Ultrasonographic vascular mechanics to assess arterial stiffness: a review

Teixeira, Rogério; Vieira, Maria João; Gonçalves, Alexandra; Cardim, Nuno; Gonçalves, Lino

doi:10.1093/ehjci/jev287

Cited by 61 publications

(77 citation statements)

References 100 publications

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“…Vascular strain measurements, a measure of localized arterial stiffness (42), were obtained immediately before hemodynamic measurements with a high-frequency linear array transducer (ML6-15, GE Healthcare) connected to a high-resolution ultrasound machine (Vivid E9, GE Healthcare). Circumferential strain measurements were made from cross-sectional images of the right common carotid (CCA) and FA by using speckle-tracking software (BT13, EchoPac, GE Healthcare) from the last three cardiac cycles at the end of two HX bouts and two NX bouts or SHAM (7,30).…”

Section: Methodsmentioning

confidence: 99%

Intermittent hypoxia and arterial blood pressure control in humans: role of the peripheral vasculature and carotid baroreflex

Tremblay

Boulet

Tymko

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

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Intermittent hypoxia (IH) occurs in association with obstructive sleep apnea and likely contributes to the pathogenesis of hypertension. The purpose of this study was to examine the putative early adaptations at the level of the peripheral vasculature and carotid baroreflex (CBR) that may promote the development of hypertension. Ten healthy male participants (26 ± 1 yr, BMI = 24 ± 1 kg/m(2)) were exposed to 6 h of IH (1-min cycles of normoxia and hypoxia) and SHAM in a single-blinded, counterbalanced crossover study design. Ambulatory blood pressure was measured during each condition and the following night. Vascular strain of the carotid and femoral artery, a measure of localized arterial stiffness, and hemodynamic shear patterns in the brachial and femoral arteries were measured during each condition. Brachial artery reactive hyperemia flow-mediated vasodilation was assessed before and after each condition as a measure of endothelial function. CBR function and its control over leg vascular conductance (LVC) were measured after each condition with a variable-pressure neck chamber. Intermittent hypoxia 1) increased nighttime pulse pressure by 3.2 ± 1.3 mmHg, 2) altered femoral but not brachial artery hemodynamics, 3) did not affect brachial artery endothelial function, 4) reduced vascular strain in the carotid and possibly femoral artery, and 5) shifted CBR mean arterial pressure (MAP) to higher MAP while blunting LVC responses to CBR loading. These results suggest limb-specific vascular impairments, reduced vascular strain, and CBR resetting combined with blunted LVC responses are factors in the early pathogenesis of IH-induced development of hypertension.

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Section: Methodsmentioning

confidence: 99%

Intermittent hypoxia and arterial blood pressure control in humans: role of the peripheral vasculature and carotid baroreflex

Tremblay

Boulet

Tymko

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

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“…To be noted, PWV value of LCCA was greater in SiNPs group (6.0 mg/kg•bw) when compared to control group. As a classic indicator of vascular stiffness [30], the increase in PWV caused by SiNPs suggested SiNPs exposure could exacerbate vascular stiffening of ApoE -/mice.…”

Section: Vascular Stiffening Promoted By Sinps In Apoe -/Micementioning

confidence: 99%

Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE-/- mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage

Zhao

et al. 2020

Preprint

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Abstract Background: The biosafety concern of silica nanoparticles (SiNPs) is rapidly expanding alongside with its mass production and extensive applications. The cardiovascular effects of SiNPs exposure have been confirmed. However, the interaction between SiNPs exposure and atherosclerosis, and the underlying mechanisms still remain unknown. Thereby, this study aimed to explore the effects of SiNPs on the progression of atherosclerosis, and to investigate related mechanisms. Results: We firstly investigated the in vivo effects of SiNPs exposure on atherosclerosis via intratracheal instillation of ApoE -/- mice fed a Western diet. Ultrasound microscopy showed a significant increase of pulse wave velocity (PWV) compared to the control group. Histopathological investigation reflected a greater plaque burden in the aortic root of SiNPs-exposed ApoE -/- mice. When compared to the control, serum levels of total triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) were elevated after SiNPs exposure. Moreover, intensified macrophage infiltration and endoplasmic reticulum (ER) stress was occurred in plaques after SiNPs exposure, as evidenced by the upregulated CD68 and CHOP expressions. Further in vitro , SiNPs was confirmed to activate ER stress and induce lipid accumulation in mouse macrophage, RAW264.7. Mechanistic analyses showed that 4-PBA (a classic ER stress inhibitor) pretreatment greatly alleviated SiNPs-induced macrophage lipid accumulation, and reversed the elevated CD36 expression by SiNPs. Conclusions: Our results firstly revealed the acceleratory effect of SiNPs on the progression of atherosclerosis in ApoE -/- mice, which was related to lipid accumulation caused by ER stress-mediated upregulation of CD36 expression in macrophage.

