Ultrasonography used in the diagnosis of chronic rhinosinusitis: From experimental imaging to clinical practice

Neagoş, Adriana; Dumitru, Mihai; Vrînceanu, Daniela; Costache, Adrian; Marinescu, A; Cergan, Romică

doi:10.3892/etm.2021.10043

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…In the hands of the experienced investigator, it may serve as a complementary radiation-free screening procedure for acute complications of PNS [ 29 ] or in cases of mid-face trauma [ 30 ]. In conclusion, our data show a high degree of comparability with other recent studies [ 31 , 32 ]. The fast availability and the possibility of direct correlation with endoscopy make ultrasound a promising complementary diagnostic tool in the context of CRS.…”

Section: Discussionsupporting

confidence: 90%

Multicenter Observational Study to Evaluate the Diagnostic Value of Sonography in Patients with Chronic Rhinosinusitis

et al. 2022

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(1) Background: Computed tomography (CT) is considered mandatory for assessing the extent of pathologies in the paranasal sinuses (PNS) in chronic rhinosinusitis (CRS). However, there are few evidence-based data on the value of ultrasound (US) in CRS. This multicenter approach aimed to compare diagnostic imaging modalities in relation to findings during surgery. (2) Methods: 127 patients with CRS were included in this prospective multicenter study. Patients received preoperative US and CT scans. The sensitivity and specificity of CT and US were extrapolated from intraoperative data. (3) Results: CT scans showed the highest sensitivity (97%) and specificity (67%) in assessing CRS. Sensitivities of B-scan US were significantly lower regarding the maxillary sinus (88%), the ethmoid sinus (53%), and the frontal sinus (45%). The highest overall sensitivity was observed for assessing the pathology of the maxillary sinus. (4) Conclusions: We observed high accuracy with CT, confirming its importance in preoperative imaging in CRS. Despite the high US expertise of all investigators and a standardized examination protocol, the validity of CT was significantly higher than US. Ultrasound of the PNS sinuses is applicable in everyday clinical practice but lacks diagnostic accuracy. Nevertheless, it might serve as a complementary hands-on screening tool to directly correlate the clinical findings in patients with PNS disease.

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Section: Discussionsupporting

confidence: 90%

Multicenter Observational Study to Evaluate the Diagnostic Value of Sonography in Patients with Chronic Rhinosinusitis

et al. 2022

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“…A shortcoming of our case presentation is the use of only a single imaging modality. Retrospectively, we believe that an expanded imaging protocol, including magnetic resonance imaging and ultrasound, all with contrast, would have enhanced our preoperative diagnosis and treatment planning, as well as follow-up [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Challenges of Sinonasal Pleomorphic Adenoma

Konsulov,

Milkov,

Markov

et al. 2024

Cureus

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Pleomorphic adenomas (PAs) are benign tumors of the salivary glands. Rarely, they arise in the sinonasal cavity, presenting as well-defined, homogeneous soft tissue masses, causing expansive bony changes. The significance of PAs is the possibility of giving rise to malignant carcinoma - “carcinoma ex-pleomorphic adenoma” (CXPA).Here, we present the case of a 64-year-old female complaining of progressive unilateral congestion and external nose deformation, mostly along the left contour of the radix, with epiphora of the ipsilateral eye. Eventually, a tumor began protruding from the left naris. The computed tomography excluded osteolysis, while the surgical procedure discovered the inferior turbinate as the origin of the tumor. In addition, the ipsilateral maxillary sinus was found to have developed secondary sinusitis. After complete surgical excision, the histological result was sinonasal melanoma, but following no progression of the disease, a second pathologist with additional immunohistochemical markers (HMB-45 (human melanoma black 45) negative, Melan-A (melanoma antigen recognized by T-cells 1) negative, S100 (protein soluble in 100% ammonium sulfate at neutral pH) positive, panCK AE1/AE3 (pan cytokeratin antibodies AE1 and AE3) negative, p63 (tumor protein 63) negative, Ki-67 (marker of proliferation Kiel 67) 10%, CD68 (cluster of differentiation 68) negative, CK7 (cytokeratin 7) negative, and CDX2 (caudal-type homeobox 2) negative) placed the definitive diagnosis of PA.PA of the inferior turbinate is an extremely rare finding, with the clinical symptoms being unspecific. Sometimes, SOX-10 (SRY-box transcription factor 10) positivity can mislead to malignant melanoma, as in our case, which is why a broad panel of immunohistochemical markers is critical for the definitive diagnosis.

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“…However, we believe that the lack of technical equipment necessary to perform MRI should not delay the initiation of treatment when the clinical suspicion is high, or when the histopathological diagnosis is positive. In the context of the COVID-19 pandemic, the use of ultrasound for paranasal sinus imaging can be considered [31].…”

Section: Discussionmentioning

confidence: 99%

COVID-19-Associated Rhino-Orbital Mucormycosis: Histological and Electron Microscopy Characteristics

Jeican,

Horhat,

Dumitru

et al. 2024

Diagnostics

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COVID-19-associated rhino-orbital mucormycosis has become a new clinical entity. This study’s aim was to evaluate the histopathological and ultramicroscopic morphological aspects of this fungal infection. This was an observational retrospective study on eight patients from three tertiary centers in Romania. The tissue samples collected during functional endoscopic sinus surgery were studied through histopathological examination, scanning electron microscopy, and transmission electron microscopy. In the histopathological examination, the morphological aspects characteristic of mucormycosis in all cases were identified: wide aseptate hyphae with right-angle ramifications, which invade blood vessels. One case presented perineural invasion into the perineural lymphatics. And in another case, mucormycosis–aspergillosis fungal coinfection was identified. Through scanning electron microscopy, long hyphae on the surface of the mucosa surrounded by cells belonging to the local immune system were identified in all samples, and bacterial biofilms were identified in half of the samples. Through transmission electron microscopy, aseptate hyphae and bacterial elements were identified in the majority of the samples. Rhino-orbital-cerebral mucormycosis associated with COVID-19 produces nasal sinus dysbiosis, which favors the appearance of bacterial biofilms. The way in which the infection develops depends on the interaction of the fungi with cells of the immune system.

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Ultrasonography used in the diagnosis of chronic rhinosinusitis: From experimental imaging to clinical practice

Cited by 7 publications

References 12 publications

Multicenter Observational Study to Evaluate the Diagnostic Value of Sonography in Patients with Chronic Rhinosinusitis

Multicenter Observational Study to Evaluate the Diagnostic Value of Sonography in Patients with Chronic Rhinosinusitis

Diagnostic Challenges of Sinonasal Pleomorphic Adenoma

COVID-19-Associated Rhino-Orbital Mucormycosis: Histological and Electron Microscopy Characteristics

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