Ultrasonographic prevalence and characteristics of non-palpable thyroid incidentalomas in a hospital-based population in a sub-Saharan country

Moifo, Boniface; Tapouh, Jean Roger Moulion; Fomekong, Sylviane Dongmo; Djomou, François; Wankie, Emmanuella Manka’a

doi:10.1186/s12880-017-0194-8

Cited by 12 publications

(20 citation statements)

References 19 publications

(45 reference statements)

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“…The gender disparity of the presence of TNs was in accordance with previous studies. 5 , 20 , 21 Interestingly, this study found a higher odds ratio (OR) of TNs (3.36, 95% confidence interval [CI] =1.97–5.75; P <0.001) in women compared with previous studies, which indicates a potentially increasing trend of gender disparity on TNs with age. Further studies are needed to verify this trend.…”

Section: Discussioncontrasting

confidence: 63%

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Thyroid nodules in centenarians: prevalence and relationship to lifestyle characteristics and dietary habits

Yao¹,

Chen²,

Wu³

et al. 2018

CIA

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BackgroundThyroid nodules (TNs) are common thyroid lesions in older population. Few studies have focused on the prevalence of TNs and their relationship to lifestyle characteristics and dietary habits in centenarians. The current study aimed at determining the prevalence of TNs in Chinese centenarians by using high-resolution ultrasound (US) equipment and at investigating its relationship to lifestyle characteristics and dietary habits.Participants and methodsThe current study was part of the China Hainan Centenarian Cohort Study that was conducted in Hainan, an iodine-sufficient region in People’s Republic of China. A total of 874 permanent residents aged ≥100 years (mean age =102.8±2.8 years) without any missing data were included in the analysis.ResultsAmong the participants, 649 of them were detected at least one TN under the US examinations. The overall prevalence rate of TNs was 74.3%. The prevalence of TNs was higher in participants who were women, had hypertension, had diabetes, and were underweight compared with their counterparts. Multivariate logistic regression analyses showed that being female, hypertensive, and diabetic; betel quid consumption; and red meat consumption were independent risk factors, while being underweight and nut consumption were independent protective factors for TNs.ConclusionOur findings indicate that the presence of TNs was highly prevalent in Chinese centenarians, particularly in women. In addition to gender, having hypertension, having diabetes, and being underweight, the presence of TNs was independently associated with betel quid, red meat, and nut consumption. Further prospective studies are warranted to verify these associations in populations from different age strata, races, cultures, and iodine supplementation.

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Section: Discussioncontrasting

confidence: 63%

“…According to the previous studies, the prevalence of TNs in the senior population was 73.7% in People’s Republic of China, 54.9% in Korea, and 46.2% in Cameroon. 5 , 20 , 21 The differences in the prevalence may be due to age, gender, race, culture, dietary patterns, and iodine supplements. 7 , 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

Thyroid nodules in centenarians: prevalence and relationship to lifestyle characteristics and dietary habits

Yao¹,

Chen²,

Wu³

et al. 2018

CIA

View full text Add to dashboard Cite

show abstract

“…The gender disparity of the presence of TNs was in accordance with previous studies [5,19,20]. Interestingly, this study found a higher odds ratio of TNs (3.36, 95%CI = 1.97-5.75; P < 0.001) in females than previous studies, which indicates a potentially increasing trend of gender disparity on TNs with aging.…”

Section: Discussionsupporting

confidence: 59%

“…To our best knowledge, this is the first study to report prevalence of thyroid nodules among centenarians. According to the previous studies, the prevalence of TNs in senior population was 73.7% in China [5], 54.9% in Korea [19], and 46.2% in Cameroon [20]. The differences in the prevalence may be due to age, gender, race, culture, dietary patterns, and iodine supplements [7,21,22].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Nodules in Centenarians: Prevalence and Relationship to Lifestyle Characteristics and Dietary Habits

