerning the evolution of the biomechanical properties of the BII as a function of the implant's environment. The main characteristics of the BII and the determinants of implant stability are first introduced. Then, the different mechanical methods that have been employed to derive the macroscopic properties of the BII will be described. The experimental multi-modality approaches used to determine the microscopic biomechanical properties of periprosthetic newly formed bone tissue are also reviewed. Eventually, the influence of the implant's properties, in terms of both surface properties and biomaterials, is investigated. A better understanding of the phenomena occurring at the BII will lead to (i) medical devices that help surgeons to determine an implant's stability and (ii) an improvement in the quality of implants.

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Ultrasound: A potential technique to improve osseointegration of dental implants

Cited by 14 publications

References 29 publications

In VitroEffects of Low-Intensity Pulsed Ultrasound Stimulation on the Osteogenic Differentiation of Human Alveolar Bone-Derived Mesenchymal Stem Cells for Tooth Tissue Engineering

In VitroEffects of Low-Intensity Pulsed Ultrasound Stimulation on the Osteogenic Differentiation of Human Alveolar Bone-Derived Mesenchymal Stem Cells for Tooth Tissue Engineering

The Mechanotransduction Signaling Pathways in the Regulation of Osteogenesis

Biomechanical behaviours of the bone–implant interface: a review

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