Ultrasonographic Findings of Uterine Carcinosarcoma

Zhao, Fangui; Xu, Yang; Zhang, Hao; Ren, Yanling

doi:10.1159/000481885

Cited by 6 publications

(3 citation statements)

References 19 publications

(25 reference statements)

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“…The removal of duplicates and title screening processes yielded 510 and 74 studies, respectively. After abstract screening, 14 studies were evaluated for eligibility [7,8,14,15,16,17,18,19,20,21,22,23,24,25]. Of them, 8 studies were excluded because they did not report the presence of sonographic signs in women with sarcoma [14,15,16,17].…”

Section: Study Selectionmentioning

confidence: 99%

“…After abstract screening, 14 studies were evaluated for eligibility [7,8,14,15,16,17,18,19,20,21,22,23,24,25]. Of them, 8 studies were excluded because they did not report the presence of sonographic signs in women with sarcoma [14,15,16,17]. Finally, 6 studies with 317 sarcoma patients were included in the qualitative and quantitative analyses [7,8,18,19,20,21] (Supplementary Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

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Prevalence of sonographic signs in women with uterine sarcoma: a systematic review and meta-analysis

et al. 2023

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Objective:To assess the prevalence of sonographic signs in uterine sarcomas women. Materials and Methods:A systematic review and meta-analysis was performed searching 5 electronic databases from inception to June 2022 for all studies that allowed to calculate the prevalence of sonographic signs in uterine sarcomas women. Pooled prevalence with 95% confidence intervals was calculated for each sonographic sign and was a priori defined as “very high” when it was ≥ 80%, “high” when it ranged from 80% to 70%, and less relevant when it was ≤ 70%. Results:6 studies with 317 sarcoma patients were included. Pooled prevalence was: 25.0%(95%CI:15.4-37.9%) for absence of visibility of the myometrium; 80.5%(95%CI:74.8-85.2%) for solid component; 78.3%(95%CI:59.3-89.9%) for inhomogeneous echogenicity of solid component; 47.9%(95%CI:41.1-54.8%) for cystic areas; 80.7%(95%CI:68.3-89.0%) for irregular walls of cystic areas; 72.3%(95%CI:16.7-97.2%) for anechoic cystic areas; 54.8%(95%CI:34.0-74.1%) for absence of shadowing; 73.5%(95%CI:43.3-90.9%) for absence of calcifications; 48.7%(95%CI:18.6-79.8%) for color score 3 or 4; 47.3%(95%CI:37.0-57.8%) for irregular tumor borders; 45.4%(95%CI:27.6-64.3%) for endometrial cavity not visualizable; 10.9%(95%CI:3.5-29.1%) for free pelvic fluid; 6.4%(95%CI:1.1-30.2%) for ascites; 21.2%(95%CI:2.1-76.8%) for intracavitary process; 81.5%(95%CI:56.1-93.8%) for singular lesion. Conclusions:Solid component, irregular walls of cystic areas and singular lesions are signs at very high prevalence, while inhomogeneous echogenicity of solid component, anechoic cystic areas and absence of calcifications are signs at high prevalence. Remaining signs were less relevant.

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Section: Study Selectionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Prevalence of sonographic signs in women with uterine sarcoma: a systematic review and meta-analysis

et al. 2023

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“…Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, although it only accounts for approximately 1% of all uterine malignancies. Preoperative diagnosis is very difficult in uterine sarcoma [1], and therefore most patients were diagnosed after surgery. Although many patients are diagnosed at the early stage, the recurrence rate even among patients with uterine-confined disease (FIGO stage I) exceeds 50%, and the 5-year survival rate is approximately 40% [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Reoperation with Total Hysterectomy after Incomplete Surgery Is Helpful in Patients with Incidentally Diagnosed Uterine Leiomyosarcoma

Zhang

Han²,

et al. 2021

Gynecol Obstet Invest

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Objective: The aim of this study was to evaluate the impact of initial surgical treatments and surgical re-exploration on the oncological outcomes of patients with incidentally diagnosed uterine leiomyosarcoma (uLMS). Design: A retrospective analysis of 87 patients who underwent re-exploration for incidentally diagnosed uLMS at the Fudan University Shanghai Cancer Center was performed. Methods: Kaplan-Meier and Cox proportional hazards regression models were used for analyses. Results: The median age (range) at diagnosis was 49 (23–76) years. The median disease-free survival (DFS) and overall survival (OS) were 15.1 and 56.7 months, respectively. The Kaplan-Meier curves and log-rank tests showed the median DFS was longer in patients with restaging operation (N = 30) than without (N = 55) (p = 0.017) but no significant difference in median OS (p = 0.142). In patients who underwent myomectomy/subtotal hysterectomy, 5 patients (28.5%) had remnant sarcoma during re-exploration with complete uterine removal, and re-exploration was associated with longer DFS (p = 0.038) and OS (p = 0.042). Limitations: The limitation of this study is its retrospective observational design with a limited number of patients. Conclusion: Reoperation with total hysterectomy after incomplete surgery may be helpful in patients with incidentally diagnosed uLMS at the first treatment.

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