Ultrasonography and computer-assisted assessment of postpartum uterine echotexture and its relationship with peripheral oxidative stress biomarkers in goats

Samir, Haney; Radwan, Faten; El-Khawagah, Ahmed R.M.; Kandiel, Mohamed M.M.; Sayed, Mohamed; Elfadadny, Ahmed; Karen, Aly; El-Sherbiny, Hossam R.

doi:10.1016/j.smallrumres.2023.106947

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…Ultrasonography is considered as a substantial tool for evaluating animal reproductive organs (El-Sherbiny et al, 2023;Samir et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

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Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

El‐Sherbiny,

Samir,

Youssef

et al. 2024

Animal Physiology Nutrition

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This experiment was designed to investigate the impact of curcumin‐olive oil nanocomposite (CONC) supplementation on uteroplacental hemodynamics and ultrasonographic measurements as well as maternal oxidative status in midgestating goats. Twelve synchronized pregnant goats (85.58 ± 1.08 days of gestation; mean ± SD) were uniformly assigned to two groups (n = 6/group); the first group received daily oral supplementation of CONC (3 mg/kg body weight; nanocurcumin [NC] group) for 32 days, and the second group was offered physiological saline (control) following the NC group timeline. The goats of both groups were examined at 3‐day intervals for middle uterine (MUA) and umbilical (UMA) arteries hemodynamics (pulsatility index [PI], resistive index [RI], systole/diastole [S/D] and blood flow rate [BFR]) and diameters, uteroplacental thickness (UPT), placentomes' diameter (PD) and echogenicity, steroid hormones (progesterone and estradiol 17β), oxidative biomarkers (total antioxidant capacity [TAC], catalase [CAT], malondialdehyde [MDA]), nitric oxide (NO) and blood cells DNA integrity. The UPT (p = 0.012) and PD (p = 0.021) values were higher in the NC group than in their counterparts' control group (D11–32). There were increases in diameter (p = 0.021 and p = 0.012) and decreases (p = 0.021, p = 0.016 and p = 0.041 [MUA]; p = 0.015, p = 0.023 and p = 0.011 [UMA] respectively) in Doppler indices (PI, RI and S/D) of the MUA and UMA in the NC group compared to the control group (D14–32). On D20–32 (MUA) and D14–32 (UMA), the NC goats had higher BFR than the control group (p = 0.021, 0.018 respectively). The means of blood cells with fragmented DNA were lower (p = 0.022) in the NC group than in the control group on Days 8 and 21 postsupplementation. There were increases in CAT and NO (D20–32; p = 0.022 and p = 0.004 respectively), and TAC (D17–32; p = 0.007) levels in the NC goats compared to the control ones. The NC group had lower (p = 0.029) concentrations of MDA than the control group on Day 20 postsupplementation onward. In conclusion, oral supplementation of CONC improved uteroplacental blood flow and the antioxidant capacity of midgestating goats.

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“…Ultrasonography is considered as a substantial tool for evaluating animal reproductive organs (El-Sherbiny et al, 2023;Samir et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasonography is considered as a substantial tool for evaluating animal reproductive organs (El‐Sherbiny et al, 2023; Samir et al, 2023). Improving uteroplacental hemodynamics is crucial for a stable and growing pregnancy, especially in dams bearing more than one foetus.…”

Section: Discussionmentioning

confidence: 99%

Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

El‐Sherbiny,

Samir,

Youssef

et al. 2024

Animal Physiology Nutrition

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“…Good images of B-mode ultrasonography of the placentomes (2–3 ones near the fetus) were snapped frozen and stored for further echotexture evaluation using a computer image analysis software (Adobe Photoshop CC software, USA) as previously stated (Polat et al 2015 ; Samir et al 2023d ). Briefly, 3 square spots (0.5 × 0.5 cm) were positioned on the placentome picture while avoiding artifacts (Fig.…”

Section: Methodsmentioning

confidence: 99%

Emotional temperaments in advanced pregnant goats and its relationship with the feto-maternal blood flow and placentome echotexture