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“…предложили на основе циркумференциальной деформации проводить расчет артериальной жесткости (β2) [3]. В литературе представлена широкая валидация этого показателя и изучение его диагностической и прогностической ценности у взрослых [2,[4][5][6]. Однако у детей исследования деформации и артериальной жесткости единичны, а у детей первого года жизни не проводились.…”

Section: Introductionunclassified

“…Учитывая потенциал циркумференциальной деформации и жесткости, необходимо получить нормативные значения у детей первого года жизни. Для оценки функциональных сосудистых характеристик на уровне восходящего и брюшного отделов аорты и в обеих ОСА оценивали фракцию изменения площади артерии (ФИП) и артериальную жесткость (β2) [3,5,7]. ФИП рассчитывали как процентное изменение площади поперечного сечения изучаемого сегмента аорты или ОСА между систолой и диастолой (наибольшая площадь поперечного сечения артерии -наименьшая площадь поперечного сечения артерии) / (наибольшая площадь поперечного сечения артерии) × 100) [5,7].…”

Section: Introductionunclassified

“…Для оценки функциональных сосудистых характеристик на уровне восходящего и брюшного отделов аорты и в обеих ОСА оценивали фракцию изменения площади артерии (ФИП) и артериальную жесткость (β2) [3,5,7]. ФИП рассчитывали как процентное изменение площади поперечного сечения изучаемого сегмента аорты или ОСА между систолой и диастолой (наибольшая площадь поперечного сечения артерии -наименьшая площадь поперечного сечения артерии) / (наибольшая площадь поперечного сечения артерии) × 100) [5,7]. Для расчета артериальной жесткости использована формула: ln (систолическое артериальное давление / диастолическое артериальное давление) / циркумференциальная деформация [3].…”

Section: Introductionunclassified

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Ultrasonographic evaluation of segmental function of the aorta and carotid arteries in healthy infants

Синельников¹,

Орехова²,

Матановская³

2020

PKiK

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Aim. To study the ultrasonographic parameters of segmental function and mechanics of the aorta and carotid arteries in healthy infants.Methods. We observed 114 healthy infants (age range, 1–12 months; boys 52.6%; mean body surface area (BSA): 0.35 ± 0.8 m2). Echocardiography was performed with an Acuson S 2000 (Siemens Medical Systems, Mountain View, CA, USA) using vector velocity imaging (VVI). The following parameters were estimated at the level of the ascending and abdominal aorta and in the common carotid arteries (CCA): maximum and minimum diameters (mm); circumferential strain (CS, %) and circumferential strain rate (CSR, s-1); fraction area change (FAC, %); arterial stiffness (β2).Results. The maximum and minimum diameters of the examined segments of the aorta and CCA, FAC of the aorta and CCA, CS and CSR of the aorta and CCA showed a correlation with BSA, age, LV stroke index, and LV myocardial mass index. None of the estimated parameters showed a correlation with sex, arterial blood pressure, or left ventricular ejection fraction. The highest CS values were found in CCA 7.85 ± 2.8% [compared with 5.4 ± 0.98% (p = 0.0001) in the ascending aorta and 6.7 ± 1.8 % (p = 0.03) in the abdominal aorta). CSR in the CCA (0.84 ± 0.22 s-1) was significantly higher than that at the abdominal aorta level (0.67 ± 0.24 s-1, p = 0.001), but lower than that in the ascending aorta (1.3 ± 0.3 s-1, p = 0.00001).Conclusion. The parameters of segmental function of the aorta and common carotid artery obtained in our research can serve as normative reference for children in the first year of life. The functional parameters of the aorta and common carotid artery depend on the age and BSA.Received 15 December 2019. Revised 26 February 2020. Accepted 27 February 2020.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.

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Ultrasonographic vascular mechanics to assess arterial stiffness: a review

Cited by 61 publications

References 100 publications

Intermittent hypoxia and arterial blood pressure control in humans: role of the peripheral vasculature and carotid baroreflex

Intermittent hypoxia and arterial blood pressure control in humans: role of the peripheral vasculature and carotid baroreflex

Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE-/- mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage

Ultrasonographic evaluation of segmental function of the aorta and carotid arteries in healthy infants

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