Ultrasonographic assessment of skeletal muscle mass and diaphragm function in patients with chronic obstructive pulmonary disease: A case–control study

Ramachandran, Priya; Devaraj, Uma; Patrick, Bhavna; Saxena, Deepti; Venkatnarayan, Kavitha; Louis, Varghese; Krishnaswamy, Uma Maheswari

doi:10.4103/lungindia.lungindia_103_19

Cited by 10 publications

(15 citation statements)

References 27 publications

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“…Dois estudos (Ramachandran et al, 2020;Shrikrishna et al, 2012;) associaram a AST com o volume expirado forçado no primeiro segundo (VEF1), em que não foram encontradas diferenças significativas. Com isso, é possível notar que a AST avaliada pela US não tem relação com a VEF1, porém há estudos que afirmam que a AST possui influência na força nos diferentes níveis de severidade (Barbarov et al, 2019;Seymour et al, 2012;Shrikrishna et al, 2012).…”

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“…A AST encontra-se reduzida em pacientes com DPOC quando comparada à indivíduos saudáveis e até mesmo entre os níveis de GOLD (Ramachandran et al, 2020;Seymour et al, 2012;Ye et al, 2017). Seymour et al (2009), apontaram que a AST estava reduzida em cerca de 25% em pacientes com DPOC comparada a indivíduos saudáveis.…”

Section: Referênciasunclassified

“…Com isso, sugere-se que a AST, avaliada pela US, pode ser utilizada como biomarcador para a presença e gravidade da disfunção musculoesquelética nesses pacientes (Ramachandran et al, 2020;Shrikrishna et al, 2012;Wallbridge et al, 2018;Ye et al, 2017), devido ao seu alto índice de confiabilidade intraclasse 0,98 e interclasse > 0,95 (Menon et al, 2012), bem como entre um avaliador experiente e inexperiente 0,78 (Hammond et al, 2014).…”

Section: Referênciasunclassified

“…Além disso, estudos apontam que a aplicação da técnica da US na musculatura do quadríceps em pacientes com DPOC, apresenta-se como uma técnica confiável, barata, reprodutível, sem risco de exposição à radiação, como outras técnicas de avaliação. Trata-se de um recurso de baixo custo, minimamente invasivo e com poucos riscos, podendo ser utilizada como uma ferramenta útil e pode substituir outras ferramentas de avaliação por ser sensível a mudanças ao longo do tempo, permitindo a avaliação e monitorização da disfunção muscular periférica e que pode ser utilizado como marcador para identificar disfunção muscular clinicamente significativa (Barbarov et al, 2019;Cruz-Montecinos et al, 2016;Hammond et al, 2014;Maynard-Paquette et al, 2020;Menon et al, 2012;Nijholt et al, 2019;Ramachandran et al, 2020;Seymour et al, 2009;Wallbridge et al, 2018;Ye et al, 2017;).…”

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“…Todavia, a literatura ainda não traz pontos de corte para avaliação do uso da US na musculatura do quadríceps, apenas estudos comparativos entre a população com DPOC e indivíduos saudáveis, ou entre os próprios estágios da doença (Ramachandran et al, 2020;Seymour et al, 2012;Ye et al, 2017).…”

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The use of ultrasonography as a tool to evaluate the quadriceps muscle in patients with chronic obstructive pulmonary disease: a systematic review

Santos¹,

Santos²,

Wassmuth³

et al. 2022

RSD

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The aim of this review is to understand the feasibility and potential clinical utility of US in measurements of the quadriceps muscles in patients with COPD. A total of 217 studies were identified and after applying the inclusion criteria, 12 were selected. The data were systematically searched by two independent reviewers. Of the included articles, five evaluated the maximal voluntary contraction of the quadriceps muscle and the Transverse Section Area (TSA) measured by US, of these, 4 found a remarkably reduced strength in COPD and in one article, it was described that this reduction occurs in all grades of the disease. Moreover, the greater the thickness of the quadriceps, the greater the maximum voluntary contraction of this musculature, however, the TSA is reduced in these patients when compared to healthy individuals. Thus, it is suggested that the AST, evaluated by US, can be used to assess the presence and/or severity of musculoskeletal dysfunction in these patients. The sonographic evaluation of the quadriceps in patients with COPD may provide a safe, effective, low-cost, reliable and reproducible evaluation, allowing the identification and monitoring of peripheral muscle dysfunction in this population, even when compared with other strategies.

