Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: A longitudinal study

Lin, Deng‐Yn; Sheen, I‐Shyan; Chiu, Cheng‐Tang; Lin, Shi‐Ming; Kuo, Yow-Chii; Liaw, Yun–Fan

doi:10.1002/jcu.1870210502

Cited by 165 publications

(148 citation statements)

References 18 publications

Supporting

Mentioning

146

Contrasting

Unclassified

Order By: Relevance

“…Forty patients were found to progress to cirrhosis based on the clinical ground and liver ultrasonography [14] until the last visit. Of these, four subsequently developed hepatocellular carcinoma.…”

Section: Resultsmentioning

confidence: 99%

“…From 1980, asymptomatic adults who were incidentally identified as HBsAg carriers during blood donation or health check up were recruited into the present study if they fulfilled the following criteria: (1) HBsAg positive for at least one year; (2) HBeAg negative, anti-HBe positive, normal ALT (0-36 U/l), no evidence of cirrhosis based on the clinical ground and liver ultrasonography [14] and no concomitant infection with hepatitis C virus or hepatitis D virus at baseline; (3) no anti-viral or immunomodulatory therapy before entry and during follow up; (4) regular follow up at least every year and for a minimum of 3 years; (5) available for follow up through 2005. Patients who had alcohol or drugs that might be possible etiological agents of hepatitis were excluded.…”

Section: Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Spontaneous relapse of hepatitis in inactive HBsAg carriers

Chu

Liaw

2007

Hep Intl

Self Cite

View full text Add to dashboard Cite

Background/aims The issue of spontaneous relapse of hepatitis in anti-HBe positive asymptomatic HBsAg carriers was rarely reported before and deserves further exploration. Methods A total of 1241 anti-HBe positive asymptomatic adult HBsAg carriers were prospectively followed up. Of these, 661 (53%) were males, and the mean (±SD) age was 35.6 ± 9.1 years. Relapse of hepatitis was defined as elevation of ALT more than twice the upper limit of normal accompanied by detectable serum HBV DNA by hybridization assays. Results During a mean follow up of 12.3 years, hepatitis relapsed in 211 patients with an annual rate of 1.46%. The cumulative probabilities of hepatitis relapse were 10. 2%, 17.4%, 19.3%, 20.2%, and 20.2%, respectively, after 5, 10, 15, 20, and 25 years of follow up. Multivariate analyses showed that the probability of hepatitis relapse correlated significantly with male sex (P < 0.0001) and age at entry (P = 0.007). The cumulative probability of hepatitis relapse after 20 years was 26.9% for males and only 12.5% for females, and was 13.1% for those of age <30 years at entry but increased to 29.4% for those of age 40-49 years at entry. Conclusion Hepatitis relapsed in about 20% of asymptomatic HBsAg carries during 25 years of follow up. Relapse of hepatitis occurred more frequently during earlier years of follow up. Males were more likely to have relapse of hepatitis than females. In addition, relapse of hepatitis was significantly less frequent in patients who were younger than 30 years at study entry, possibly implicating more favorable outcome of earlier HBeAg seroconversion.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Spontaneous relapse of hepatitis in inactive HBsAg carriers

Chu

Liaw

2007

Hep Intl

Self Cite

View full text Add to dashboard Cite

show abstract

“…Diagnosis of cirrhosis was made histologically in 38 patients and on the basis of repeated ultrasonographic findings suggestive of cirrhotic change and complemented with clinical features such as esophageal varices, thrombocytopenia [14,15] in 55 patients. The diagnosis of HCC was made histologically in 16 patients and based on the image findings together with an AFP level > 400 ng/ml [3] in five patients.…”

Section: Methodsmentioning

confidence: 99%

Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study

et al. 2007

Self Cite

View full text Add to dashboard Cite

Purpose To elucidate the long-term natural course following the onset of cirrhosis in patients with chronic hepatitis B. Methods Ninety-three patients with chronic hepatitis B who had developed cirrhosis during regular follow-up were included in this long-term follow-up study. At the time of cirrhosis detection, 30% of the patients were seropositive for hepatitis B e antigen (HBeAg) and 73% had a HBV-DNA level >10 4 copies/ml. Follow-up studies included liver biochemistry, viral markers, a-fetoprotein and ultrasonography every 3-6 months. Results During a mean follow-up period of 102 ± 60 (12-246; median 97) months, 32 patients (34.4%) experienced 55 episodes of hepatitis flare (7.0%/year), 15 (53.6%) of 28 HBeAg-positive patients seroconverted to anti-HBe (6.3%/yr) and 12 (12.9%) lost HBsAg (1.5%/year). Overall disease progression was observed in 25 (26.9%, 3.2%/year) patients: 12 (12.9%, 1.5%/ year) hepatic decompensation, 21 (22.6%, 2.7%/year) hepatocellular carcinoma and 11 (11.8%, 1.4%/year) died. Multivariate analysis showed that age at onset of cirrhosis (P = 0.015) and persistent HBeAg seropositivity (P = 0.019) were the independent factors for overall disease progression. Conclusions These results suggest that patients with older age at onset of cirrhosis and persistent HBeAg seropositivity following the onset of cirrhosis were independent factors for the disease progression in the first 10-year after the development of cirrhosis in patients with chronic hepatitis B.

show abstract

“…HCC cases were defined based on pathological examination in 54 (25.0%) and by a combination of ultrasound lesions compatible with HCC and an a-fetoprotein (AFP) level >100 ng/ml in 162 (75.0%). Study participants diagnosed with cirrhosis met defined ultrasound criteria for cirrhosis (Lin et al, 1993) and had no focal lesions suggestive of HCC. Controls with no clinical evidence for liver disease (n ¼ 408) were frequency matched by age (within 10 years), gender, and study site.…”

Section: Study Design and Participantsmentioning

confidence: 99%

249ser TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma

Lesi²,

et al. 2005

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) from regions with high dietary exposure to aflatoxins and endemic for hepatitis B virus (HBV) often contain a specific mutation at codon 249 in TP53 (249 ser ; AGG to AGT, Arg to Ser). This mutation is also detectable in circulating cell-free DNA from the plasma of HCC patients and healthy subjects in these regions. We have examined the joint effect of plasma 249 ser and HBV infection in a case-control study design involving 348 control, 98 cirrhotic, and 186 HCC participants from The Gambia, West Africa, an area of high HCC incidence. The 249 ser mutation was detected in 3.5% of controls, 15.3% of cirrhotics, and 39.8% of HCC cases (adjusted odds ratios (OR): 4.83, (95% confidence interval (CI): 1.71-13.7) for cirrhosis and 20.3 (8.19-50.0) for HCC). HBsAg positivity along with plasma 249 ser was observed in 45/183 (24.6%) HCC cases compared to only one (0.3%) control. Risk for HCC was associated with markers of HBV alone (OR: 10.0, 95% CI: 5.16-19.6), 249 ser alone (OR: 13.2, 95% CI: 4.99-35.0), and both markers present (OR: 399, 95% CI: 48.6-3270). These results suggest a multiplicative effect on HCC risk resulting from the mutational effect of aflatoxin on TP53, as monitored by detection of plasma 249 ser , with concomitant chronic infection with HBV.

show abstract

Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: A longitudinal study

Cited by 165 publications

References 18 publications

Spontaneous relapse of hepatitis in inactive HBsAg carriers

Spontaneous relapse of hepatitis in inactive HBsAg carriers

Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study

249ser TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma

Contact Info

Product

Resources

About