Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction in the diagnosis of biliary dyskinesia in children

Çay, Ali; İmamoğlu, Mustafa; Sarıhan, Haluk; Ahmetoğlu, Ali

doi:10.1080/08035250500459733

Cited by 18 publications

(24 citation statements)

References 13 publications

(23 reference statements)

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“…Nonavailability[ 2 ] of CCK warrants use of a physiological stimulus and fatty meal is used as an alternative. A variety of fatty meals such as lactose-free fatty meal,[ 2 ] a corned beef, and cheese sandwich with milk,[ 3 ] dried egg yolk,[ 4 ] lipomul,[ 5 ] corn oil emulsion,[ 6 ] chocolate,[ 7 ] yoghurt, and chocolate,[ 8 ] Humana,[ 9 ] whipped cream,[ 10 ] half and half milk,[ 11 12 ] and whole milk[ 13 14 ] have been tried. Fatty meal, however, has been institution-specific usually and probably lacked standardization.…”

Section: Discussionmentioning

confidence: 99%

Standardization of "In-House fatty meal" methodology for cholescintigraphy

et al. 2015

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Aim:This study was aimed at standardizing the “In-House fatty meal” methodology in cholescintigraphy and to determine gall bladder ejection fraction (GBEF) with this standardized meal.Materials and Methods:This is a prospective case–control study where 61 patients having right upper quadrant pain and postprandial bloating and 59 healthy volunteers were included. They underwent 99mTc-mebrofenin fatty meal cholescintigraphy following a standard protocol. Dynamic acquisitions over 120 min were done, with a fatty meal being given between 45- and 60-min. Gallbladder emptying kinetics was studied by assessing the time activity curves and calculation of GBEFs were made at 30-min, 45-min, and at 60-min and assessed.Results:The GBEF at 30-min was 74.42% ± 8.26% (mean ± standard deviation), at 45-min was 82.61% ± 6.5%, and at 60-min was 89.37% ± 4.48% in the volunteer group. The lower limit of GBEF in volunteers at 30-min was 58%, 45-min was 69%, and at 60-min was 81%. Receiver operating characteristic (ROC) analysis showed that 30-min GBEF provided the best separation between healthy and diseased subjects with an area under curve of 0.952 (95% confidence interval = 0.914–0.989). The lower limit of GBEF at 30-min was 58%.Conclusions:An in-House standard fatty meal could be a reproducible alternative to cholecystokinin as it is well-tolerated. Based on ROC curve analysis, we propose that 30-min GBEF provides good separation between healthy and diseased people with this in-House fatty meal. Hence, dynamic acquisitions beyond 30-min postingestion of the fatty meal may not be warranted.

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Section: Discussionmentioning

confidence: 99%

Standardization of "In-House fatty meal" methodology for cholescintigraphy

et al. 2015

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“…Recent studies show that cholescintigraphy and ultrasonography are equally effective for the evaluation of gallbladder volume and function (29). We and others have found preprandial and postprandial ultrasound to be useful and reproducible when used with a standard fatty meal (29–32).…”

Section: Discussionmentioning

confidence: 99%

Gallbladder Dysfunction in Cholesterol Ester Storage Disease

Haller

Sharif²,

Millar³

et al. 2010

J. pediatr. gastroenterol. nutr.

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Three of 3 children in our series with CESD had symptomatic gallbladder dysfunction. The diagnosis was established by abdominal ultrasound. Cholecystectomy led to long-lasting relief of biliary symptoms. ConclusionsGallbladder dysfunction appears to be a common cause of chronic abdominal pain in children with CESD. The underlying mechanism of gallbladder disease in this patient cohort is still not well understood.

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“…The gallbladder emptying fraction (GBEF) was assessed by measuring the variation in the gallbladder volume before and after a fatty meal. The gallbladder volume was calculated using the Dodds formula . A reduction in the gallbladder volume of 60% or more was considered satisfactory for its emptying function.…”

Section: Methodsmentioning

confidence: 99%

“…The gallbladder volume was calculated using the Dodds formula. 12 A reduction in the gallbladder volume of 60% or more was considered satisfactory for its emptying function.…”

Section: Postoperative Carementioning

confidence: 99%

A reliable detachable balloon that prevents abdominal cavity contamination during transrectal natural orifice transluminal endoscopic surgery

Fan

Zhao

et al. 2019

J of Digest Diseases

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Objective To evaluate the efficacy and safety of a detachable endoluminal balloon in the prevention of abdominal cavity contamination during transrectal natural orifice transluminal endoscopic surgery (NOTES). Methods The efficacy and safety of a detachable endoluminal balloon to maintain disinfection in the distal colon of the pigs were evaluated. The bacterial loads and colonic cleanliness were monitored. Additionally, the device was applied to another nine pigs that underwent a cholecystotomy by transrectal NOTES. Necropsy and pathological examination were performed after 28‐day follow‐up. Results All animals exposed to the device and one of the seven pigs not exposed to the device scored three points on the bowel cleanliness scale (P < 0.001). After 30 min bacterial loads of the test (with balloon occlusion) and control (without balloon occlusion) groups showed a significant difference (0.8 × 103 CFU/mL vs 186.8 × 103 CFU/mL, P < 0.01). Cholecystotomy by transrectal NOTES with the device was successfully performed. The mean intraperitoneal procedure time was 102.9 ± 37.7 min. There were no procedure‐related adverse events. During the follow‐up, all animals presented normal behavior and appetite. No peritoneal infection or adhesion was detected at autopsy. Cholecystotomy and rectal incision were histologically healed and no histological abnormalities were detected in the colon related to balloon placement. Conclusions The detachable balloon provides a reliable solution for preventing peritoneal contamination during transluminal operations. The technique may assist in future transrectal NOTES.

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Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction in the diagnosis of biliary dyskinesia in children

Cited by 18 publications

References 13 publications

Standardization of "In-House fatty meal" methodology for cholescintigraphy

Standardization of "In-House fatty meal" methodology for cholescintigraphy

Gallbladder Dysfunction in Cholesterol Ester Storage Disease

A reliable detachable balloon that prevents abdominal cavity contamination during transrectal natural orifice transluminal endoscopic surgery

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