Ultrasonographic Screening for Thyroid Cancer in Siblings of Patients with Apparently Sporadic Papillary Carcinoma

Rosário, Pedro Weslley; Filho, Augusto Flávio Campos Mineiro; Prates, Brenda Sá Senna; Silva, Lívia Cristina Oliveira; Lacerda, Rafaela Xavier; Calsolari, Maria Regina

doi:10.1089/thy.2011.0349

Cited by 35 publications

(24 citation statements)

References 11 publications

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“…However, updated recommendations for US screening have been put forth for both the PTEN hamartoma tumor syndrome and APC-associated polyposis (91,92,106). In addition, in nonsyndromic FNMTC, US surveillance of family members has been shown to detect earlier stages of disease as reflected by smaller tumor size (0.8 vs. 2.85 cm; p < 0.001), a lower incidence of lymph node metastasis (23.2% vs. 65.6%; p < 0.001) as well as a lower incidence of ETE (20.9% vs. 56.2%; p = 0.002) compared to the proband (107).…”

Section: In Children With Dtcmentioning

confidence: 99%

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Francis

Waguespack

Bauer

et al. 2015

Thyroid

921

1,307

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Background: Previous guidelines for the management of thyroid nodules and cancers were geared toward adults. Compared with thyroid neoplasms in adults, however, those in the pediatric population exhibit differences in pathophysiology, clinical presentation, and long-term outcomes. Furthermore, therapy that may be recommended for an adult may not be appropriate for a child who is at low risk for death but at higher risk for long-term harm from overly aggressive treatment. For these reasons, unique guidelines for children and adolescents with thyroid tumors are needed. Methods: A task force commissioned by the American Thyroid Association (ATA) developed a series of clinically relevant questions pertaining to the management of children with thyroid nodules and differentiated thyroid cancer (DTC). Using an extensive literature search, primarily focused on studies that included subjects £ 18 years of age, the task force identified and reviewed relevant articles through April 2014. Recommendations were made based upon scientific evidence and expert opinion and were graded using a modified schema from the United States Preventive Services Task Force. Results: These inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules. Recommendations for the evaluation, treatment, and follow-up of children and adolescents with DTC are outlined and include preoperative staging, surgical management, postoperative staging, the role of radioactive iodine therapy, and goals for thyrotropin suppression. Management algorithms are proposed and separate recommendations for papillary and follicular thyroid cancers are provided.

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Section: In Children With Dtcmentioning

confidence: 99%

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Francis

Waguespack

Bauer

et al. 2015

Thyroid

921

1,307

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“…Although these methods are most often neither sensitive nor specific, some of the data they provide are indicative of a higher risk of malignancy (5,(10)(11)(12)(13)(14) (Table 2). Nodules incidentally detected on FDG-PET (focal uptake) in cancer patients a Confirmation of these data as being suspicious of malignancy requires comparison with the results of imaging exams.…”

Section: Approach To Patients With Thyroid Nodules What Clinical Infomentioning

confidence: 99%

Thyroid nodules and differentiated thyroid cancer: update on the Brazilian consensus

Rosário

Ward

Carvalho

et al. 2013

Arq Bras Endocrinol Metab

115

121

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Thyroid nodules are frequent findings, especially when sensitive imaging methods are used. Although thyroid cancer is relatively rare, its incidence is increasing, particularly in terms of small tumors, which have an uncertain clinical relevance. Most patients with differentiated thyroid cancer exhibit satisfactory clinical outcomes when treatment is appropriate, and their mortality rate is similar to that of the overall population. However, relapse occurs in a considerable fraction of these patients, and some patients stop responding to conventional treatment and eventually die from their disease. Therefore, the challenge is how to identify the individuals who require more aggressive disease management while sparing the majority of patients from unnecessary treatments and procedures. We have updated the Brazilian Consensus that was published in 2007, emphasizing the diagnostic and therapeutic advances that the participants, representing several Brazilian university centers, consider most relevant in clinical practice. The formulation of the present guidelines was based on the participants' experience and a review of the relevant literature. Arq Bras Endocrinol Metab. 2013;57(4):240-64 Keywords Thyroid nodules; thyroid cancer; Brazilian consensus; update RESUMO Nódulos tireoidianos são muito frequentes, sobretudo quando se empregam métodos sensí-veis de imagem. Embora o câncer seja proporcionalmente raro, sua incidência vem aumentando, especialmente de tumores pequenos, cuja evolução clínica é incerta. A maioria dos pacientes com carcinoma diferenciado de tireoide evolui bem quando adequadamente tratada, com índices de mortalidade similares à população geral. Por outro lado, um percentual não desprezível apresenta recidivas e alguns eventualmente não respondem às terapias convencionais, evoluindo para óbito. Assim, o desafio é distinguir os pacientes merecedores de condutas mais agressivas e, ao mesmo tempo e não menos importante, poupar a maioria de tratamentos e procedimentos desnecessários. Atualizamos o Consenso Brasileiro publicado em 2007, ressaltando os avanços diagnósticos e terapêuticos que os participantes, de diferentes Centros Universitários do Brasil, consideram mais relevantes para prática clínica. A elaboração dessas diretrizes foi baseada na experiência dos participantes e revisão da literatura pertinente. Arq Bras Endocrinol Metab. 2013;57(4):240-64 Descritores

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“…Rosario and colleagues screened the siblings of patients with thyroid cancer and found that screening was associated with an earlier diagnosis because tumors were detected at a smaller size, and with lower rate of lymph node metastases and extrathyroidal invasion. 11 …”

Section: Introductionmentioning

confidence: 99%

Prospective screening in familial nonmedullary thyroid cancer

Sadowski

Gesuwan

et al. 2013

Surgery

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Background Approximately 8% of non-medullary thyroid cancers are familial. The optimal age for screening in familial non-medullary thyroid cancer (FNMTC) is unknown. Method Kindreds with FNMTC (2 or more first-degree relatives affected) were prospectively screened by thyroid ultrasound. Results Fifteen kindreds showed an overall prevalence of thyroid nodule(s) ≥ 5 mm of 44.4% at screening; 19.2% in the second generation, and 90% in the generation anterior to the index case. The youngest age of detection was 10 years for thyroid nodules and 18 years for thyroid cancer. Thyroid nodule microcalcification at screening was associated with a higher risk of cancer (p < 0.05). Family members diagnosed with thyroid cancer by ultrasound screening were diagnosed at a younger age and had a lower rate of extrathyroidal invasion (p < 0.05). Conclusions In FNMTC, first-degree relatives 10 years or older, including the generation anterior to the index case, should have thyroid ultrasound screening. This may result in earlier diagnosis.

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Ultrasonographic Screening for Thyroid Cancer in Siblings of Patients with Apparently Sporadic Papillary Carcinoma

Abstract: The present results favor ultrasonographic screening of first-degree relatives of patients with apparently sporadic multicentric PTC, especially among women.

Cited by 35 publications

References 11 publications

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Thyroid nodules and differentiated thyroid cancer: update on the Brazilian consensus

Prospective screening in familial nonmedullary thyroid cancer

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