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Section: Referênciasunclassified

Section: Introductionunclassified

See 3 more Smart Citations

The use of ultrasonography as a tool to evaluate the quadriceps muscle in patients with chronic obstructive pulmonary disease: a systematic review

Santos¹,

Santos²,

Wassmuth³

et al. 2022

RSD

View full text Add to dashboard Cite

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Ultrasonographic evaluation of diaphragm function in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

et al. 2022

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Background: Some studies have reported using ultrasonic evaluations to assess diaphragm function in patients with chronic obstructive pulmonary disease (COPD). However, they have limitations and thus cannot provide strong evidence to support ultrasound evaluations for diaphragm function and dysfunction severity assessments in this patient population. Additionally, quantitative studies on the relationship between ultrasound evaluations and diaphragm function do not exist. Therefore, we performed a systematic review and meta-analysis to explore the usefulness of ultrasonography for evaluating diaphragm function in patients with COPD. Methods: The Cochrane Library, PubMed, Embase, Web of Science, Chinese Biomedical Literature Database, Wanfang Data, China National Knowledge Network, and Chinese Scientific Journal Database (i.e., VIP) databases were searched for literature about ultrasonic evaluations of diaphragm function in patients with COPD for systematic review. We extracted patient demographic, diaphragm mobility, diaphragm thickness, diaphragm thickening score, and other related parameter data using RevMan 5.3 software for the meta-analysis. Results: We included 13 articles in the systematic review, 8 of which (494 participants) were included in the meta-analysis. The degree of diaphragm offset in patients with COPD was significantly lower than that in healthy controls (weighted mean difference [WMD] = –1.34; 95% confidence interval [CI]: –2.15, 0.53; P < .05). The diaphragm deviation was lower in the severe COPD group than in the mild-to-moderate COPD group (WMD = 0.50; 95% CI: –0.01, 1.01; P = .06), but the difference was not significant. Conclusion: Ultrasonography effectively evaluates diaphragm function in patients with COPD. The diaphragm offset can be used as an auxiliary diagnostic index for COPD, which is also related to disease severity.

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Correlation between rectus femoris muscle cross-sectional area and the severity of airflow limitation in COPD patients

Sweed,

Khalil,

Elganady

et al. 2023

Egypt J Bronchol

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Peripheral muscle dysfunction is a well-recognized complication of COPD associated with exercise (in)tolerance and worse prognosis. The evaluation of peripheral muscle integrity is an attractive marker in COPD patients.The aim of the study was to identify the correlation between the rectus femoris muscle cross-sectional area (RFCSA) and the severity of airway obstruction in COPD patients using ultrasound.The study enrolled 24 outpatients diagnosed with stable COPD (post-bronchodilator FEV1/FVC < 0.001*. There was a significant negative correlation between RFCSA and age only in cases with very severe airflow limitation. Among COPD patients, there was a significant negative correlation between average RFCSA and mMRC score (r = − 0.864*, p < 0.001*), but not with FEV1 (r = 0.165, p = 0.442). No significant correlation between average RFCSA and neither CRP nor heart rate in COPD patients (r = − 0.169, p = 0.431, r = − 0.285, p = 0.178, respectively. Among COPD, there was a significant positive correlation between RFCSA and QMVC (r = 0.881*, p < 0.001*). COPD cases showed reduced RFCSA, reduced QMVC, shorter 6MWD distance, and higher mMRC score in comparison to the control group.Ultrasound measurement of RFCSA is an effort-independent, radiation-free method that relates to strength and should be applied as an assessment tool for COPD patients.

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Ultrasonographic assessment of skeletal muscle mass and diaphragm function in patients with chronic obstructive pulmonary disease: A case–control study

Cited by 10 publications

References 27 publications

The use of ultrasonography as a tool to evaluate the quadriceps muscle in patients with chronic obstructive pulmonary disease: a systematic review

The use of ultrasonography as a tool to evaluate the quadriceps muscle in patients with chronic obstructive pulmonary disease: a systematic review

Ultrasonographic evaluation of diaphragm function in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

Correlation between rectus femoris muscle cross-sectional area and the severity of airflow limitation in COPD patients

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