Yao

Chen

et al. 2018

Preprint

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Thyroid nodules (TNs) are common thyroid lesions in older population. Few studies focused on the prevalence of TNs and its relationship to lifestyle characteristics and dietary habits in centenarians. The current study aimed to determine the prevalence of TNs in Chinese centenarians using high-resolution ultrasound equipment and investigate its relationship to lifestyles and dietary habits. The current study was part of China Hainan Centenarian Cohort Study (CHCCS) which conducted in Hainan, an iodine sufficient region in China. A total of 874 permanent residents aged 100 years or older (mean age, 102.8 ± 2.8 years) without any missing data were included in the analysis. Among the participants, 649 of them were detected at least one thyroid nodule under the ultrasound examinations. The overall prevalence rate of TNs was 74.3%. The prevalence of TNs was higher in participants who were females, hypertension, diabetes, and underweight than their counterparts. Multivariate logistic regression analyses showed that being female, hypertension, diabetes, betel quid consumption, red meat consumption were independent risk factors, while being underweight, and nut consumption were independent protective factors for TNs. Our findings indicate that the presence of thyroid nodules was highly prevalent in Chinese centenarians, particularly in females. In addition to gender, hypertension, diabetes, and underweight, the presence of TNs was independently associated with betel quid, red meat, and nut consumptions. Further prospective studies are warranted to verify these associations in population from different age strata, races, cultures, and iodine backgrounds. 2 / 12 IntroductionThyroid nodules (TNs) are common thyroid lesions in older population. High-resolution ultrasonography has made possible the detection of asymptomatic and non-palpable thyroid nodules [1]. The prevalence of TNs detected by high-resolution ultrasonography was 19-68% based on randomly selected individuals, with annual increasing trends worldwide [2,3]. The clinical importance of TNs detection rests with the need to exclude thyroid cancer, which occurs in 5-15% of TN cases [1,4]. A recent study reported that the occurrence of TNs increased as people age, with a prevalence of 74% in a community-based sample of Chinese senior adults [5]. However, the prevalence of this lesion in centenarians remained understudied. Considering the issues mentioned above, there is a need to specifically determine the prevalence of TNs in late life, particularly in centenarians.The high prevalence rate of TNs was partly due to widespread application of high-resolution ultrasound and early diagnosis. In addition, recent studies also proposed that several risk factors could attribute to TNs. Among those risk factors, some factors were non-modifiable such as age, sex, and history of irradiation exposure, while others were modifiable including iodine intake, smoking, alcohol drinking, obesity and metabolic syndrome [5][6][7][8]. However, some other modifiable factors, inc...

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“…2 Some studies have also stated incidental findings of thyroid nodules on ultrasonography to be 50-67%. 3 Although gender is not an independent prognostic factor for thyroid cancer, men usually have a far more advanced disease as compared to women. 4 Previous radiation exposure though has a significant relation, thirty percent (30%) of patients who have previous history of radiation, develop palpable nodules and have a bad clinical outcome.…”

Section: Introductionmentioning

confidence: 99%

Histopathological examination of thyroid specimens - a single center study from Peshawar, Khyber Pakhtunkhwa

et al. 2020

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Introduction: Thyroid gland enlargement is a surgical problem that affects about a third of the world's adults. Thyroid enlargement is best diagnosed by histopathology of surgical specimen and can also give a clue about different pattern of diseases that include simple goiter, multinodular goiter, thyroiditis, adenoma, and last but not the least, carcinoma. Objective: To determine presentation of thyroid lesions based on their histopathology in patients presenting to Rehman Medical Institute (RMI), Peshawar from August 2018 to July 2019. Materials & Methods: This was a descriptive cross-sectional study, inclusive of all thyroid specimens, irrespective of age and gender, received in the Department of Pathology, Rehman Medical Institute (RMI), Peshawar, from August 2018 to July 2019. Data were retrieved and analyzed for descriptive statistics in MS Excel. Results: A total of 64 samples were collected; 56(87.5%) were non-neoplastic lesions while 08(12.5%) were neoplastic. 40(71%) multi nodular goiters, 11(19.64%) simple nodular goiter, 01(1.7%) case of Hashimoto’s thyroiditis, among neoplastic 04(50%) were found to be papillary carcinoma and 02(25%) each were follicular and medullary carcinoma. Female to male ratio was 5:3 or 1.67:1 in neoplastic lesions. Conclusion: The most common cause of goiter was multinodular goiter. Among the neoplastic lesions, follicular adenoma was the commonest, while papillary carcinoma was the most common malignant lesions. Keywords: Multinodular goiter, follicular adenoma, Papillary carcinoma, Fine needle aspiration cytology.

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Ultrasonographic prevalence and characteristics of non-palpable thyroid incidentalomas in a hospital-based population in a sub-Saharan country

Cited by 12 publications

References 19 publications

Thyroid nodules in centenarians: prevalence and relationship to lifestyle characteristics and dietary habits

Thyroid nodules in centenarians: prevalence and relationship to lifestyle characteristics and dietary habits

Thyroid Nodules in Centenarians: Prevalence and Relationship to Lifestyle Characteristics and Dietary Habits

Histopathological examination of thyroid specimens - a single center study from Peshawar, Khyber Pakhtunkhwa

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