Ultrasonographic Findings of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis

Ohmori, Nariko; Miyakawa, Megumi; Ohmori, Kazue; Takano, Kazue

doi:10.2169/internalmedicine.46.1901

Cited by 54 publications

(45 citation statements)

References 15 publications

(7 reference statements)

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“…Asymptomatic DTD, especially HT, is known to be significantly related to the occurrence of thyroid malignancy compared with normal thyroid. 9,10 Ohmori et al 11 reported that PTC with HT has a prevalence of 5.5%, which is higher than that of PTC without HT. Therefore, we suggest that the high incidence of asymptomatic DTD reflects thyroid malignancy in 310 patients (91.2%, 310/340) as the main cause of thyroid surgery.…”

Section: Discussionmentioning

confidence: 99%

Sonographic Differentiation of Asymptomatic Diffuse Thyroid Disease from Normal Thyroid: A Prospective Study

Kim¹,

Eun²,

In³

et al. 2010

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Sonographic Differentiation of Asymptomatic Diffuse Thyroid Disease from Normal Thyroid: A Prospective Study

Kim¹,

Eun²,

In³

et al. 2010

AJNR Am J Neuroradiol

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“…Gender The incidence of HT in PTCs according to gender was compared in 23 studies (3,4,5,6,7,14,15,19,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38). HT in PTCs was observed in 1677 of 7346 (23%) female patients and in 180 of 573 (11%) male patients.…”

Section: Clinicopathologic Characteristics Of Ptcs With Htmentioning

confidence: 99%

“…In addition, the clinicopathologic characteristics of PTCs with concomitant HT have not been definitely proposed (3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40). Therefore, the present meta-analysis was conducted to clarify the relationship between PTCs and histologically proven conventional HT and to investigate the clinicopathologic features of PTCs with coexistent HT.…”

Section: Introductionmentioning

confidence: 97%

The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

Lee

Kim

Choi

et al. 2013

European Journal of Endocrinology

258

259

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Objective: No consensus exists on the association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT). To resolve this controversy, this study aimed to evaluate the relationship between the two conditions using a meta-analysis. Methods: We searched relevant published studies using citation databases including PubMed, Embase, and ISI Web of Science. The effect sizes of clinicopathologic parameters were calculated by odds ratio (OR), weighted mean difference, or hazard ratio (HR). The effect sizes were combined using a randomeffects model. Results: Thirty-eight eligible studies including 10 648 PTC cases were selected. Histologically proven HT was identified in 2471 (23.2%) PTCs. HT was more frequently observed in PTCs than in benign thyroid diseases and other carcinomas (ORZ2.8 and 2.4; P!0.001). PTCs with coexisting HT were significantly related to female patients (ORZ2.7; P!0.001), multifocal involvement (ORZ1.5; PZ0.010), no extrathyroidal extension (ORZ1.3; PZ0.002), and no lymph node metastasis (ORZ1.3; PZ0.041). Moreover, PTCs with HT were significantly associated with long recurrence-free survival (HRZ0.6; PZ0.001). Conclusions: Our meta-analysis showed that PTC is significantly associated with pathologically confirmed HT. PTC patients with HT have favorable clinicopathologic characteristics compared with PTCs without HT. However, patients with HT need to be carefully monitored for the development of PTC.

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“…The ultrasonography findings were, however, not diagnostic and it was therefore considered by the authors that it is important to make a careful examination if thyroid carcinoma is suspected in patients with HT because HT presents a variable picture on ultrasonography. 48 Therefore the conclusion is still rather uncertain in that the diagnosis of thyroid cancer in patients with HT is subject to many pitfalls and errors, despite advances in technology. The clinicians must use a spectrum of criteria and careful follow-up of the patients for the final diagnosis.…”

Section: Does Radiation Induce Thyroid Autoimmunity?mentioning

confidence: 99%

Autoimmunity in differentiated thyroid cancer: Significance and related clinical problems

Feldt‐Rasmussen¹,

Rasmussen²

2010

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coexistence of differentiated thyroid cancer (Dtc) and thyroid autoimmune diseases could represent a mere coincidence due to the frequent occurrence of autoimmunity, but there may also be a pathological and causative link between the two conditions. the coincidence of Dtc with Hashimoto's disease has been variably reported at between 0.5 and 22.5 % and of Dtc with Graves' disease between 0 and 9.8 %. In this review available evidence for thyroid autoimmunity in Dtc is summarized and it is concluded that thyroid cancer does coexist with thyroid autoimmunity, implying that patients treated for autoimmune thyroid diseases should have a careful follow-up. Furthermore, the presence of thyroglobulin antibodies (tgAb) in patients with Dtc may limit the use of serum thyroglobulin as a tumor marker due to methodological problems in the determination of serum thyroglobulin. However, in such cases serial tgAb measurements may be used as a surrogate marker for recurrence of thyroid cancer during the long-term monitoring of Dtc patients.

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Ultrasonographic Findings of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis

Abstract: Objective Papillary thyroid carcinoma (PTC) sometimes occurs with Hashimoto's thyroiditis (HT).

Cited by 54 publications

References 15 publications

Sonographic Differentiation of Asymptomatic Diffuse Thyroid Disease from Normal Thyroid: A Prospective Study

Sonographic Differentiation of Asymptomatic Diffuse Thyroid Disease from Normal Thyroid: A Prospective Study

The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

Autoimmunity in differentiated thyroid cancer: Significance and related clinical problems

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