Samir,

Swelum,

Farag

et al. 2024

Vet Res Commun

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The current study aimed to investigate the effect of xylazine sedation (non-sedated versus sedated conditions) and animal temperament on the fetal and maternal hemodynamics during the late stage of gestation in goats. In addition, it aimed to study the concentrations of cortisol and the echotexture of the placentome. Fourteen goats were assigned into two equal groups (n = 7, each) based on the animal’s emotional temperament (calm versus nervous groups). All goats were examined for assessment of the blood flow within the fetal aorta (FA), umbilical artery (UMA), and middle uterine artery (MUA) using color-pulsed Doppler ultrasonography. Goats were exposed to light sedation using the recommended dose of xylazine (0.05 mg/Kg Bw) intramuscularly. Goats in each group were reassessed for the studied parameters after sedation. Blood samples were drawn to determine the concentrations of cortisol. Placentome echotexture pixel intensity (PXI) was evaluated using computer image analysis software. Results revealed the significant impact of the xylazine sedation on the Doppler indices of the blood flow within the measured arteries (FA, UMA, and MUA), the PXI of placentome echotexture, and cortisol concentrations. The emotional temperament of goats had significant effects on the blood flow parameters of the MUA and UMA, concentrations of cortisol, and the PXI of the placentome. The interaction effect (sedation x temperament) was noticed in the measured parameters of the UMA blood flow, fetal heart rate, and cortisol concentrations. In conclusion, xylazine sedation and emotional temperaments induced alterations in the echotexture of the placentomes as well as the hemodynamic parameters of late-stage pregnant goats without affecting the pregnancy outcomes.

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“…Due to climatic changes and global warming, heat stress has become a worldwide problem and has gained more attention, especially in tropical and subtropical countries. Heat stress has substantial economic effects on animal performance and costs the global animal industry millions of dollars every year due to poor animal reproductive performances [1,2]. The effects of heat stress on reproduction are more profound because the affected animals showed reduced fertility for several weeks after the onset of thermal stress as a result of the response of the hypothalamic-hypophyseal-gonadal axis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Acute Melatonin Injection on Metabolomic and Testicular Artery Hemodynamic Changes and Circulating Hormones in Shiba Goats under Sub-Tropical Environmental Conditions

Samir

Mandour

Radwan

et al. 2023

Animals

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The beneficial effects of melatonin were investigated to mitigate various detrimental effects and toxicity on reproductive performance. The present study aimed, for the first time, to explore the effect of intravenous melatonin injection on testicular artery hemodynamics (TH) and metabolomic changes, reproductive hormones in heat-stressed bucks. Ten bucks were randomly split into two groups (five each): (1) the melatonin group, treated with a single intravenous dose of melatonin solution containing 10 mg melatonin each, and (2) the control group, which was treated with 10 mL of the vehicle without melatonin. Changes in the TH at the level of the supra testicular artery (STA) were assessed by triplex ultrasonography just before (0 h) and at 0.5, 2, 7, 24, and 168 h after melatonin or vehicle administration. Doppler velocity parameters of peak systolic velocity (PSV; cm/s), end-diastolic velocity (EDV; cm/s), and time average maximum velocity (TAMAX; cm/s) were measured. Doppler indices (resistive index; RI and pulsatility index; PI), systole/diastole (S/D) ratio and total arterial blood flow volume (TABFV; ml/minute) were measured. Peripheral concentrations of FSH, LH, inhibin, melatonin, testosterone (T), estradiol (E2), and cortisol were measured just before injection (0 h) and at 0.5, 2, 7, and 24 h and daily up to day 7 post administration in both groups. Results revealed reductions in the RI values and increases in the TABFV in the melatonin group compared to the control one, especially 2 h after administration. Significant increases in concentrations of FSH, T, E2, and melatonin and decreases in cortisol and inhibin in the melatonin group compared to the control one. Plasma metabolomic analysis at 2 h indicated the up-regulation of L-glutamine, L-arginine, sorbitol, D-glucose, ascorbic acid, and ornithine and the down-regulation of D-xylose, D-arabitol, ribitol, and oleic acid in the melatonin versus the control group. In conclusion, acute administration of melatonin (10 mg IV) enhanced testicular artery blood flow and plasma reproductive hormones in the Shiba goat under heat-stress circumstances.

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Ultrasonography and computer-assisted assessment of postpartum uterine echotexture and its relationship with peripheral oxidative stress biomarkers in goats

Cited by 6 publications

References 43 publications

Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

Emotional temperaments in advanced pregnant goats and its relationship with the feto-maternal blood flow and placentome echotexture

Effect of Acute Melatonin Injection on Metabolomic and Testicular Artery Hemodynamic Changes and Circulating Hormones in Shiba Goats under Sub-Tropical Environmental Conditions

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