Ultrasonographic measurement of fetal nasal bone length in the second trimester in Korean population

Jung, Euiseok; Won, Hye‐Sung; Lee, Pil Ryang; Kim, Ahm

doi:10.1002/pd.1641

Cited by 27 publications

(37 citation statements)

References 16 publications

(49 reference statements)

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“…Reference ranges for the fetal NBL in Caucasian, African-American and South-American populations have been published [5,9]. Some recent reports concluded that the fetal NBL was shorter in Asians than in white and black people [10][11][12]. Therefore, the reference ranges of fetal NBL need to be established individually by race and ethnicity [13].…”

Section: Introductionmentioning

confidence: 95%

Normative curves of fetal nasal bone length for the ethnic Chinese population

et al. 2010

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Section: Introductionmentioning

confidence: 95%

Normative curves of fetal nasal bone length for the ethnic Chinese population

et al. 2010

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“…Previous studies investigating the impact of [22] , Afro-American [23] , Chinese [11,12] , Korean [13] , Iranian [14] , Turkish [15,16] , Indian [17] , Japanese [18] , South American [19] , and Australian [20] ( table 2 ). How- ever, ethnicity-related variations in NBL during gestation are likely to have an impact on the efficacy of NBL-based screening for trisomy 21.…”

Section: Discussionmentioning

confidence: 99%

“…Chen et al [11] detected shorter fetal NBs in the Chinese population. Several studies have since shown the impact of race and ethnicity on the nasal bone length (NBL) in second-trimester fetuses: Chinese [11,12] , Korean [13] , Iranian [14] , Turkish [15,16] , Indian [17] , Japanese [18] , Brazilian [19] , and Australian [20] . However, no data have been published about the reference range of NBL of normal fetuses in a large AfroCaribbean population.…”

Section: Introductionmentioning

confidence: 99%

Normal Range of Fetal Nasal Bone Length during the Second Trimester in an Afro-Caribbean Population and Likelihood Ratio for Trisomy 21 of Absent or Hypoplastic Nasal Bone

Gautier

Gueneret²,

Plavonil³

et al. 2016

Fetal Diagn Ther

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Objective: To establish the normal reference range of fetal nasal bone length (NBL) during the second trimester in an Afro-Caribbean population and the likelihood ratio (LR) for fetal trisomy 21. Methods: Prenatal records of euploid, non-malformed singleton fetuses who underwent second-trimester ultrasonographic scans at 20-24 weeks of gestation were retrospectively analyzed for NBL and gestational age (GA). Only Afro-Caribbean couples were selected. The relationship between fetal NBL and GA was determined. The data of all fetuses with Down syndrome were provided by the French West Indies Register of Congenital Malformations (REMALAN). Results: There was a significant linear association between fetal NBL and GA (R² = 0. 354). The 50th percentile for NBL increased from 5.0 to 7.0 mm from week 20 to 24 of gestation. The nasal bone (NB) was absent or hypoplastic in 8.6% of the euploid fetuses and in 69.2% of the trisomy 21 fetuses. The LR for trisomy 21 of absent or hypoplastic NB in an Afro-Caribbean population was 8.02, but only 2.32 when this sign was isolated. Conclusion: The reference range for fetal NBL at 20-24 weeks of gestation in an Afro-Caribbean population and the LR for trisomy 21 of absent or hypoplastic NB differed from the other populations.

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“…3,4 Langdon Down has described trisomy 21 first in 1866 and observed that such individuals have some characteristic features such as flat face and small nose. [5][6][7][8] Recognizing these general characteristics involved in trisomy 13 has helped to clinicians to diagnose the disease during prenatal period through radiological techniques.…”

Section: Introductionmentioning

confidence: 99%

“…In other words, it should be reminded that different ethnic groups may have different reference ranges. 4,6 Therefore, many researchers have revealed reference ranges of face parameters on different ethnic groups. 3,5,11,12 The purpose of our study is to obtain data of some face parameters in Turkish fetal population and to contribute creation of reference ranges that may be used for prenatal diagnosis.…”

Section: Introductionmentioning

confidence: 99%

An assessment of nasal and orbital parameters in human fetuses

et al. 2017

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Background: Nasal bone aplasia and hypoplasia have been reported on fetuses with aneuploidy. Trisomy 21 is one of the most common chromosomal abnormality detected in new-borns. The purpose of our study is to obtain data of some face parameters in Turkish fetal population and to contribute creation of reference ranges that may be used for prenatal diagnosis.Methods: This study was performed in 66 spontaneously aborted fetuses (47 second trimester and 19 third trimester) (28 male and 38 female) with no detectable external pathology or anomalies. Measurements were designed as nasal bone length (NBL), nose length (NL), nose width (NW), nostril width (NsW), intraocular distance (IOD), innercanthal distance (ICD), outercanthal distance (OCD), orbital diameter (OD), biparietal diameter (BPD).Results: In comparison between genders, ICD and BPD averages were found significantly higher in male fetuses than female fetuses (P<0.05). There was not any statistically significant difference between averages of the values on the right and left. The difference between second and the third trimester was significant in terms of all parameters (P<0.05). A strong correlation was detected between gestational age and our parameters.Conclusions: Present study has contributed to create reference ranges of Turkish community. When importance of early diagnosis is considered, we believe that this data will be useful for clinicians.

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Ultrasonographic measurement of fetal nasal bone length in the second trimester in Korean population

Cited by 27 publications

References 16 publications

Normative curves of fetal nasal bone length for the ethnic Chinese population

Normative curves of fetal nasal bone length for the ethnic Chinese population

Normal Range of Fetal Nasal Bone Length during the Second Trimester in an Afro-Caribbean Population and Likelihood Ratio for Trisomy 21 of Absent or Hypoplastic Nasal Bone

An assessment of nasal and orbital parameters in human fetuses

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