Ultrasonography and dual-energy computed tomography: impact for the detection of gouty deposits

Schwabl, Christoph; Taljanovic, Mihra S.; Widmann, Gerlig; Teh, James; Klauser, Andrea

doi:10.14366/usg.20063

Cited by 12 publications

(25 citation statements)

References 59 publications

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“…MSU crystal deposition can result in end-organ damage in the kidneys and heart [ 40 ]. Gout has been associated with diabetes, obesity, hyperlipidemia, metabolic syndrome, insulin resistance, hypertension, renal disease, stroke, neurodegenerative diseases, and cardiac disease, and can lead to premature death [ 1 , 7 , 13 , 17 , 22 , 23 , 35 , 39 , 41 , 42 , 43 , 44 , 45 , 46 ]. Gout is not associated with an increased risk of fractures [ 47 ].…”

Section: Clinicalmentioning

confidence: 99%

“…There are four phases of gout: asymptomatic hyperuricemia, and acute, intercritical, and chronic gout. Acute gouty arthropathy is typically monoarticular and most commonly involves the lower limb, particularly the first metatarsophalangeal (MTP) joint, known as podagra, which is seen in greater than 50 percent of patients [ 4 , 13 , 14 , 16 , 17 , 18 , 19 , 22 , 23 , 36 , 48 , 49 , 50 , 51 ]. The hands, tarsal joints, knees, elbows, ankles, and bursae are other common sites of involvement [ 16 , 17 , 22 , 23 ].…”

Section: Clinicalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Gout is the most common cause of inflammatory arthritis in adults [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. It affects approximately 1–2% of the population of industrialized countries and is more common in older males [ 1 , 6 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Gouty arthropathy occurs secondary to abnormal purine metabolism, the end product of which is uric acid, combined with underexcretion or overproduction of uric acid, resulting in sustained hyperuricemia.…”

Section: Introductionmentioning

confidence: 99%

“…Gouty arthropathy occurs secondary to abnormal purine metabolism, the end product of which is uric acid, combined with underexcretion or overproduction of uric acid, resulting in sustained hyperuricemia. Hyperuricemia, above the local solubility, can lead to monosodium urate (MSU) crystal deposition ( Figure 1 ) in joints, on the surface of the hyaline cartilage and within periarticular soft tissues such as tendons, ligaments, retinacula, and bursae, with resulting inflammatory response [ 7 , 13 , 14 , 16 , 17 , 19 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. Gout predominantly affects the peripheral joints, but the axial skeleton may also be affected [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

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Gouty Arthropathy: Review of Clinical Manifestations and Treatment, with Emphasis on Imaging

Weaver

Vina

Munk

et al. 2021

JCM

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Gout, a crystalline arthropathy caused by the deposition of monosodium urate crystals in the articular and periarticular soft tissues, is a frequent cause of painful arthropathy. Imaging has an important role in the initial evaluation as well as the treatment and follow up of gouty arthropathy. The imaging findings of gouty arthropathy on radiography, ultrasonography, computed tomography, dual energy computed tomography, and magnetic resonance imaging are described to include findings of the early, acute and chronic phases of gout. These findings include early monosodium urate deposits, osseous erosions, and tophi, which may involve periarticular tissues, tendons, and bursae. Treatment of gout includes non-steroidal anti-inflammatories, colchicine, glucocorticoids, interleukin-1 inhibitors, xanthine oxidase inhibitors, uricosuric drugs, and recombinant uricase. Imaging is critical in monitoring response to therapy; clinical management can be modulated based on imaging findings. This review article describes the current standard of care in imaging and treatment of gouty arthropathy.

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Section: Clinicalmentioning

confidence: 99%

Section: Clinicalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Gouty Arthropathy: Review of Clinical Manifestations and Treatment, with Emphasis on Imaging

Weaver

Vina

Munk

et al. 2021

JCM

Self Cite

View full text Add to dashboard Cite

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Association of the Quantity, Duration, and Type of Alcohol Consumption on the Development of Gouty Tophi

Han

Lü

et al. 2022

Arthritis Care & Research

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Objective To examine the association of alcohol consumption with the presence and development of ultrasound (US)–detected tophi and subcutaneous tophi in a Chinese gout population. Methods A total of 554 patients with gout who underwent US and physical examination of the most frequently involved joints in gout were included in this study. Multivariable analysis was performed to assess the associations of the duration, quantity, and type of alcohol consumption with the presence, size, and number of US‐detected tophi and subcutaneous tophi. Results Compared to non‐drinkers, excessive drinkers (>70 gm/week), long‐term drinkers (≥10 years), and spirits drinkers had a greater proportion, size, and number of US‐detected tophi and subcutaneous tophi (all P < 0.05). After adjusting for confounders, excessive drinking (>70 gm/week) (odds ratio [OR] 1.79 [2.00 after adjustment]), long‐term alcohol consumption (≥10 years) (OR 1.96 [2.17 after adjustment]), and spirits consumption of (OR 1.81 [2.10 after adjustment]) were significantly associated with the presence of US‐detected tophi and subcutaneous tophi (all P < 0.05), with the highest ORs among the identified risk factors. Among patients who already had US‐detected tophi or subcutaneous tophi, moderate drinking (≤70 gm/week) was associated with larger or multiple tophi (all P < 0.05). Conclusion Longer duration and higher quantity of alcohol consumption as well as spirits consumption are predictors for the development of US‐detected tophi and subcutaneous tophi in patients with gout. Among individuals who have US‐detected tophi and subcutaneous tophi, weekly alcohol consumption leads to the development of tophi regardless of amount consumed.

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Review: The Role of Dual-Energy Computed Tomography in Detecting Monosodium Urate Deposits in Vascular Tissues

Held,

Haschka,

Lacaita

et al. 2024

Curr Rheumatol Rep

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Purpose of Review To highlight novel findings in the detection of monosodium urate deposits in vessels using dual energy computed tomography, and to discuss the potential clinical implications for gout and hyperuricemia patients. Recent Findings Gout is an independent risk factor for cardiovascular disease. However, classical risk calculators do not take into account these hazards, and parameters to identify patients at risk are lacking. Monosodium urate measured by dual energy computed tomography is a well-established technology for the detection and quantification of monosodium urate deposits in peripheral joints and tendons. Recent findings also suggest its applicability to identify vascular urate deposits. Summary Dual energy computed tomography is a promising tool for detection of cardiovascular monosodium urate deposits in gout patients, to better delineate individuals at increased risk for cardiovascular disease.

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Ultrasonography and dual-energy computed tomography: impact for the detection of gouty deposits

Cited by 12 publications

References 59 publications

Gouty Arthropathy: Review of Clinical Manifestations and Treatment, with Emphasis on Imaging

Gouty Arthropathy: Review of Clinical Manifestations and Treatment, with Emphasis on Imaging

Association of the Quantity, Duration, and Type of Alcohol Consumption on the Development of Gouty Tophi

Review: The Role of Dual-Energy Computed Tomography in Detecting Monosodium Urate Deposits in Vascular Tissues

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