Ultrasonographic Assessment of the Prevalence of Hepatic Steatosis in Inactive Hepatitis B Carriers

İnci, Ayşe; Meral, Cenk Emre

doi:10.4274/vhd.53825

Cited by 4 publications

(4 citation statements)

References 5 publications

(4 reference statements)

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“…In the present study, HBsAg-negative patients were in a young age group, and the incidence of NAFLD was significantly higher in older patients in the same group. Previous studies have reported that male gender and advanced age are significant factors in HBV patients (6,7,15,16,17). However, in our study, we could not find a similar correlation with age in patients with positive HBsAg.…”

Section: Discussioncontrasting

confidence: 56%

See 1 more Smart Citation

Can Detection of Non-alcoholic Fatty Liver Disease be Coincidental in Young Patients with Chronic Hepatitis B?

Karacaer¹,

Okur²,

Çermik³

et al. 2016

vhd

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ÖZAmaç: Bu araştırmanın amacı hepatit B yüzey antijeni (HBsAg) pozitif ve negatif genç hastalarda alkolik olmayan yağlı karaciğer hastalığının (AOYKH) sıklığını, AOYKH oluşumu ile ilişkili faktörleri ve hepatit B virüsü (HBV) ile AOYKH'nin birlikte saptanmasının rastlantısal olup olmadığını ortaya koymaktı. Objective: The objective of this study was to determine the factors associated with the presence of non-alcoholic fatty liver disease (NAFLD) in young persons who are hepatitis B surface antigene (HBsAg)-positive and negative, and to investigate if NAFLD coexisting hepatitis B virus (HBV) is coincidental. Materials and Methods:This retrospective study, conducted in a military hospital in Turkey, included a total of 384 subjects. The subjects were divided into two groups according to the presence of NAFLD detected by ultrasonography (US). Sociodemographic characteristics, biochemical, histopathological, virological and US results were recorded . Statistical analysis was performed using SPSS 22.0. Results: The median age of the patients, all of whom were male, was 26 years (20-40). NAFLD was identified in 16.9% of patients. HBsAg positivity was found in 36.9% of patients with NAFLD. It was remarkable that no statistically significant difference was found in HBsAg positivity between the patients with and without NAFLD (p=0.661). NAFLD was found in 13.2% of HBsAg-positive patients. NAFLD was determined in 20.3% of HBsAg-negative patients. No significant difference was found in NAFLD grades between HBsAg-positive and negative patients (p=0.158). In the present study, only γ-glutamyl transferase in HBsAg positive patients, and age, alanine transaminase and aspartate transaminase in HBsAg negative patients were determined as the most important factors associated with the presence of NAFLD. Conclusion:We found that HBsAg positivity is not correlated with the development of NAFLD in young patients, and coexistence of NAFLD and HBV might be coincidental.

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Section: Discussioncontrasting

confidence: 56%

“…The prevalence of NAFLD is 19.8% in our country (13), whereas in Western populations this rate has been reported to be between 20% and 30% (14). According to the Turkish data, NAFLD is found in 21.1-52% of inactive HBsAg carriers (6,15,16), and in 39% of CHB patients (7). In their study performed in Indonesia, Lesmana et al.…”

Section: Discussionmentioning

confidence: 99%

Can Detection of Non-alcoholic Fatty Liver Disease be Coincidental in Young Patients with Chronic Hepatitis B?

Karacaer¹,

Okur²,

Çermik³

et al. 2016

vhd

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“…The prevalence of NAFLD has been rated and graded according to the USG results in many publications [9, 11, 13, 25, 26]. Overall, hepatic USG is a simple, noninvasive technique that is widely used in clinical practice to detect the fatty infiltration of the liver [27].…”

Section: Discussionmentioning

confidence: 99%

The prevalence of non-alcoholic fatty liver disease in healthy young persons

Okur

Karacaer

2016

North Clin Istanbul

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OBJECTIVE:This aim of the present study was to determine prevalence of non-alcoholic fatty liver disease (NAFLD) in healthy young persons admitted for annual medical check-ups.METHODS:A retrospective study was conducted in a military hospital. Total of 254 healthy males were included and participants were divided into 2 groups according to presence and grade of NAFLD. Demographic data, biochemical test results, and ultrasonography findings were collected from all patients. Statistical analyses were performed using SPSS software, version 22.0 (SPSS, Inc., Chicago, IL, USA).RESULTS:Prevalence of NAFLD was 10.6%. Significant differences were found with regard to age; levels aspartate transaminase, alanine transaminase, gamma-glutamyl transferase, and alkaline phosphatase; body mass index (BMI); and presence of NAFLD (p=0.014, p=0.022, p=0.003, p≤0.001, p=0.004, and p≤0.001, respectively). When compared to those with grade 1 NAFLD, levels of alanine transaminase, fasting blood glucose, gamma-glutamyl transferase, triglycerides, total cholesterol and age variables were higher in those with grade 2 NAFLD. However, no statistically significant difference was noted when comparing grades of NAFLD.CONCLUSION:Though this study included patients with normal BMI and normal laboratory test results, presence of NAFLD was not rare in these otherwise healthy young men. Liver enzyme levels were within normal limits; however, there was slight tendency to be high consistent with presence and grade of NAFLD.

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“…Bir çalışmada ultrasonografinin yağlı karaciğerdeki duyarlılığı %90,4, özgüllüğü %97,3, pozitif kestirim değeri %97,3, negatif kestirim değeri %94,8 olarak saptanmıştır (23). Ultrasonografi aynı zamanda inaktif HBV taşıyıcılarının izlenmesinde hepatoselüler karsinom taraması yanında diğer yapısal bulgular yönünden de önem taşımaktadır (24)(25)(26). Hastalarımızda ultrasonografik incelemede 10 hastada karaciğerde basit kist, 15 hastada safra kesesinde taş, 16 hastada safra kesesinde polip, 27 hastada böbrekte basit kist, 7 hastada karaciğerde hemanjiyom, 8 hastada geçirilmiş kolesistektomi ve 6 hastada ise splenomegali saptandı.…”

Section: Gereç Ve Yöntemunclassified

İnaktif Hepatit B Taşıyıcılarında Hepatosteatoz: Sıklığı, Biyokimyasal ve Viral Parametrelerin Değerlendirilmesi

Korkmaz¹,

Aykın²,

Çevik³

et al. 2013

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Ultrasonographic Assessment of the Prevalence of Hepatic Steatosis in Inactive Hepatitis B Carriers

Abstract: Re cei ved/Ge liş ta ri hi: 17.05.2013 Ac cep ted/Ka bul ta ri hi: 05.06.2013 © Viral Hepatit Dergisi, Ga le nos Ya y› ne vi ta ra f›n dan ba s›l m›fl t›r.

Cited by 4 publications

References 5 publications

Can Detection of Non-alcoholic Fatty Liver Disease be Coincidental in Young Patients with Chronic Hepatitis B?

Can Detection of Non-alcoholic Fatty Liver Disease be Coincidental in Young Patients with Chronic Hepatitis B?

The prevalence of non-alcoholic fatty liver disease in healthy young persons

İnaktif Hepatit B Taşıyıcılarında Hepatosteatoz: Sıklığı, Biyokimyasal ve Viral Parametrelerin Değerlendirilmesi

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