Abstract:A green method was developed for the synthesis of 12 α-hydroxyphosphonates 3a-l through the Pudovik reaction of diethyl phosphite (2) and aromatic/heterocyclic aldehydes 1a-l under sonication and conventional conditions using ZnO nano sheets as a catalyst. The advantages of this protocol are high yields, high purity of the desired products, short reaction times, easy workup, and reusability of the catalyst. The structure of the catalyst, ZnO nano sheets, was elucidated by EDS, TEM, XRD, and IR and the title co… Show more
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