Ultrasonication-assisted synthesis of alcohol-based deep eutectic solvents for extraction of active compounds from ginger

Hsieh, Yun‐Hao; Li, Yuanbin; Pan, Zuchen; Chen, Zhengjian; Lu, Jiahai; Yuan, Jumao; Zhu, Zhenye; Zhang, Jiaheng

doi:10.1016/j.ultsonch.2019.104915

Cited by 87 publications

(74 citation statements)

References 54 publications

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“…As shown in Figure 5, the DNR powder before ultrasonic extraction displayed a rough and coarse surface with many flakes (Figure 5a), whereas the surface of powder after ultrasonic extraction in water, methanol, and ChCl-Mal displayed some breakages along the edges without any flakes (Figure 5b-d). The results illustrated that both the conventional solvents (water and methanol) and NADES (ChCl-Mal) could destroy the cells and cell walls as well as dissolved those weak flakes during ultrasonic extraction [30].…”

Section: Microstructure Of Plant Materialsmentioning

confidence: 98%

Natural Deep Eutectic Solvents for the Extraction of Bioactive Steroidal Saponins from Dioscoreae Nipponicae Rhizoma

et al. 2021

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In the present study, a simple and environmentally friendly extraction method based on natural deep eutectic solvents (NADESs) was established to extract four bioactive steroidal saponins from Dioscoreae Nipponicae Rhizoma (DNR). A total of twenty-one types of choline chloride, betaine, and L-proline based NADESs were tailored, and the NADES composed of 1:1 molar ratio of choline chloride and malonic acid showed the best extraction efficiency for the four steroidal saponins compared with other NADESs. Then, the extraction parameters for extraction of steroidal saponins by selected tailor-made NADES were optimized using response surface methodology and the optimal extraction conditions are extraction time, 23.5 min; liquid–solid ratio, 57.5 mL/g; and water content, 54%. The microstructure of the DNR powder before and after ultrasonic extraction by conventional solvents (water and methanol) and the selected NADES were observed using field emission scanning electron microscope. In addition, the four steroidal saponins were recovered from NADESs by D101 macroporous resin with a satisfactory recovery yield between 67.27% and 79.90%. The present research demonstrates that NADESs are a suitable green media for the extraction of the bioactive steroidal saponins from DNR, and have a great potential as possible alternatives to organic solvents for efficiently extracting bioactive compounds from natural products.

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Section: Microstructure Of Plant Materialsmentioning

confidence: 98%

Natural Deep Eutectic Solvents for the Extraction of Bioactive Steroidal Saponins from Dioscoreae Nipponicae Rhizoma

et al. 2021

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“…For example, using US for extraction of gingerols from ginger powder at 50 °C enhanced the extraction of gingerol yield. However, a degradation of the active compound occurred at higher temperatures [ 76 ]. Boulatov [ 75 ] reported that the mechanochemical effects of the US results in overstretching of macromolecules polymers (like carbohydrate and protein chains) that lead to their fragmentation.…”

Section: Application Of Us In Herbal Sciencementioning

confidence: 99%

Recent innovations of ultrasound green technology in herbal phytochemistry: A review

Gouda

Bekhit

Tang

et al. 2021

Ultrasonics Sonochemistry

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Highlights Ultrasound enhances the phenolic compounds in extracted herbal oils by 44%. US (25–50 kHz) increases the yields of polyphenols, carotenoids, and flavonoids. Radicals generated by US have positive and negative effects on enzymes. US improves the efficiency of herbal extracts in Nanotechnology applications. Acoustic-based biosensors could be used for chemical imaging of herbal tissues.

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“…Hsieh at al. have also used the ultrasonic waves for the synthesis of polyalcohol-based DES [64]. Based on the results confirmed by Hsieh et al, sonification with a frequency of 40 kHz at room temperature (RT) and a sonification time of up to 5 h should be used to produce clear and colorless liquids [64].…”

Section: Short Historical Overview Of Development and Use Of Des/nadesmentioning

confidence: 99%

“…have also used the ultrasonic waves for the synthesis of polyalcohol-based DES [64]. Based on the results confirmed by Hsieh et al, sonification with a frequency of 40 kHz at room temperature (RT) and a sonification time of up to 5 h should be used to produce clear and colorless liquids [64]. Recently, in a short communication by Gomez et al, a faster, simpler, cheaper and more environmentally friendly method of DES synthesis, based on microwave irradiation was described for the first time [65].…”

Section: Short Historical Overview Of Development and Use Of Des/nadesmentioning

confidence: 99%

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

120

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The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.

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Ultrasonication-assisted synthesis of alcohol-based deep eutectic solvents for extraction of active compounds from ginger

Cited by 87 publications

References 54 publications

Natural Deep Eutectic Solvents for the Extraction of Bioactive Steroidal Saponins from Dioscoreae Nipponicae Rhizoma

Natural Deep Eutectic Solvents for the Extraction of Bioactive Steroidal Saponins from Dioscoreae Nipponicae Rhizoma

Recent innovations of ultrasound green technology in herbal phytochemistry: A review

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

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